Ofloxacin (CID 4583) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(151)
 
 
Inactive(784)
 
 
Inconclusive(74)
 
 
Unspecified(1109)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
7TM GPCR Srsx(18)
 
 
 
p450(18)
 
 
 
 
HELICc(11)
 
 
STKc ERK1 2 l..(8)
 
 
 
BioAssay Types:
Literature(1115)
 
 
 
 
 
Confirmatory(387)
 
 
 
 
 
Screening(382)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(346)
 
 
 
 
 
IC50(163)
 
 
 
 
 
EC50(7)
 
 
 
 
AC50(6)
 
 
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1941    Data Row: 2118   Total Pages: 43   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56423109]
IC50 0.23A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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2
[SID56423109]
IC50 0.31A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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3
[SID56423109]
IC50 0.39A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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4
[SID103163813]
MIC 0.4Minimum inhibitory concentration required in vitro against Shigella [AID203039, Type: Literature]
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5
[SID103163813]
MIC 0.4Minimum inhibitory concentration required in vitro against Salmonella [AID200345, Type: Literature]
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6
[SID103163813]
MIC 0.43Antimicrobial activity against Escherichia coli by broth microdilution method [AID385163, Type: Literature]
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7
[SID103163813]
MIC 0.43Antimicrobial activity against Staphylococcus aureus by broth microdilution method [AID385168, Type: Literature]
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8
[SID103163813]
MIC 0.43Antimicrobial activity against Pseudomonas aeruginosa by broth microdilution method [AID385165, Type: Literature]
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9
[SID56423109]
IC50 0.56A screen for inhibitors of the PhoP regulon in Salmonella Typhimurium using a modified counterscreen. [AID1981, Type: confirmatory]
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10
[SID103163813]
MIC 0.7Antimicrobial activity against nonreplicating persistence Mycobacterium tuberculosis H37Rv in aerobic condition assessed as bacterial density after 7 days [AID285160, Type: Literature]
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11
[SID103163813]
MIC 0.78Minimum inhibitory concentration against Escherichia coli ATCC 25922 [AID69479, Type: Literature]
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12
[SID56423109]
IC50 0.8A Counter Screen to identiry small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID2401, Type: confirmatory]
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13
[SID103163813]
MIC 0.8Minimum inhibitory concentration required in vitro against Staphylococcus aureus [AID206009, Type: Literature]
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14
[SID103163813]
MIC 0.86Antimicrobial activity against Enterococcus faecalis by broth microdilution method [AID385166, Type: Literature]
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15
[SID103163813]
MIC 0.86Antimicrobial activity against Bacillus cereus by broth microdilution method [AID385167, Type: Literature]
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16
[SID103163813]
MIC 1.5Minimum inhibitory concentration required in vitro against Streptococcus D [AID208737, Type: Literature]
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17
[SID103163813]
IC50 1.5Inhibition of Escherichia coli DNA gyrase GyrA/GyrB [AID530379, Type: Literature]
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18
[SID103163813]
IC50 1.73Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -limited broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562242, Type: Literature]
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19
[SID103163813]
IC50 1.73Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -limited broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562245, Type: Literature]
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20
[SID56423109]
IC50 1.73A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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21
[SID11533038]
AC50 1.95Ste24 Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-03_Inhibitor_Dose_CherryPick_Activity [AID488815, Type: confirmatory]STE24 [Saccharomyces cerevisiae] [gi:1015837]
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22
[SID103163813]
IC50 2.03Antimycobacterial activity against Mycobacterium smegmatis grown in Luria-Bertani broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562243, Type: Literature]
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23
[SID103163813]
IC50 2.03Antimycobacterial activity against Mycobacterium smegmatis grown in Luria-Bertani broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562240, Type: Literature]
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24
[SID103163813]
MIC 2.13Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by agar dilution method [AID442657, Type: Literature]
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25
[SID103163813]
MIC 2.3Antimicrobial activity against nonreplicating persistence Mycobacterium tuberculosis H37Rv in aerobic condition assessed by relative light units after 7 days [AID285159, Type: Literature]
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26
[SID103163813]
IC50 3Inhibition of Mycobacterium tuberculosis DNA gyrase GyrB/GyrA M74I and A83S mutant [AID530373, Type: Literature]
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27
[SID11533038]
EC50 3.033Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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28
[SID103163813]
IC50 3.13Antimycobacterial activity against Mycobacterium smegmatis grown in carbon-limited broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562241, Type: Literature]
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29
[SID103163813]
IC50 3.13Antimycobacterial activity against Mycobacterium smegmatis grown in carbon-limited broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562244, Type: Literature]
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30
[SID11533038]
EC50 3.694Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
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31
[SID103163813]
IC50 4Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA A83S mutant/GyrB R447K mutant gene [AID530377, Type: Literature]
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32
[SID11533038]
EC50 4.106Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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33
[SID103163813]
IC50 7Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA/GyrB R447K mutant gene [AID530375, Type: Literature]
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34
[SID103163813]
IC50 7Inhibition of Mycobacterium tuberculosis DNA gyrase GyrB/GyrA A83S mutant [AID530369, Type: Literature]
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35
[SID103163813]
IC50 7Inhibition of Mycobacterium tuberculosis DNA gyrase GyrB/GyrA A83S, S84A, I85V, F96W and P101M mutant [AID530371, Type: Literature]
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36
[SID103163813]
IC50 8Inhibition of Mycobacterium tuberculosis DNA gyrase GyrB/GyrA A83S, S84A and I85V mutant [AID530370, Type: Literature]
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37
[SID11533038]
AC50 9.264Trypsin Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-02_Inhibitor_Dose_CherryPick_Activity [AID488789, Type: confirmatory]Trypsin [gi:136429]
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38
[SID26747609]
Potency 10qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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39
[SID103163813]
IC50 11Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA M74I and A83S mutant/GyrB R447K mutant gene [AID530378, Type: Literature]
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40
[SID103163813]
IC50 11Inhibition of [3H]muscimol binding to GABA A receptor 4-biphenylacetic acid at 10 e-4 M [AID71980, Type: Literature]
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41
[SID103163813]
Kd 12Binding affinity to first site on human serum albumin by SPR [AID557095, Type: Literature]Serum albumin [gi:113576]
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42
[SID103163813]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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43
[SID103163813]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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44
[SID124880996]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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45
[SID124880996]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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46
[SID124880996]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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47
[SID50106760]
Potency 14.1254qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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48
[SID103163813]
IC50 20Inhibition of Mycobacterium tuberculosis DNA gyrase GyrA/GyrB N464S mutant gene [AID530376, Type: Literature]
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49
[SID124880996]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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50
[SID124880996]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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