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BioActivity Data for Compound Oxprenolol (CID 4631)

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BioActivity Outcomes:
Active(4)
 
 
Inactive(18)
 
 
Inconclusive(16)
 
 
Unspecified(79)
 
 
Top Targets:
MFS(3)
 
 
 
Bcl-2 like(1)
 
 
CAP ED(1)
 
 
DUF3371(1)
 
 
HLH(1)
 
 
BioAssay Types:
Literature(97)
 
 
 
 
 
Screening(16)
 
 
 
Confirmatory(2)
 
 
BioActivity Types:
IC50(18)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 117    Data Row: 117   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176474]
IC50 28.6Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy [AID386625, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
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2
[SID85220236]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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3
[SID85788907]
Luminescence Cell-Based Primary HTS to Measure Viability of BJeLR cells [AID2275, Type: screening]
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4
[SID103176474]
Unbound drug concentration in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604020, Type: Literature]
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5
[SID103176474]
Unbound volume of distribution in Sprague-Dawley rat brain measured per gram of brain tissue administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604021, Type: Literature]
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6
[SID103176474]
Fraction unbound in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604022, Type: Literature]
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7
[SID103176474]
Ratio of total drug level in brain to plasma in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604023, Type: Literature]
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8
[SID103176474]
Unbound brain to plasma concentration ratio in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr [AID604024, Type: Literature]
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9
[SID103176474]
Unbound CSF to plasma concentration ratio in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604025, Type: Literature]
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10
[SID103176474]
Permeability across human Caco-2 cells [AID455986, Type: Literature]
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11
[SID103176474]
Human intestinal absorption in po dosed human [AID476929, Type: Literature]
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12
[SID103176474]
Dissociation constant, pKa of the compound [AID350216, Type: Literature]
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13
[SID103176474]
Octanol-water partition coefficient, log Pn of the compound [AID350217, Type: Literature]
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14
[SID103176474]
Octanol-water partition coefficient, log PC of the compound [AID350218, Type: Literature]
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15
[SID103176474]
Lipophilicity, log K at pH 2 by by hydrophilic interaction chromatography using 95% acetonitrile as mobile phase [AID350219, Type: Literature]
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16
[SID103176474]
Lipophilicity, log K at pH 2 by by hydrophilic interaction chromatography using 100% water as mobile phase [AID350220, Type: Literature]
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17
[SID103176474]
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy [AID386623, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
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18
[SID103176474]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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19
[SID103176474]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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20
[SID103176474]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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