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Dactinomycin (CID 457193) - Compound BioActivity Data
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BioActivity Outcomes:
Active(420)
 
 
Inactive(224)
 
 
Inconclusive(232)
 
 
Unspecified(527)
 
 
Top Targets:
NR LBD PPAR(26)
 
 
 
 
p450(20)
 
 
 
 
 
NR LBD ER(20)
 
 
 
 
 
NR LBD AR(19)
 
 
 
 
 
7TM GPCR Srsx(17)
 
 
 
BioAssay Types:
Confirmatory(508)
 
 
 
 
 
Literature(482)
 
 
 
 
 
Summary(48)
 
 
 
 
Screening(17)
 
 
 
BioActivity Types:
Potency(381)
 
 
 
 
IC50(222)
 
 
 
 
 
EC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 998    Data Row: 1403   Total Pages: 71   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103579573]
IC50 8e-05Antitumor activity against CD4+ human acute T-lymphoblastic C8166 leukemia cells. [AID42389, Type: Literature]
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2
[SID103579573]
IC50 0.0002Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay [AID355583, Type: Literature]
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3
[SID103579573]
IC50 0.0004Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay [AID405551, Type: Literature]
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4
[SID103579573]
GI50 0.0007Growth inhibitory activity was tested against B104-1-1 cells [AID38501, Type: Literature]
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5
[SID144209680]
Potency-Replicate_1 0.0007qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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6
[SID103579573]
IC50 0.0008Cytotoxicity against human A2780 cells [AID403798, Type: Literature]
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7
[SID103579573]
IC50 0.0008Cytotoxicity against human A2780 cells [AID377761, Type: Literature]
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8
[SID103579573]
IC50 0.0008Antiproliferative activity against human C8166 cell line by MTT assay [AID269028, Type: Literature]
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9
[SID103579573]
IC50 0.0008Antitumor activity against CD+ human acute T-lymphoblastic leukemia C8166 cells [AID42388, Type: Literature]
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10
[SID103579573]
IC50 0.0009Antitumor activity against CD4+ human acute T-lymphoblastic MT-4 leukemia cells. [AID104318, Type: Literature]
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11
[SID103579573]
IC50 0.0009Antiproliferative activity against human MT4 cell line by MTT assay [AID269029, Type: Literature]
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12
[SID144209680]
Potency-Replicate_1 0.0009qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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13
[SID144209680]
Potency-Replicate_1 0.001qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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14
[SID103579573]
IC50 0.001Antiproliferative activity against human CCRF-CEM cell line by MTT assay [AID269031, Type: Literature]
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15
[SID103579573]
IC50 0.001Antiproliferative activity against human G361 cell line by MTT assay [AID269032, Type: Literature]
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16
[SID103579573]
IC50 0.001Antiproliferative activity against human MOLT4 cell line by MTT assay [AID269026, Type: Literature]
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17
[SID103579573]
IC50 0.001Antiproliferative activity against human KB cell line by MTT assay [AID269038, Type: Literature]
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18
[SID103579573]
IC50 0.001Cytotoxicity against human HeLa cells in log-phase after 48 hrs by MTT assay [AID399050, Type: Literature]
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19
[SID103579573]
IC50 0.001Cytotoxicity against african green monkey Vero cells in log-phase after 48 hrs by MTT assay [AID399054, Type: Literature]
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20
[SID103579573]
IC50 0.001Antitumor activity against human CD4+T cells expressing the TAT gene of HTLV-1 MT-4 cells [AID104437, Type: Literature]
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