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BioActivity Data for Compound NS 2028 (CID 4551)

BioActivity Outcomes:
Active(4)
 
 
Inactive(209)
 
 
Inconclusive(26)
 
 
Unspecified(3)
 
 
Top Targets:
p450(9)
 
 
 
 
7tm 4(8)
 
 
Pyr redox dim(5)
 
 
GH27(5)
 
 
Pyruvate Kina..(4)
 
 
 
BioAssay Types:
Confirmatory(206)
 
 
 
 
 
Screening(13)
 
 
Literature(7)
 
 
 
 
Summary(1)
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(3)
 
 
 
Toxicity(4)
 
 
Cell-based(4)
 
 
BioActivity Types:
Potency(184)
 
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 215    Data Row: 242   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103602921]
IC50 0.036Inhibition of guanylate cyclase [AID340322, Type: Literature]
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2
[SID103602921]
Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay [AID521220, Type: Literature]
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3
[SID11111516]
Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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4
[SID11111516]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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5
[SID11111516]
Potency 6.3096qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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6
[SID50106785]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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7
[SID11111516]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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8
[SID11111516]
Potency 0.0126qHTS Assay for Activators of Human Muscle Pyruvate Kinase [AID954, Type: confirmatory]pyruvate kinase PKM isoform b [Homo sapiens] [gi:33286420]
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9
[SID50106785]
Potency 0.0224qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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10
[SID90341337]
Potency 3.9811qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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11
[SID11111516]
Potency 7.9433qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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12
[SID85231148]
Potency 10qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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13
[SID11111516]
Potency 19.9526qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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14
[SID50106785]
Potency 19.9526qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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15
[SID90341337]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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16
[SID90341337]
Potency qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay [AID588349, Type: confirmatory]
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17
[SID50106785]
Potency qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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18
[SID50106785]
qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Validation Screen for Agonists [AID493127, Type: screening]thyrotropin-releasing hormone receptor [Homo sapiens] [gi:4507681]
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19
[SID17405480]
HTS for 14-3-3 protein interaction modulators [AID422, Type: screening]14-3-3 protein gamma [Homo sapiens] [gi:21464101]
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20
[SID90341337]
Potency qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2 [AID488837, Type: confirmatory]eyes absent homolog 2 isoform a [Homo sapiens] [gi:26667227]
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