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BioActivity Data for Compound Oxprenolol (CID 4631)

BioActivity Outcomes:
Active(4)
 
 
Inactive(18)
 
 
Inconclusive(16)
 
 
Unspecified(101)
 
 
Top Targets:
MFS(3)
 
 
 
Bcl-2 like(1)
 
 
CAP ED(1)
 
 
DUF3371(1)
 
 
HLH(1)
 
 
BioAssay Types:
Literature(117)
 
 
 
 
 
Screening(16)
 
 
 
Confirmatory(2)
 
 
BioAssay Categories:
In vitro(1)
 
 
In vivo(4)
 
 
Biochemical(16)
 
 
 
 
Toxicity(19)
 
 
ADME(46)
 
 
 
Cell-based(14)
 
 
 
 
BioActivity Types:
IC50(18)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 139    Data Row: 139   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176474]
IC50 28.6Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy [AID386625, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
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2
[SID85788907]
Luminescence Cell-Based Primary HTS to Measure Viability of BJeLR cells [AID2275, Type: screening]
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3
[SID103176474]
Unbound drug concentration in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604020, Type: Literature]
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4
[SID85220236]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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5
[SID103176474]
Percent of the drug absorbed after administration to humans was determined [AID15120, Type: Literature]
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6
[SID103176474]
Percent of drug absorbed by human intestine after oral administration [AID18847, Type: Literature]
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7
[SID103176474]
Cellular permeability (Pc) (Caco-2 cell monolayer) [AID28399, Type: Literature]
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8
[SID103176474]
Ionization constant (pKa) [AID29359, Type: Literature]
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9
[SID103176474]
Oral bioavailability in human [AID29812, Type: Literature]
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10
[SID103176474]
Fraction absorbed after oral administration in humans [AID29844, Type: Literature]
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11
[SID103176474]
Estimation of fraction absorbed (Fa) in the human intestine using biosensor technology. [AID29845, Type: Literature]
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12
[SID103176474]
Binding constant against human serum albumin (HSA) [AID91481, Type: Literature]
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13
[SID103176474]
Binding to POPC (palmitoyl-oleolyl-phosphatidyl-choline) liposomes using biosensor system [AID156202, Type: Literature]
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14
[SID103176474]
Binding to POPC/GMI liposomes using biosensor system [AID156204, Type: Literature]
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15
[SID103176474]
Ratio of [(apical to basal)/(basal to apical)] (Caco-2 cell monolayer) [AID231333, Type: Literature]
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16
[SID103176474]
In vivo beta-adrenoceptor blocking potency in cat (expressed as total dose infused over a period of 30 minutes causing 50% inhibition of the tachycardia by iv administration) [AID48524, Type: Literature]
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17
[SID103176474]
Permeability coefficient through artificial membrane in presence of unstirred water layer by PAMPA [AID288184, Type: Literature]
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18
[SID103176474]
Permeability coefficient through artificial membrane in presence of stirred water layer [AID288185, Type: Literature]
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19
[SID103176474]
Partition coefficient, log P of the compound [AID288192, Type: Literature]
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20
[SID103176474]
Distribution coefficient measured in Octanol/buffer (0.15 M KCl) [AID26525, Type: Literature]
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