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Nitroglycerin (CID 4510) - Compound BioActivity Data
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BioActivity Outcomes:
Active(24)
 
 
Inactive(7)
 
 
Inconclusive(16)
 
 
Unspecified(62)
 
 
Top Targets:
HNOBA(4)
 
 
NAD binding 8(1)
 
 
Sulfatase(1)
 
 
BioAssay Types:
Literature(99)
 
 
 
 
 
BioActivity Types:
IC50(21)
 
 
 
 
EC50(13)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 106    Data Row: 109   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103198242]
EC50 0.007In vitro vascular relaxation in canine mesenteric veins precontracted with phenylephrine. [AID218881, Type: Literature]
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2
[SID103198242]
EC50 0.01In vitro vascular relaxation in canine coronary arteries precontracted with prostaglandin F2alpha. [AID218879, Type: Literature]
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3
[SID103198242]
IC50 0.016Vasorelaxation activity in the isolated endothelium-denuded rabbit aorta [AID167355, Type: Literature]
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4
[SID103198242]
EC50 0.022Capacity to increase [Ca2+] entry into the vascular smooth muscle was evaluated on rat aorta strips partially depolarized with 50 mM K [AID175471, Type: Literature]
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5
[SID103198242]
EC50 0.0224Relaxation of endothelium denucleated strips of rat aorta precontracted with noradrenaline [AID195179, Type: Literature]
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6
[SID103198242]
EC50 0.027Vasorelaxant activity in pig pulmonary artery by organ bath experiment [AID352262, Type: Literature]
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7
[SID103198242]
EC50 0.029Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction [AID374757, Type: Literature]
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8
[SID103198242]
EC50 0.0356Vasodilatory effect in pig pulmonary artery assessed as inhibition of PGF2-alpha-induced contraction [AID309710, Type: Literature]
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9
[SID103198242]
IC50 0.05888Vasorelaxant activity in endothelium-denuded Wistar rat thoracic aortic ring assessed as inhibition of KCl-induced contraction [AID437027, Type: Literature]
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10
[SID103198242]
IC50 0.12589Vasorelaxant activity in Wistar rat endothelium-removed thoracic aortic rings assessed as reduction of KCl-induced vasoconstriction treated after KCl-challenge [AID733826, Type: Literature]
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11
[SID103198242]
IC50 0.12589Vasorelaxation activity against KCl-induced contraction in isolated Wistar rat thoracic endothelium-denulated aortic rings [AID641620, Type: Literature]
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12
[SID103198242]
EC50 0.42Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction drug treated 30 mins after ALDH2 inhibitor benomyl treatment [AID374758, Type: Literature]
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13
[SID103198242]
EC50 0.94Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction drug treated 30 mins after ALDH2 inhibitor chloral hydrate treatment [AID374759, Type: Literature]
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14
[SID103198242]
EC50 1.9Effective concentration for relaxation of isolated rat aortic strips, submaximally contracted with phenylephrine at 0.1 uM was determined [AID175666, Type: Literature]
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15
[SID103198242]
EC50 2.2Compound was tested for its vasodilator effects on endothelium-denuded strips of rat aorta precontracted with noradrenaline [AID175492, Type: Literature]
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16
[SID103198242]
EC50 4.4Vasodilatory activity in Wistar rat endothelium-denuded cross tolerant thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction preincubated with 0.55 mM GTN for 1 hr followed by washing [AID374756, Type: Literature]
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17
[SID103198242]
Induction of NO release in Wistar rat liver homogenate at 200 uM by amperometric detection method [AID437026, Type: Literature]
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18
[SID103198242]
Soluble guanylate cyclase activator [AID742506, Type: other]Guanylate cyclase soluble subunit beta-1 [gi:399328]
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19
[SID103198242]
Soluble guanylate cyclase activator [AID742506, Type: other]Guanylate cyclase soluble subunit alpha-2 [gi:461897]
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20
[SID103198242]
Soluble guanylate cyclase activator [AID742506, Type: other]Guanylate cyclase soluble subunit alpha-3 [gi:7404351]
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