Bookmark and Share
Oxprenolol (CID 4631) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(4)
 
 
Inactive(18)
 
 
Inconclusive(16)
 
 
Unspecified(55)
 
 
Top Targets:
MFS(3)
 
 
 
NAD binding 8(1)
 
 
Myc N(1)
 
 
Bcl-2 like(1)
 
 
MSH6 like(1)
 
 
BioAssay Types:
Literature(70)
 
 
 
 
 
Screening(16)
 
 
 
Confirmatory(2)
 
 
BioActivity Types:
IC50(18)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 93    Data Row: 93   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176474]
IC50 28.6Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy [AID386625, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
View
2
[SID85220236]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
View
3
[SID85788907]
Luminescence Cell-Based Primary HTS to Measure Viability of BJeLR cells [AID2275, Type: screening]
View
4
[SID103176474]
Unbound drug concentration in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604020, Type: Literature]
View
5
[SID103176474]
Unbound volume of distribution in Sprague-Dawley rat brain measured per gram of brain tissue administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604021, Type: Literature]
View
6
[SID103176474]
Fraction unbound in Sprague-Dawley rat plasma administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604022, Type: Literature]
View
7
[SID103176474]
Ratio of total drug level in brain to plasma in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604023, Type: Literature]
View
8
[SID103176474]
Unbound brain to plasma concentration ratio in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr [AID604024, Type: Literature]
View
9
[SID103176474]
Unbound CSF to plasma concentration ratio in Sprague-Dawley rat administered in casettes of 2/3 drugs at 4 hr constant rate intravenous infusions using flow rate of 1 (ml/kg)/hr corresponding to dosage rate of 2 (umol/kg)/hr by LC-MS/MS method [AID604025, Type: Literature]
View
10
[SID103176474]
Permeability across human Caco-2 cells [AID455986, Type: Literature]
View
11
[SID103176474]
Human intestinal absorption in po dosed human [AID476929, Type: Literature]
View
12
[SID103176474]
Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement [AID4411, Type: Literature]
View
13
[SID103176474]
Percent of the drug absorbed after administration to humans was determined [AID15120, Type: Literature]
View
14
[SID103176474]
Percent of drug absorbed by human intestine after oral administration [AID18847, Type: Literature]
View
15
[SID103176474]
Mono layer permeability of human intestinal Caco-2 cells [AID21254, Type: Literature]
View
16
[SID103176474]
Partition coefficient (logP) [AID23471, Type: Literature]
View
17
[SID103176474]
pK value is evaluated [AID25049, Type: Literature]
View
18
[SID103176474]
Dissociation constant of the compound [AID25572, Type: Literature]
View
19
[SID103176474]
Distribution coefficient measured in Octanol/buffer (0.15 M KCl) [AID26525, Type: Literature]
View
20
[SID103176474]
Delta logD (logD6.5 - logD7.4) [AID27167, Type: Literature]
View
21
[SID103176474]
Apparent permeability coefficient (Papp) (Caco-2 cell monolayer) [AID28392, Type: Literature]
View
22
[SID103176474]
Cellular permeability (Pc) (Caco-2 cell monolayer) [AID28399, Type: Literature]
View
23
[SID103176474]
Partition coefficient (logD6.5) [AID28681, Type: other]
View
24
[SID103176474]
Ionization constant (pKa) [AID29359, Type: other]
View
25
[SID103176474]
Oral bioavailability in human [AID29812, Type: Literature]
View
26
[SID103176474]
Fraction absorbed after oral administration in humans [AID29844, Type: Literature]
View
27
[SID103176474]
Estimation of fraction absorbed (Fa) in the human intestine using biosensor technology. [AID29845, Type: Literature]
View
28
[SID103176474]
Beta-blocking activity was measured by applying the stepwise linear discriminate analysis; Active [AID41895, Type: other]
View
29
[SID103176474]
Beta adrenoceptor blocking potency was estimated by inhibition of 50% of the tachycardia produced by a submaximal dose of the isoproterenol (0.2ug/kg, intravenously) [AID41903, Type: Literature]
View
30
[SID103176474]
Beta-1-adrenoreceptor antagonsim of compound expressed as inhibition of isoprenaline-induced tachycardia in the ganglion-blocked anesthetized cat [AID48346, Type: Literature]
View
31
[SID103176474]
Intrinsic Sympathomimetic Activity (ISA) determined from the ratio of the maximal compound and isoprenaline induced tachycardia in anesthetized ganglion blocked cats following intravenous administration [AID48368, Type: Literature]
View
32
[SID103176474]
In vivo beta-adrenoreceptor blocking potency in cat (expressed as total dose infused over a period of 30 minutes causing 50% inhibition of the tachycardia by iv administration) [AID48524, Type: Literature]
View
33
[SID103176474]
Beta-adrenoreceptor blocking potency in cat, measured as the degree (percent) of blockade of the vasodepressor response at the dose level [AID48526, Type: Literature]
View
34
[SID103176474]
Percent inhibition of vasorepressor response [AID48537, Type: Literature]
View
35
[SID103176474]
Beta-adrenoreceptor blocking potency in the isolated guinea pig heart, giving 50% inhibition of isoproterenol-induced tachycardia [AID78651, Type: Literature]
View
36
[SID103176474]
Beta-adrenoreceptor blocking potency in the isolated guinea pig heart, giving 50% inhibition of isoproterenol-induced tachycardia relative to oxprenolol [AID78664, Type: Literature]
View
37
[SID103176474]
Binding constant against human serum albumin (HSA) [AID91481, Type: Literature]
View
38
[SID103176474]
Binding to POPC (palmitoyl-oleolyl-phosphatidyl-choline) liposomes using biosensor system [AID156202, Type: Literature]
View
39
[SID103176474]
Binding to POPC/GMI liposomes using biosensor system [AID156204, Type: Literature]
View
40
[SID103176474]
Ratio of [(apical to basal)/(basal to apical)] (Caco-2 cell monolayer) [AID231333, Type: Literature]
View
41
[SID103176474]
Tested for fraction of oral dose absorbed orally in humans [AID237585, Type: Literature]
View
42
[SID103176474]
Permeability coefficient through artificial membrane in presence of unstirred water layer by PAMPA [AID288184, Type: Literature]
View
43
[SID103176474]
Permeability coefficient through artificial membrane in presence of stirred water layer [AID288185, Type: Literature]
View
44
[SID103176474]
Partition coefficient, log P of the compound [AID288192, Type: Literature]
View
45
[SID103176474]
Permeability coefficient in human skin [AID311367, Type: Literature]
View
46
[SID103176474]
Partition coefficient, log P of the compound [AID312895, Type: Literature]
View
47
[SID103176474]
Partition coefficient, log P by UPLC method [AID312896, Type: Literature]
View
48
[SID103176474]
Dissociation constant, pKa of the compound [AID350216, Type: Literature]
View
49
[SID103176474]
Octanol-water partition coefficient, log Pn of the compound [AID350217, Type: Literature]
View
50
[SID103176474]
Octanol-water partition coefficient, log PC of the compound [AID350218, Type: Literature]
View