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STK397048 (CID 460749) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(182)
 
 
Inactive(409)
 
 
Inconclusive(54)
 
 
Unspecified(2)
 
 
Top Targets:
alkPPc(14)
 
 
Bcl-2 like(13)
 
 
 
7TM GPCR Srx(12)
 
 
 
 
7TM GPCR Srsx(11)
 
 
 
Tryp SPc(6)
 
 
BioAssay Types:
Screening(394)
 
 
 
 
 
Confirmatory(232)
 
 
 
 
 
Literature(8)
 
 
 
BioActivity Types:
Potency(137)
 
 
 
 
 
IC50(57)
 
 
 
 
EC50(24)
 
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 607    Data Row: 647   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14723875]
EC50_uM 0.0305Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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2
[SID14723875]
IC50 0.039SMAD Transcription Factor Inhibitors Dose Response Confirmation [AID715, Type: confirmatory]mothers against decapentaplegic homolog 3 isoform 1 [Homo sapiens] [gi:5174513]
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3
[SID14723875]
AC50_uM 0.0409Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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4
[SID14723875]
AC50_uM 0.0579Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]Probable replicative DNA helicase DnaB [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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5
[SID14723875]
IC50 0.11102Luminescence-based counterscreen for inhibitors of the SARS coronavirus 3C-like Protease (3CLPro): dose response biochemical high throughput screening assay to identify inhibitors of the papain-like protease (PLpro) [AID1944, Type: confirmatory]
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6
[SID85736034]
Potency 0.1296qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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7
[SID14723875]
Potency 0.259qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Initial hit validation in AlphaScreen assay for MBNL1-(CUG)12 binding [AID493205, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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8
[SID14723875]
EC50_uM 0.3648Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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9
[SID14723875]
IC50 0.396Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) [AID1692, Type: confirmatory]Sphingosine-1-phosphate receptor 4 [Homo sapiens] [gi:15929025]
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10
[SID14723875]
AC50_uM 0.4409Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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11
[SID14723875]
AC50_uM 0.5085ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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12
[SID14723875]
IC50 0.634Counterscreen for S1P2 Antagonists: Dose Response Cell-Based Screen to Identify Antagonists of CRE-BLA [AID856, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
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13
[SID14723875]
Potency 0.6506qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding: Initial hit validation from the primary screen [AID493199, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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14
[SID14723875]
DR EC50 uM 0.89NIH Compound Library Profiling: Compound and DTT Dependent Redox Cycling H2O2 Generation 10-point Concentration Response Confirmation Assay. [AID1234, Type: confirmatory]
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15
[SID85736034]
Potency 0.8913Confirmation qHTS Assay for Inhibitors of Cruzain [AID2158, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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16
[SID14723875]
Potency 0.9285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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17
[SID14723875]
IC50 0.996Dose Response Cell Based Assay for Antagonists of the S1P2 Receptor [AID851, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
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18
[SID14723875]
Potency 1qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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19
[SID85736034]
Potency 1qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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20
[SID14723875]
Potency 1.0582Confirmatory Assay for Inhibitors of Human Galactokinase (GALK): Phenol-HRP redox assay counterscreen [AID2035, Type: confirmatory]
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21
[SID85736034]
Potency 1.0691qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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22
[SID14723875]
Potency 1.122qHTS Assay for Inhibitors of Human Galactokinase (GALK) [AID1868, Type: confirmatory]galactokinase [Homo sapiens] [gi:4503895]
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23
[SID14723875]
Potency 1.1873Confirmation Assay for Inhibitors of Human Galactokinase (GALK) [AID2015, Type: confirmatory]galactokinase [Homo sapiens] [gi:4503895]
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24
[SID85736034]
Potency 1.1917qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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25
[SID85736034]
Potency 1.2589qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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26
[SID164141672]
IC50 1.28Inhibition of Yersinia pestis YopH catalytic domain (residues 163-468) using pNPP substrate [AID724959, Type: Literature]
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27
[SID85736034]
Potency 1.4125qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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28
[SID85736034]
Potency 1.5849qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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29
[SID14723875]
Potency 1.5849qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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30
[SID14723875]
Potency 1.5849qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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31
[SID14723875]
Potency 1.5849qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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32
[SID85736034]
Potency 1.9953qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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33
[SID85736034]
Potency 1.9953qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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34
[SID14723875]
IC50 2.343Fluorescence-based counterscreen assay for S1P4 antagonists: Cell-based dose response high throughput screening assay to identify antagonists of the Sphingosine 1-Phosphate Receptor 1 (S1P1) [AID1821, Type: confirmatory]sphingosine 1-phosphate receptor 1 [Homo sapiens] [gi:13027636]
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35
[SID14723875]
EC50 4.068Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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36
[SID14723875]
IC50 4.427Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3): TR-FRET-based biochemical high throughput dose response assay to identify agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) [AID2759, Type: confirmatory]nuclear receptor corepressor 2 isoform 2 [Homo sapiens] [gi:116256445]
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37
[SID14723875]
IC50 4.427Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3): TR-FRET-based biochemical high throughput dose response assay to identify agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) [AID2759, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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38
[SID14723875]
Potency 4.4668qHTS Assay for Agonists of the Relaxin Receptor RXFP1 [AID2676, Type: confirmatory]relaxin receptor 1 isoform 1 [Homo sapiens] [gi:85986601]
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39
[SID14723875]
Potency 5.6234qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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40
[SID14723875]
Absolute IC50 7.16Dose Response Confirmation for Small Molecule Inhibitors of Epstein-Barr Virus [AID1419, Type: confirmatory]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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41
[SID14723875]
IC50 7.34573Image-Based HTS for Selective Antagonists for GPR55 [AID2013, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
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42
[SID85736034]
Potency 8.1995Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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43
[SID14723875]
Potency 8.9125qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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44
[SID14723875]
Potency 14.0685Secondary Assay for Inhibitors of Human Galactokinase (GALK): HEK-293 Cell Viability Assay [AID2547, Type: confirmatory]
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45
[SID14723875]
EC50 16.768Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex-5 [gi:55976631]
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46
[SID14723875]
EC50 17.644Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA [AID1964, Type: confirmatory]Protein POS-1 [Caenorhabditis elegans] [gi:17562800]
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47
[SID85736034]
Potency 17.7828qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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48
[SID14723875]
IC90 20Intein inhibitors as potential Tuberculosis drugs [AID489010, Type: confirmatory]RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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49
[SID14723875]
EC50_uM 24.02Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]glycogen synthase kinase-3 beta isoform 1 [Homo sapiens] [gi:21361340]
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50
[SID14723875]
Potency 31.6228qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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