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NSC630254 (CID 457676) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Unspecified(10)
 
 
Top Targets:
GH31 MGAM SI..(4)
 
 
Glyco hydro 3..(1)
 
 
AmyAc Glg deb..(1)
 
 
BioAssay Types:
Literature(16)
 
 
 
BioActivity Types:
IC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 16    Data Row: 16   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103624144]
IC50 0.38Inhibition of rat intestinal brush border membrane maltase [AID342793, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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2
[SID103624144]
IC50 0.6Inhibition of rat intestinal brush border membrane isomaltase [AID342795, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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3
[SID103624144]
IC50 2.6Inhibition of rat intestinal brush border membrane sucrase [AID342797, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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4
[SID103624144]
IC50 4.22Inhibition of rat intestinal alpha-glucosidase using sucrose as substrate assessed as glucose formation incubated for 10 mins prior to substrate addition measured after 30 mins by glucose oxidase method [AID778972, Type: Literature]
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5
[SID103624144]
IC50 6.1Inhibition of rabbit muscle amylo-1,6-glucosidase [AID342805, Type: Literature]Glycogen debranching enzyme [gi:544379]
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6
[SID103624144]
IC50 18Inhibition of human lysosomal alpha-glucosidase [AID342799, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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7
[SID103624144]
Inhibition of human lysosomal beta-glucosidase at 1000 uM [AID342802, Type: Literature]Glucosylceramidase [gi:55584151]
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8
[SID103624144]
Inhibition of rabbit glycogen phosphorylase B at 400 uM [AID342804, Type: Literature]
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9
[SID103624144]
Hypoglycemic effect in starch-challenged ICR mouse assessed as glucose AUC at 10 mg/kg, po by glucose oxidase method (Rvb = 430.1 +/- 44.7 mg.hr/dL) [AID778964, Type: Literature]
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10
[SID103624144]
Hypoglycemic effect in starch-challenged ICR mouse assessed as blood glucose level at 10 mg/kg, po after 120 mins by glucose oxidase method (Rvb = 174.2 +/- 22.9 mg/dL) [AID778965, Type: Literature]
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11
[SID103624144]
Hypoglycemic effect in starch-challenged ICR mouse assessed as blood glucose level at 10 mg/kg, po after 60 mins by glucose oxidase method (Rvb = 243.0 +/- 29.0 mg/dL) [AID778966, Type: Literature]
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12
[SID103624144]
Hypoglycemic effect in starch-challenged ICR mouse assessed as blood glucose level at 10 mg/kg, po after 30 mins by glucose oxidase method (Rvb = 278.9 +/- 33.5 mg/dL) [AID778967, Type: Literature]
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13
[SID103624144]
Hypoglycemic effect in sucrose-challenged ICR mouse assessed as glucose AUC at 10 mg/kg, po by glucose oxidase method (Rvb = 323.2 +/- 37.2 mg.hr/dL) [AID778968, Type: Literature]
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14
[SID103624144]
Hypoglycemic effect in sucrose-challenged ICR mouse assessed as blood glucose level at 10 mg/kg, po after 120 mins by glucose oxidase method (Rvb = 137.8 +/- 14.5 mg/dL) [AID778969, Type: Literature]
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15
[SID103624144]
Hypoglycemic effect in sucrose-challenged ICR mouse assessed as blood glucose level at 10 mg/kg, po after 60 mins by glucose oxidase method (Rvb = 183.3 +/- 29.1 mg/dL) [AID778970, Type: Literature]
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16
[SID103624144]
Hypoglycemic effect in sucrose-challenged ICR mouse assessed as blood glucose level at 10 mg/kg, po after 30 mins by glucose oxidase method (Rvb = 187.4 +/- 21.6 mg/dL) [AID778971, Type: Literature]
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