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oxiracetam (CID 4626) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(299)
 
 
Inconclusive(7)
 
 
Unspecified(25)
 
 
Top Targets:
NR LBD ER(8)
 
 
NR LBD AR(7)
 
 
Pyr redox dim(5)
 
 
7TM GPCR Srx(5)
 
 
NR LBD TR(5)
 
 
BioAssay Types:
Confirmatory(208)
 
 
 
 
 
Literature(91)
 
 
 
Summary(16)
 
 
 
Screening(13)
 
 
BioActivity Types:
Potency(219)
 
 
 
 
 
EC50(2)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 249    Data Row: 334   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50106803]
Potency 2.8184qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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2
[SID103213022]
EC50 5.96NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: other]
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3
[SID103213022]
EC50 6.22NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: other]
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4
[SID103213022]
CC50 57.48NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) [AID449705, Type: other]
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5
[SID103213022]
NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. [AID449706, Type: other]
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6
[SID103213022]
Amnesia-reversal activity in ECS-induced amnesia model of mice at 1 mg/kg i.p. [AID125741, Type: Literature]
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7
[SID103213022]
Amnesia-reversal activity in ECS-induced amnesia model of mice at 10 mg/kg i.p. [AID125742, Type: Literature]
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8
[SID103213022]
Amnesia-reversal activity (AA) evaluated in ECS-induced amnesia model of mice at a dose of 100 mg/kg [AID125743, Type: Literature]
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9
[SID103213022]
Amnesia-reversal activity in scopolamine-induced amnesia model of mice at 1 mg/kg i.p. [AID125744, Type: Literature]
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10
[SID103213022]
Percent reversal of scopolamine-induced amnesia rat following 1.0 mg/kg i.p. [AID191743, Type: Literature]
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11
[SID103213022]
Percent reversal of scopolamine-induced amnesia rat following 10 mg/kg i.p. [AID191745, Type: Literature]
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12
[SID103213022]
Percent reversal of scopolamine-induced amnesia rat at 10 mg/kg po [AID191746, Type: Literature]
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13
[SID103213022]
Percent reversal of scopolamine-induced amnesia rat at 30 mg/kg po [AID191747, Type: Literature]
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14
[SID103213022]
Total clearance in human [AID444051, Type: Literature]
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15
[SID103213022]
Hepatic clearance in human [AID444052, Type: Literature]
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16
[SID103213022]
Renal clearance in human [AID444053, Type: Literature]
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17
[SID103213022]
Oral bioavailability in human [AID444054, Type: Literature]
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18
[SID103213022]
Fraction absorbed in human [AID444055, Type: Literature]
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19
[SID103213022]
Fraction escaping gut-wall elimination in human [AID444056, Type: Literature]
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20
[SID103213022]
Fraction escaping hepatic elimination in human [AID444057, Type: Literature]
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21
[SID103213022]
Volume of distribution at steady state in human [AID444058, Type: Literature]
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22
[SID50106803]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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23
[SID103213022]
Volume of distribution at steady state in human after iv administration [AID540209, Type: Literature]
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24
[SID103213022]
Clearance in human after iv administration [AID540210, Type: Literature]
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25
[SID103213022]
Mean residence time in human after iv administration [AID540212, Type: Literature]
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26
[SID103213022]
Half life in human after iv administration [AID540213, Type: Literature]
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27
[SID50106803]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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28
[SID85231168]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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29
[SID50106803]
Potency 0.0224qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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30
[SID85231168]
Potency 0.8913qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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31
[SID144203769]
Potency-Replicate_1 2.1132qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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32
[SID90341150]
Potency 4.7755qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay [AID720538, Type: confirmatory]arylsulfatase A [Homo sapiens] [gi:220983390]
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33
[SID85231168]
Potency 37.6858qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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34
[SID90341150]
Potency 44.6684qHTS of Trypanosoma Brucei Inhibitors: LOPAC Validation [AID624147, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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35
[SID85231168]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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36
[SID90341150]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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37
[SID50106803]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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38
[SID17405491]
HTS for BAP1 Enzyme inhibitors [AID436, Type: screening]Ubiquitin carboxyl-terminal hydrolase BAP1 [gi:68565074]
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39
[SID85231168]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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40
[SID90341150]
Potency qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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41
[SID85231168]
Potency qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase: hit validation [AID492961, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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42
[SID50106803]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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43
[SID50106803]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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44
[SID85231168]
Potency qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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45
[SID85231168]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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46
[SID50106803]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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47
[SID90341150]
Potency High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity: MmCpn Primary Screen [AID488978, Type: confirmatory]chaperonin GroEL [Methanococcus maripaludis S2] [gi:45359078]
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48
[SID50106803]
Potency qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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49
[SID50106803]
Potency qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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50
[SID90341150]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: HTRF assay [AID743207, Type: confirmatory]glucokinase regulatory protein [Homo sapiens] [gi:221625433]
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