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Guaiacol (CID 460) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(1351)
 
 
Inconclusive(70)
 
 
Unspecified(30)
 
 
Top Targets:
NR LBD PPAR(41)
 
 
 
NR LBD AR(34)
 
 
 
NR LBD ER(34)
 
 
 
NR LBD TR(24)
 
 
NR LBD GR(22)
 
 
 
 
BioAssay Types:
Confirmatory(870)
 
 
 
 
 
Screening(368)
 
 
Literature(96)
 
 
 
 
Summary(87)
 
 
 
BioActivity Types:
Potency(792)
 
 
 
 
 
IC50(29)
 
 
 
EC50(4)
 
 
Ki(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 754    Data Row: 1457   Total Pages: 30   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176224]
Ki 2.94Inhibition of human erythrocyte CA2 esterase activity using 4-nitrophenyl acetate substrate [AID416126, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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2
[SID144213965]
Potency-Replicate_1 4.3541qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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3
[SID144213965]
Potency-Replicate_1 24.4757qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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4
[SID144213965]
Potency-Replicate_1 24.6884qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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5
[SID144213965]
Potency-Replicate_1 69.0083qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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6
[SID48416072]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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7
[SID103176224]
Ki 60.2Inhibition of human erythrocyte CA1 esterase activity using 4-nitrophenyl acetate substrate [AID416125, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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8
[SID103176224]
IC50 6310Inhibitory activity on germination of Bacillus subtilis PCI219 spores was determined. [AID40623, Type: Literature]
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9
[SID103176224]
Inhibition of Bacillus subtilis PCI219 spore germination, expressed as log 1/I50 [AID40936, Type: Literature]
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10
[SID103176224]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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11
[SID103176224]
Activity against caspase-mediated apoptosis in mouse L1210 cells at 0.1 mM [AID282833, Type: Literature]
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12
[SID103176224]
Activity against caspase-mediated apoptosis in mouse L1210 cells [AID282834, Type: Literature]
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13
[SID103176224]
Antiinflammatory activity in CD1 mouse assessed as inhibition of croton oil-induced ear oedema at 0.3 umol/cm^2 after 6 hrs [AID309363, Type: Literature]
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14
[SID103176224]
Partition coefficient (logP) [AID23251, Type: Literature]
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15
[SID103176224]
Partition coefficient (logP) (benzene) [AID23252, Type: Literature]
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16
[SID103176224]
Partition coefficient (logP) (carbon tetrachloride) [AID23253, Type: Literature]
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17
[SID103176224]
Partition coefficient (logP) (chloroform) [AID23254, Type: Literature]
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18
[SID103176224]
Partition coefficient (logP) (ether) [AID23255, Type: Literature]
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19
[SID103176224]
Partition coefficient (logP) (hexane) [AID23256, Type: Literature]
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20
[SID103176224]
Dissociation constant (pKa) [AID25611, Type: Literature]
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21
[SID103176224]
Partition coefficient (logD7.2) [AID26261, Type: Literature]
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22
[SID103176224]
Partition coefficient (logP) [AID26793, Type: Literature]
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23
[SID17388828]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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24
[SID103176224]
Inhibition of human recombinant MMP1 at 1 mM after 30 mins [AID566702, Type: Literature]Interstitial collagenase [gi:116852]
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25
[SID103176224]
Inhibition of human recombinant MMP2 at 1 mM after 30 mins [AID566703, Type: Literature]72 kDa type IV collagenase [gi:116856]
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26
[SID103176224]
Inhibition of human recombinant MMP3 at 1 mM after 30 mins [AID566704, Type: Literature]Stromelysin-1 [gi:116857]
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27
[SID103176224]
Inhibition of human recombinant MMP8 at 1 mM after 30 mins [AID566705, Type: Literature]Neutrophil collagenase [gi:116862]
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28
[SID103176224]
Inhibition of human recombinant 5-lipoxygenase at 1 mM after 10 mins by fluorescence assay [AID566700, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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29
[SID103176224]
Inhibition of mouse recombinant iNOS at 1 mM after 40 mins by colorimetric assay [AID566707, Type: Literature]Nitric oxide synthase, inducible [gi:266649]
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30
[SID17389539]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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31
[SID17388828]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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32
[SID17389094]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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33
[SID103176224]
Inhibition of human recombinant MMP9 at 1 mM after 30 mins [AID566706, Type: Literature]Matrix metalloproteinase-9 [gi:269849668]
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34
[SID103176224]
Inhibition of mushroom tyrosinase at 1 mM after 10 mins [AID566699, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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35
[SID49825822]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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36
[SID103176224]
Inhibition of recombinant anthrax lethal factor at 1 mM after 30 mins by fluorescence assay [AID566701, Type: Literature]Lethal factor [gi:50402185]
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37
[SID49825822]
Potency 0.0037Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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38
[SID144213965]
Potency-Replicate_1 0.0983qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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39
[SID144213965]
Potency-Replicate_1 1.2272qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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40
[SID144213965]
Potency-Replicate_1 2.2004qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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41
[SID17388828]
Potency 5.0119qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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42
[SID49825822]
Potency 14.7157Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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43
[SID144213965]
Potency-Replicate_1 27.4727qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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44
[SID144213965]
Potency-Replicate_1 54.8153qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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45
[SID144213965]
Potency-Replicate_1 69.0083qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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46
[SID144213965]
Potency-Replicate_1 69.0083qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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47
[SID144213965]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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48
[SID144210188]
Potency-Replicate_1 qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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49
[SID144210188]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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50
[SID144210188]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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