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CHEMBL563341 (CID 45269449) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Unspecified(16)
 
 
Top Targets:
NR LBD PR(2)
 
 
 
CAP ED(1)
 
 
BioAssay Types:
Literature(20)
 
 
 
BioActivity Types:
IC50(3)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 20    Data Row: 20   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103685319]
IC50 0.015Binding affinity to progesterone receptor [AID434178, Type: Literature]
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2
[SID103685319]
EC50 0.03Agonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity [AID434184, Type: Literature]Progesterone receptor [gi:90110048]
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3
[SID103685319]
IC50 0.25Binding affinity to androgen receptor [AID434179, Type: Literature]
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4
[SID103685319]
IC50 0.78Inhibition of human ERG by whole cell patch clamp assay [AID434233, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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5
[SID103685319]
Agonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity relative to progesterone [AID434237, Type: Literature]Progesterone receptor [gi:90110048]
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6
[SID103685319]
Selectivity for progesterone receptor over estrogen receptor [AID434181, Type: Literature]
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7
[SID103685319]
Selectivity for progesterone receptor over mineralocorticoid receptor [AID434182, Type: Literature]
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8
[SID103685319]
Selectivity for progesterone receptor over glucocorticoid receptor [AID434183, Type: Literature]
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9
[SID103685319]
Plasma clearance in rat at 1.9 mg/kg, po [AID434185, Type: Literature]
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10
[SID103685319]
Volume of distribution at steady state in rat at 1.1 mg/kg, iv or 1.9 mg/kg, po [AID434190, Type: Literature]
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11
[SID103685319]
Cmax in rat at 1.9 mg/kg, po [AID434195, Type: Literature]
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12
[SID103685319]
AUC (0 to t) in rat at 1.9 mg/kg, po [AID434200, Type: Literature]
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13
[SID103685319]
Half life in rat at 1.9 mg/kg, po [AID434205, Type: Literature]
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14
[SID103685319]
Oral bioavailability in rat at 1.9 mg/kg [AID434210, Type: Literature]
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15
[SID103685319]
Plasma clearance in monkey at 4 mg/kg, po [AID434215, Type: Literature]
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16
[SID103685319]
Volume of distribution at steady state in monkey at 2.1 mg/kg, iv or 4 mg/kg, po [AID434218, Type: Literature]
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17
[SID103685319]
Cmax in monkey at 4 mg/kg, po [AID434221, Type: Literature]
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18
[SID103685319]
AUC (0 to t) in monkey at 4 mg/kg, po [AID434224, Type: Literature]
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19
[SID103685319]
Half life in monkey at 4 mg/kg, po [AID434227, Type: Literature]
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20
[SID103685319]
Oral bioavailability in monkey at 4 mg/kg, po [AID434230, Type: Literature]
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