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Dactinomycin (CID 457193) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(417)
 
 
Inactive(218)
 
 
Inconclusive(237)
 
 
Unspecified(365)
 
 
Top Targets:
NR LBD PPAR(26)
 
 
 
 
NR LBD ER(20)
 
 
 
 
 
p450(20)
 
 
 
 
 
NR LBD AR(19)
 
 
 
 
 
7TM GPCR Srsx(17)
 
 
 
BioAssay Types:
Literature(442)
 
 
 
 
 
Confirmatory(391)
 
 
 
 
Summary(48)
 
 
 
 
Screening(17)
 
 
 
BioActivity Types:
Potency(379)
 
 
 
 
IC50(220)
 
 
 
 
 
EC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 833    Data Row: 1237   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103579573]
IC50 8e-05Antitumor activity against CD4+ human acute T-lymphoblastic C8166 leukemia cells. [AID42389, Type: Literature]
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2
[SID103579573]
IC50 0.0002Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay [AID355583, Type: Literature]
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3
[SID103579573]
IC50 0.0004Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay [AID405551, Type: Literature]
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4
[SID144209680]
Potency-Replicate_1 0.0007qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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5
[SID103579573]
IC50 0.0008Cytotoxicity against human A2780 cells [AID403798, Type: Literature]
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6
[SID103579573]
IC50 0.0008Cytotoxicity against human A2780 cells [AID377761, Type: Literature]
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7
[SID103579573]
IC50 0.0008Antiproliferative activity against human C8166 cell line by MTT assay [AID269028, Type: Literature]
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8
[SID103579573]
IC50 0.0008Antitumor activity against CD+ human acute T-lymphoblastic leukemia C8166 cells [AID42388, Type: Literature]
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9
[SID103579573]
IC50 0.0009Antitumor activity against CD4+ human acute T-lymphoblastic MT-4 leukemia cells. [AID104318, Type: Literature]
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10
[SID103579573]
IC50 0.0009Antiproliferative activity against human MT4 cell line by MTT assay [AID269029, Type: Literature]
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11
[SID144209680]
Potency-Replicate_1 0.0009qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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12
[SID103579573]
IC50 0.001Antiproliferative activity against human CCRF-CEM cell line by MTT assay [AID269031, Type: Literature]
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13
[SID103579573]
IC50 0.001Antiproliferative activity against human G361 cell line by MTT assay [AID269032, Type: Literature]
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14
[SID103579573]
IC50 0.001Antiproliferative activity against human KB cell line by MTT assay [AID269038, Type: Literature]
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15
[SID103579573]
IC50 0.001Antiproliferative activity against human MOLT4 cell line by MTT assay [AID269026, Type: Literature]
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16
[SID103579573]
IC50 0.001Cytotoxicity against human HeLa cells in log-phase after 48 hrs by MTT assay [AID399050, Type: Literature]
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17
[SID103579573]
IC50 0.001Cytotoxicity against african green monkey Vero cells in log-phase after 48 hrs by MTT assay [AID399054, Type: Literature]
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18
[SID103579573]
IC50 0.001Antitumor activity against human CD4+T cells expressing the TAT gene of HTLV-1 MT-4 cells [AID104437, Type: Literature]
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19
[SID103579573]
IC50 0.001Antitumor activity against human acute T-lymphoblastic MOLT-4 leukemia cells. [AID105506, Type: Literature]
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20
[SID103579573]
IC50 0.001Antitumor activity against human acute T-lymphoblastic leukemia MOLT-4 cells [AID105507, Type: Literature]
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21
[SID103579573]
ID50 0.001In vitro cytotoxicity against L1210 cell line as concentration required for 50% inhibition of cell growth [AID96801, Type: Literature]
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22
[SID103579573]
ID50 0.001In vitro concentration required for growth inhibition of murine L1210 tumor cell [AID98677, Type: Literature]
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23
[SID103579573]
IC50 0.001Antitumor activity against CD+ human acute T-lymphoblastic leukemia MT-4 cells [AID104317, Type: Literature]
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24
[SID103579573]
IC50 0.001Antitumor activity against human acute T-lymphoblastic leukemia CCRF-CEM cells [AID44012, Type: Literature]
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25
[SID103579573]
IC50 0.001Antitumor activity against human skin melanoma G-361 cells [AID72413, Type: Literature]
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26
[SID103579573]
IC50 0.001Antitumor activity against human skin melanoma G361 cells. [AID72414, Type: Literature]
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27
[SID103579573]
IC50 0.001Antitumor activity against human acute B-lymphoblastic CCRF-SB leukemia cells. [AID44371, Type: Literature]
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28
[SID144209680]
Potency-Replicate_1 0.0011qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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29
[SID103579573]
IC50 0.0011Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay [AID670602, Type: Literature]
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30
[SID103579573]
GI50 0.0012Cytotoxicity against human Hep G2 cells [AID378059, Type: Literature]
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31
[SID103579573]
GI50 0.0016Cytotoxicity against human HM02 cells [AID378058, Type: Literature]
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32
[SID103579573]
IC50 0.0016Cytotoxicity against human CCRF-CEM cells after 72 hrs [AID382900, Type: Literature]
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33
[SID144209680]
Potency-Replicate_1 0.0017qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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34
[SID103579573]
GI50 0.0019Cytotoxicity against human Hep G2 cells [AID378060, Type: Literature]
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35
[SID103579573]
IC50 0.002Antiproliferative activity against human CCRF-SB cell line by MTT assay [AID269030, Type: Literature]
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36
[SID103579573]
IC50 0.002Antitumor activity against human acute B-lymphoblastic leukemia CCRF-SB cells [AID44372, Type: Literature]
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37
[SID103579573]
CC50 0.002Cytotoxicity for Peripheral blood Lymphocytes [AID154807, Type: Literature]
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38
[SID103579573]
IC50 0.002Antitumor activity against human Burkitt lymphoma Raji cells. [AID165907, Type: Literature]
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39
[SID103579573]
IC50 0.002Antitumor activity against human Burkitt lym phoma Raji cells [AID166398, Type: Literature]
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40
[SID103579573]
IC50 0.002Antitumor activity against human skin melanoma SKMEK-28 cells [AID202826, Type: Literature]
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41
[SID144209680]
Ratio Potency (uM) 0.00227757qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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42
[SID144205550]
Potency-Replicate_1 0.0024qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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43
[SID26755270]
Potency 0.0024Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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44
[SID17390061]
Potency 0.0025Cell Viability - LYMP2-021 [AID974, Type: confirmatory]
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45
[SID144209680]
Potency-Replicate_1 0.0027qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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46
[SID103579573]
IC50 0.0029Antiproliferative activity against human HT29 cells after 48 hrs by MTT assay [AID405550, Type: Literature]
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47
[SID103579573]
IC50 0.003Antiproliferative activity against human 5637 cell line by MTT assay [AID269037, Type: Literature]
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48
[SID103579573]
IC50 0.003Antiproliferative activity against human Wil2-NS cells by MTT assay [AID269027, Type: Literature]
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49
[SID103579573]
IC50 0.003Antitumor activity against human splenic B-lymphoblastoid Wil-NS cells. [AID219231, Type: Literature]
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50
[SID103579573]
IC50 0.003Anti tumor activity against human splenic B-lympho blastoid Wil2-NS cells [AID219235, Type: Literature]
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