CHEMBL558934 (CID 45270515) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Unspecified(5)
 
 
Top Targets:
SLC5sbd SGLT1(1)
 
 
SLC5sbd SGLT2(1)
 
 
BioAssay Types:
Literature(5)
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 5    Data Row: 5   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103687727]
 Vasodilation activity in Wistar rat endothelium-intact thoracic aortic ring assessed as inhibition of phenylepinephrine-induced contraction at 30 uM [AID422397, Type: Literature]
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2
[SID103687727]
 Cytotoxicity against human HeLa cells [AID422396, Type: Literature]
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3
[SID103687727]
 Antiplasmodial activity against Plasmodium falciparum 3D7 infected human erythrocytes by Giemsa staining [AID422395, Type: Literature]
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4
[SID103687727]
 Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT1 expressed in african green monkey COS1 cells at 50 uM after 30 mins by liquid scintillation counting [AID462409, Type: Literature]Sodium/glucose cotransporter 1 [gi:127803]
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5
[SID103687727]
 Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT2 expressed in african green monkey COS1 cells at 50 uM after 30 mins by liquid scintillation counting [AID462410, Type: Literature]Sodium/glucose cotransporter 2 [gi:400337]
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