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BioActivity Data for Compound Oxypurinol (CID 4644)

BioActivity Outcomes:
Inactive(532)
 
 
Inconclusive(7)
 
 
Unspecified(6)
 
 
Top Targets:
7tm 4(35)
 
 
NR LBD PPAR(8)
 
 
NR LBD ER(7)
 
 
NR LBD AR(7)
 
 
NR LBD VDR(5)
 
 
BioAssay Types:
Screening(313)
 
 
 
Confirmatory(182)
 
 
 
 
Summary(29)
 
 
 
Literature(16)
 
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(106)
 
 
 
Toxicity(11)
 
 
 
ADME(4)
 
 
Cell-based(94)
 
 
Organism-base..(8)
 
 
BioActivity Types:
Potency(193)
 
 
 
 
IC50(11)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 505    Data Row: 545   Total Pages: 28   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103224360]
Kd 794.328Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysis [AID491531, Type: Literature]Purine nucleoside phosphorylase [gi:614115254]
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2
[SID103224360]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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3
[SID103224360]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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4
[SID103224360]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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5
[SID103224360]
Binding energy by using the equation deltaG obsd = -RT ln KD [AID227718, Type: Literature]
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6
[SID57264357]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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7
[SID57264357]
Potency 0.1qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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8
[SID144211537]
Potency-Replicate_1 0.4897qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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9
[SID57264357]
Potency 1.5849A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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10
[SID144211537]
Potency-Replicate_1 68.5896qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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11
[SID144211537]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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12
[SID144211537]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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13
[SID144211537]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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14
[SID144211537]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cell free culture [AID720686, Type: confirmatory]
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15
[SID144211537]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cells [AID720687, Type: confirmatory]
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16
[SID144211537]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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17
[SID144211537]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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18
[SID144211537]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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19
[SID144211537]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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20
[SID57264357]
Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition [AID720647, Type: screening]
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