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BioActivity Data for Compound Ketoconazole (CID 456201)

BioActivity Outcomes:
Active(248)
 
 
Inactive(1338)
 
 
Inconclusive(222)
 
 
Unspecified(1348)
 
 
Top Targets:
7tm 4(99)
 
 
 
 
 
p450(78)
 
 
 
 
 
NR LBD PPAR(27)
 
 
 
NR LBD TR(20)
 
 
 
 
Bcl-2 like(20)
 
 
BioAssay Types:
Literature(1491)
 
 
 
 
 
Confirmatory(879)
 
 
 
 
 
Screening(654)
 
 
 
 
Summary(44)
 
 
 
 
BioAssay Categories:
In vitro(195)
 
 
 
 
In vivo(11)
 
 
 
 
Biochemical(338)
 
 
 
 
 
Toxicity(67)
 
 
 
 
 
ADME(136)
 
 
 
 
Cell-based(301)
 
 
 
 
 
Organism-base..(16)
 
 
 
BioActivity Types:
Potency(700)
 
 
 
 
 
IC50(246)
 
 
 
 
 
EC50(17)
 
 
 
AC50(8)
 
 
 
Kd(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2567    Data Row: 3156   Total Pages: 158   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169669]
EC50 0.0003Antitrypanosomal activity against Trypanosoma cruzi Tulahuen amastigotes expressing beta-galactosidase in mouse 3T3 fibroblast after 7 days by alamar blue assay [AID394826, Type: Literature]
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2
[SID103169669]
IC50 0.00071Displacement of [131I]IMTO from CYP450c 11 in Wistar rat adrenal membrane [AID327555, Type: Literature]
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3
[SID103169669]
IC50 0.004Inhibition of human CYP3A4 [AID449589, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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4
[SID103169669]
IC50 0.0078Inhibition of CYP3A4 after 30 mins by fluorometric assay [AID568746, Type: Literature]
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5
[SID103169669]
IC50 0.01Antifungal activity against Candida albicans ATCC 14053 after 48 hrs by CLSI method [AID531205, Type: Literature]
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6
[SID103169669]
IC50 0.01Antifungal activity against Candida albicans ATCC 60193 after 48 hrs by CLSI method [AID531206, Type: Literature]
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7
[SID103169669]
IC50 0.01Antifungal activity against Fluconazole resistant Candida albicans clinical isolate 1 after 48 hrs by CLSI method [AID530970, Type: Literature]
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8
[SID103169669]
IC50 0.01Antifungal activity against Candida albicans ATCC 200955 after 48 hrs by CLSI method [AID530981, Type: Literature]
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9
[SID103169669]
IC50 0.01Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by CLSI method [AID530988, Type: Literature]
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10
[SID103169669]
IC50 0.01Antifungal activity against Candida albicans ATCC 32354 after 48 hrs by CLSI method [AID531183, Type: Literature]
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11
[SID103169669]
IC50 0.01Antifungal activity against Trichophyton rubrum ATCC MYA-4438 by CLSI method [AID530947, Type: Literature]
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12
[SID103169669]
IC50 0.011Inhibition of human recombinant CYP3A4 [AID480595, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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13
[SID103169669]
IC50 0.013Inhibition of recombinant human Cytochrome P450 3A4 with BFC [7-benzyloxy-4-trifluoromethylcoumarin] after 15 minutes [AID54780, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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14
[SID103169669]
IC50 0.016Inhibition of recombinant human Cytochrome P450 3A4 with BFC [7-benzyloxy-4-trifluoromethylcoumarin] after 5 minutes [AID54783, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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15
[SID103169669]
IC50 0.017Inhibition of recombinant human Cytochrome P450 3A4 using BFC [7-benzyloxy-4-trifluoromethylcoumarin] after 30 minutes [AID54781, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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16
[SID103169669]
IC50 0.02Inhibition of CYP3A4 in human liver microsome [AID340017, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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17
[SID103169669]
IC50 0.02Antifungal activity against Trichophyton rubrum ATCC 10218 by CLSI method [AID530941, Type: Literature]
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18
[SID103169669]
IC50 0.02Antifungal activity against Cryptococcus neoformans ATCC 66031 after 72 hrs by CLSI method [AID530958, Type: Literature]
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19
[SID103169669]
IC50 0.022Inhibition of recombinant human Cytochrome P450 3A4 with BFC [7-benzyloxy-4-trifluoromethylcoumarin] after 45 minutes [AID54782, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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20
[SID103169669]
IC50 0.037Inhibition of cellular cholesterol biosynthesis using human fibroblasts in tissue culture [AID89415, Type: Literature]
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