Nitroglycerin (CID 4510) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(19)
 
 
Inactive(5)
 
 
Inconclusive(16)
 
 
Unspecified(59)
 
 
BioAssay Types:
Literature(95)
 
 
 
 
 
BioActivity Types:
IC50(19)
 
 
 
EC50(13)
 
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 99    Data Row: 99   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103198242]
EC50 0.007In vitro vascular relaxation in canine mesenteric veins precontracted with phenylephrine. [AID218881, Type: Literature]
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2
[SID103198242]
EC50 0.01In vitro vascular relaxation in canine coronary arteries precontracted with prostaglandin F2alpha. [AID218879, Type: Literature]
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3
[SID103198242]
IC50 0.016Vasorelaxation activity in the isolated endothelium-denuded rabbit aorta [AID167355, Type: Literature]
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4
[SID103198242]
EC50 0.022Capacity to increase [Ca2+] entry into the vascular smooth muscle was evaluated on rat aorta strips partially depolarized with 50 mM K [AID175471, Type: Literature]
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5
[SID103198242]
EC50 0.0224Relaxation of endothelium denucleated strips of rat aorta precontracted with noradrenaline [AID195179, Type: Literature]
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6
[SID103198242]
EC50 0.027Vasorelaxant activity in pig pulmonary artery by organ bath experiment [AID352262, Type: Literature]
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7
[SID103198242]
EC50 0.029Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction [AID374757, Type: Literature]
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8
[SID103198242]
EC50 0.0356Vasodilatory effect in pig pulmonary artery assessed as inhibition of PGF2-alpha-induced contraction [AID309710, Type: Literature]
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9
[SID103198242]
IC50 0.05888Vasorelaxant activity in endothelium-denuded Wistar rat thoracic aortic ring assessed as inhibition of KCl-induced contraction [AID437027, Type: Literature]
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10
[SID103198242]
IC50 0.12589Vasorelaxation activity against KCl-induced contraction in isolated Wistar rat thoracic endothelium-denulated aortic rings [AID641620, Type: Literature]
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11
[SID103198242]
EC50 0.42Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction drug treated 30 mins after ALDH2 inhibitor benomyl treatment [AID374758, Type: Literature]
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12
[SID103198242]
EC50 0.94Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction drug treated 30 mins after ALDH2 inhibitor chloral hydrate treatment [AID374759, Type: Literature]
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13
[SID103198242]
EC50 1.9Effective concentration for relaxation of isolated rat aortic strips, submaximally contracted with phenylephrine at 0.1 uM was determined [AID175666, Type: Literature]
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14
[SID103198242]
EC50 2.2Compound was tested for its vasodilator effects on endothelium-denuded strips of rat aorta precontracted with noradrenaline [AID175492, Type: Literature]
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15
[SID103198242]
EC50 4.4Vasodilatory activity in Wistar rat endothelium-denuded cross tolerant thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction preincubated with 0.55 mM GTN for 1 hr followed by washing [AID374756, Type: Literature]
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16
[SID103198242]
 Induction of NO release in Wistar rat liver homogenate at 200 uM by amperometric detection method [AID437026, Type: Literature]
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17
[SID48414597]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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18
[SID48414597]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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19
[SID48414597]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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20
[SID103198242]
EC50 100Vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction drug treated 30 mins after 1 uM soluble guanylate cyclase heme site inhibitor ODQ treatment [AID374760, Type: Literature]
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21
[SID103198242]
 Ratio of EC50 for vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring in presence of benomyl to EC50 for vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring [AID374762, Type: Literature]
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22
[SID103198242]
 Ratio of EC50 for vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring in presence of chloral hydrate to EC50 for vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring [AID374763, Type: Literature]
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23
[SID103198242]
 Ratio of EC50 for vasodilatory activity in Wistar rat endothelium-denuded cross tolerant thoracic aortic ring preincubated with 0.55 mM GTN for 1 hr followed by washing to EC50 for vasodilatory activity in Wistar rat endothelium-denuded thoracic aortic ring [AID374764, Type: Literature]
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24
