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BioActivity Data for Compound Oxprenolol (CID 4631)

BioActivity Outcomes:
Active(4)
 
 
Inactive(18)
 
 
Inconclusive(16)
 
 
Unspecified(101)
 
 
Top Targets:
MFS(3)
 
 
 
Bcl-2 like(1)
 
 
CAP ED(1)
 
 
DUF3371(1)
 
 
HLH(1)
 
 
BioAssay Types:
Literature(117)
 
 
 
 
 
Screening(16)
 
 
 
Confirmatory(2)
 
 
BioAssay Categories:
In vivo(4)
 
 
Biochemical(13)
 
 
 
Toxicity(19)
 
 
ADME(45)
 
 
 
Cell-based(11)
 
 
 
 
BioActivity Types:
IC50(18)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 139    Data Row: 139   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176474]
IC50 28.6Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy [AID386625, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
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2
[SID103176474]
Unbound drug concentration in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604020, Type: Literature]
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3
[SID85220236]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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4
[SID85788907]
Luminescence Cell-Based Primary HTS to Measure Viability of BJeLR cells [AID2275, Type: screening]
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5
[SID103176474]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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6
[SID103176474]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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7
[SID103176474]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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8
[SID103176474]
Apparent permeability across human Caco2 cell membrane after 2 hrs by LC-MS/MS analysis [AID592681, Type: Literature]
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9
[SID103176474]
In-vivo blood/plasma to lung partition coefficients of the compound, logP(lung) in rat [AID603954, Type: Literature]
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10
[SID103176474]
Unbound volume of distribution in Sprague-Dawley rat brain measured per gram of brain tissue administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604021, Type: Literature]
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11
[SID103176474]
Fraction unbound in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604022, Type: Literature]
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12
[SID103176474]
Ratio of total drug level in brain to plasma in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604023, Type: Literature]
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13
[SID103176474]
Unbound brain to plasma concentration ratio in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr [AID604024, Type: Literature]
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14
[SID103176474]
Unbound CSF to plasma concentration ratio in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604025, Type: Literature]
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15
[SID103176474]
TP_TRANSPORTER: inhibition of cimetidine uptake (Cimetidine: 100 uM, Oxprenolol: 1000 uM) in OCT2-expressing mIMCD3 cells [AID681962, Type: Literature]Solute carrier family 22 member 2 [gi:313104182]
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16
[SID103176474]
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy [AID386623, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
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17
[SID103176474]
Hydrophobicity, log P of the compound in octanol-water by shaking-flask method [AID1091958, Type: Literature]
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18
[SID103176474]
Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 [AID1159387, Type: other]
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19
[SID103176474]
Estimation of fraction absorbed (Fa) in the human intestine using biosensor technology. [AID29845, Type: Literature]
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20
[SID103176474]
Fraction absorbed after oral administration in humans [AID29844, Type: Literature]
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