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BioActivity Data for Compound Dactinomycin (CID 457193)

BioActivity Outcomes:
Active(449)
 
 
Inactive(239)
 
 
Inconclusive(232)
 
 
Unspecified(615)
 
 
Top Targets:
7tm 4(33)
 
 
 
NR LBD PPAR(26)
 
 
 
 
p450(20)
 
 
 
 
 
NR LBD ER(20)
 
 
 
 
 
NR LBD AR(19)
 
 
 
 
 
BioAssay Types:
Literature(592)
 
 
 
 
 
Confirmatory(518)
 
 
 
 
 
Summary(48)
 
 
 
 
Screening(29)
 
 
 
BioAssay Categories:
In vitro(166)
 
 
 
In vivo(144)
 
 
Biochemical(209)
 
 
 
 
 
Toxicity(323)
 
 
 
 
 
ADME(64)
 
 
 
 
Cell-based(419)
 
 
 
 
 
BioActivity Types:
Potency(381)
 
 
 
 
IC50(232)
 
 
 
 
 
AC50(6)
 
 
EC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1130    Data Row: 1535   Total Pages: 77   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103579573]
IC50 8e-05Antitumor activity against CD4+ human acute T-lymphoblastic C8166 leukemia cells. [AID42389, Type: Literature]
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2
[SID103579573]
IC50 0.0002Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay [AID355583, Type: Literature]
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3
[SID103579573]
IC50 0.0004Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay [AID405551, Type: Literature]
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4
[SID103579573]
GI50 0.0007Growth inhibitory activity was tested against B104-1-1 cells [AID38501, Type: Literature]
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5
[SID144209680]
Potency-Replicate_1 0.0007qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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6
[SID103579573]
IC50 0.0008Cytotoxicity against human A2780 cells [AID403798, Type: Literature]
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7
[SID103579573]
IC50 0.0008Cytotoxicity against human A2780 cells [AID377761, Type: Literature]
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8
[SID103579573]
IC50 0.0008Antiproliferative activity against human C8166 cell line by MTT assay [AID269028, Type: Literature]
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9
[SID103579573]
IC50 0.0008Antitumor activity against CD+ human acute T-lymphoblastic leukemia C8166 cells [AID42388, Type: Literature]
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10
[SID103579573]
IC50 0.0009Antitumor activity against CD4+ human acute T-lymphoblastic MT-4 leukemia cells. [AID104318, Type: Literature]
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11
[SID103579573]
IC50 0.0009Antiproliferative activity against human MT4 cell line by MTT assay [AID269029, Type: Literature]
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12
[SID144209680]
Potency-Replicate_1 0.0009qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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13
[SID170464668]
IC50 0.001VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area decrease-IC50 [AID1117337, Type: confirmatory]
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14
[SID103579573]
ID50 0.001In vitro concentration required for growth inhibition of murine L1210 tumor cell [AID98677, Type: Literature]
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15
[SID103579573]
ID50 0.001In vitro cytotoxicity against L1210 cell line as concentration required for 50% inhibition of cell growth [AID96801, Type: Literature]
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16
[SID144209680]
Potency-Replicate_1 0.001qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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17
[SID103579573]
IC50 0.001Antitumor activity against human skin melanoma G-361 cells [AID72413, Type: Literature]
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18
[SID103579573]
IC50 0.001Antitumor activity against human skin melanoma G361 cells. [AID72414, Type: Literature]
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19
[SID103579573]
IC50 0.001Antitumor activity against human acute T-lymphoblastic leukemia CCRF-CEM cells [AID44012, Type: Literature]
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20
[SID103579573]
IC50 0.001Antitumor activity against human acute B-lymphoblastic CCRF-SB leukemia cells. [AID44371, Type: Literature]
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