[SID103198242]
 Cardiac protection in Wistar rat assessed as decrease in infarct size at 5 ug/min/kg for 13 hrs prolonged treatment terminated 3 hrs before ischemia [AID395247, Type: Literature]
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25
[SID103198242]
 Permeability coefficient in human skin [AID311367, Type: Literature]
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26
[SID103198242]
 Anticarcinogenic activity in rat assessed as induction of tumors per day [AID318681, Type: Literature]
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27
[SID103198242]
 Nitric oxide release in PBS at pH 7.4 in 37 degC after 1.5 hrs [AID321898, Type: Literature]
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28
[SID103198242]
 Nitric oxide release in PBS in presence of 5 mM L-cysteine at pH 7.4 in 37 degC after 1.5 hrs [AID321900, Type: Literature]
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29
[SID103198242]
 Nitric oxide release in phosphate buffer containing 5 mM L-cysteine at pH 7.4 incubated at 34 degC after 1.5 hrs [AID352494, Type: Literature]
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30
[SID103198242]
 Nitric oxide release in phosphate buffer at pH 7.4 incubated at 34 degC after 1.5 hrs [AID352500, Type: Literature]
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31
[SID103198242]
 Induction of NO release in phosphate buffer at pH 7.4 [AID457931, Type: Literature]
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32
[SID103198242]
 Induction of NO release in presence of 5 mM L-cysteine [AID457932, Type: Literature]
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33
[SID103198242]
 Percent change in left ventricle contractile force in anesthetized dogs after intravenous administration at 0.3 mg/kg [AID58416, Type: Literature]
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34
[SID103198242]
 Percent change in left ventricle contractile force in anesthetized dogs after intravenous administration at 1.0 mg/kg [AID58418, Type: Literature]
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35
[SID103198242]
 Percent change in left ventricle contractile force in anesthetized dogs after intravenous administration at 3.0 mg/kg [AID58420, Type: Literature]
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36
[SID103198242]
 Maximum hypertension was measured in anesthetized dog as percent at the dose of 0.03 mg/kg, i.v. [AID59574, Type: Literature]
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37
[SID103198242]
 Maximum collateral index in anesthetized dog at the dose of 0.03 mg/kg, i.v. [AID59741, Type: Literature]
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38
[SID103198242]
 Collateral index in anesthetized dog at the dose of 0.03 mg/kg, i.v. after 60 minutes of administration [AID60299, Type: Literature]
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39
[SID103198242]
 Percent change in mean arterial blood pressure after intravenous administration in anesthetized dogs at 0.3 mg/kg [AID60813, Type: Literature]
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40
[SID103198242]
 Percent change in mean arterial blood pressure after intravenous administration in anesthetized dogs at 1.0 mg/kg [AID60814, Type: Literature]
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41
[SID103198242]
 Percent change in mean arterial blood pressure after intravenous administration in anesthetized dogs at 3.0 mg/kg [AID60816, Type: Literature]
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42
[SID103198242]
 Percent change heart rate after intravenous administration in anesthetized dogs at 0.3 mg/kg (NC<10%) [AID60819, Type: Literature]
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43
[SID103198242]
 Percent change heart rate after intravenous administration in anesthetized dogs at 1.0 mg/kg [AID60820, Type: Literature]
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44
[SID103198242]
 Percent change in heart rate after intravenous administration in anesthetized dogs at 3.0 mg/kg (NC<10%) [AID60821, Type: Literature]
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45
[SID103198242]
 In vitro NO (nitrous oxide) release by nitrite quanititation using Griess reaction without N-acetyl-cysteamine [AID76451, Type: Literature]
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46
[SID103198242]
 In vitro NO (nitrous oxide) release by nitrite quanititation using Griess reaction in presence of N-acetyl-cysteamine [AID76452, Type: Literature]
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47
[SID103198242]
 In vitro release of nitric oxide by nitrite quantitation in the absence of N-acetyl-cysteamine by Griess reaction [AID77510, Type: Literature]
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48
[SID103198242]
 In vitro release of nitric oxide by nitrite quantitation in the presence of N-acetyl-cysteamine by Griess reaction [AID77511, Type: Literature]
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49
[SID103198242]
 In vitro nitric oxide release incubated in the absenceof N-acetyl-cysteamine in phosphate buffer [AID77513, Type: Literature]
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50
[SID103198242]
 In vitro nitric oxide release incubated in the presence of N-acetyl-cysteamine in phosphate buffer [AID77514, Type: Literature]
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