Bookmark and Share
AGN-PC-07C6UJ (CID 45272995) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(1)
 
 
Unspecified(3)
 
 
Top Targets:
Rac1 like(8)
 
 
 
Cdc42(1)
 
 
RhoA like(1)
 
 
BioAssay Types:
Literature(10)
 
 
 
 
BioActivity Types:
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 10    Data Row: 10   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103692690]
IC50 12.2Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISA [AID421036, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
View
2
[SID103692690]
Inhibition of PDGF-BB-stimulated Rac1-mediated cellular events in mouse 3T3 cells assessed as induction of membrane lamillipodia at 25 uM after 48 hrs by fluorescent microscopy [AID421044, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702788]
View
3
[SID103692690]
Inhibition of PDGF-BB-stimulated Rac1-mediated cellular events in mouse 3T3 cells assessed as induction of membrane ruffling formation at 25 uM after 48 hrs by fluorescent microscopy [AID421045, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702788]
View
4
[SID103692690]
Inhibition of PDGF-BB-stimulated Rac1 activity assessed as blockade of Rac1-Tiam1 interaction in human aortic smooth muscle cells at 50 uM by SDS-PAGE based chemiluminescence [AID421041, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
View
5
[SID103692690]
Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 50 uM by SDS-PAGE based chemiluminescence [AID421042, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
View
6
[SID103692690]
Inhibition of Rac1 binding to Pak1 in human aortic smooth muscle cells at 100 uM by SDS-PAGE based chemiluminescence [AID421043, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
View
7
[SID103692690]
Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level at 50 uM after 4 hrs by G-LISA relative to control [AID421035, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
View
8
[SID103692690]
Inhibition of PDGF-BB-stimulated Cdc42 activity in human aortic smooth muscle cells assessed as reduction in ratio of Cdc42GTP/Cdc42 levels at 25 uM after 4 hrs by pull-down assay [AID421039, Type: Literature]Cell division control protein 42 homolog [gi:322510015]
View
9
[SID103692690]
Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of ratio of Rac1GTP/Rac1 levels at 25 uM after 4 hrs by pull-down assay [AID421037, Type: Literature]Ras-related C3 botulinum toxin substrate 1 [gi:51702787]
View
10
[SID103692690]
Inhibition of PDGF-BB-stimulated RhoA activity in human aortic smooth muscle cells assessed as reduction in ratio of RhoAGTP/RhoA levels at 25 uM after 4 hrs by pull-down assay [AID421040, Type: Literature]Transforming protein RhoA [gi:47606458]
View