4-hydroxytamoxifen (CID 449459) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(109)
 
 
Inactive(602)
 
 
Inconclusive(48)
 
 
Unspecified(82)
 
 
Top Targets:
NR LBD ER(41)
 
 
 
 
 
7TM GPCR Srx(19)
 
 
NR LBD PPAR(14)
 
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
BioAssay Types:
Screening(482)
 
 
 
 
Confirmatory(190)
 
 
 
 
 
Literature(140)
 
 
 
 
 
BioActivity Types:
Potency(136)
 
 
 
 
 
IC50(72)
 
 
 
 
EC50(13)
 
 
 
Ki(10)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 761    Data Row: 841   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169566]
Ki 1.4e-05Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiol [AID254433, Type: Literature]Estrogen receptor beta [gi:6166154]
View
2
[SID103169566]
Ki 1.4e-05Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiol [AID254433, Type: Literature]Estrogen receptor beta [gi:6166154]
View
3
[SID103169566]
Ki 1.4e-05Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiol [AID254433, Type: Literature]Estrogen receptor beta [gi:6166154]
View
4
[SID103169566]
EC50 3e-05Effective dose for [3H]- estradiol against proliferation of MCF-7 cells [AID102435, Type: Literature]
View
5
[SID103169566]
Ki 4e-05Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiol [AID254436, Type: Literature]Estrogen receptor [gi:544257]
View
6
[SID103169566]
Ki 4e-05Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiol [AID254436, Type: Literature]Estrogen receptor [gi:544257]
View
7
[SID103169566]
Ki 4e-05Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiol [AID254436, Type: Literature]Estrogen receptor [gi:544257]
View
8
[SID103169566]
Ki 4e-05Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiol [AID254436, Type: Literature]Estrogen receptor [gi:544257]
View
9
[SID103169566]
EC50 0.00012Effective concentration against MCF-7 breast tumor cells using MCF-7 assay. [AID103375, Type: Literature]
View
10
[SID103169566]
Ki 0.00016In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor beta [AID70164, Type: Literature]Estrogen receptor beta [gi:6166154]
View
11
[SID103169566]
Ki 0.00016In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor beta [AID70164, Type: Literature]Estrogen receptor beta [gi:6166154]
View
12
[SID103169566]
Ki 0.00016In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor beta [AID70164, Type: Literature]Estrogen receptor beta [gi:6166154]
View
13
[SID103169566]
Ki 0.000249Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor [gi:544257]
View
14
[SID103169566]
Ki 0.000249Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor [gi:544257]
View
15
[SID103169566]
Ki 0.000249Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor [gi:544257]
View
16
[SID103169566]
Ki 0.000249Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor [gi:544257]
View
17
[SID103169566]
Ki 0.00025In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor alpha [AID70002, Type: Literature]Estrogen receptor [gi:544257]
View
18
[SID103169566]
Ki 0.00025In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor alpha [AID70002, Type: Literature]Estrogen receptor [gi:544257]
View
19
[SID103169566]
Ki 0.00025In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor alpha [AID70002, Type: Literature]Estrogen receptor [gi:544257]
View
20
[SID103169566]
Ki 0.00025In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor alpha [AID70002, Type: Literature]Estrogen receptor [gi:544257]
View
21
[SID103169566]
Ki 0.000346Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor [gi:544257]
View
22
[SID103169566]
Ki 0.000346Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor [gi:544257]
View
23
[SID103169566]
Ki 0.000346Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor [gi:544257]
View
24
[SID103169566]
Ki 0.000346Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor [gi:544257]
View
25
[SID103169566]
Ki 0.00039Displacement of [3H]estradiol from ERalpha after 4 hrs by scintillation counting [AID669588, Type: Literature]
View
26
[SID103169566]
IC50 0.0005Antiproliferative activity against human MCF7 cells [AID658133, Type: Literature]
View
27
[SID103169566]
IC50 0.0005Inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102593, Type: Literature]
View
28
[SID103169566]
IC50 0.0005Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-estradiol (in vitro) [AID103888, Type: Literature]
View
29
[SID103169566]
IC50 0.00117Inhibition of estrogen-induced proliferation in human MCF-7 breast cancer cells [AID103267, Type: Literature]
View
30
[SID103169566]
Ki 0.0017Binding affinity towards human estrogen receptor beta in a competitive binding assay using fluorescently labelled estradiol [AID254435, Type: Literature]Estrogen receptor beta [gi:6166154]
View
31
[SID103169566]
Ki 0.0017Binding affinity towards human estrogen receptor beta in a competitive binding assay using fluorescently labelled estradiol [AID254435, Type: Literature]Estrogen receptor beta [gi:6166154]
View
32
[SID103169566]
Ki 0.0017Binding affinity towards human estrogen receptor beta in a competitive binding assay using fluorescently labelled estradiol [AID254435, Type: Literature]Estrogen receptor beta [gi:6166154]
View
33
[SID103169566]
IC50 0.0019Ability to inhibit release of interleukin-6 from U2OS cell lines transfected with estrogen receptor alpha [AID214256, Type: Literature]
View
34
[SID103169566]
IC50 0.002Displacement of [3H]estradiol from ERalpha [AID260520, Type: Literature]Estrogen receptor [gi:544257]
View
35
[SID103169566]
IC50 0.002Displacement of [3H]estradiol from ERalpha [AID260520, Type: Literature]Estrogen receptor [gi:544257]
View
36
[SID103169566]
IC50 0.002Displacement of [3H]estradiol from ERalpha [AID260520, Type: Literature]Estrogen receptor [gi:544257]
View
37
[SID103169566]
IC50 0.002Displacement of [3H]estradiol from ERalpha [AID260520, Type: Literature]Estrogen receptor [gi:544257]
View
38
[SID103169566]
IC50 0.0025In vitro inhibition of MCF-7 cell proliferation compared to 0.1 nM [3H]-estradiol. [AID102602, Type: Literature]
View
39
[SID103169566]
IC50 0.003Anti-estrogenicity for 50% inhibition of the MVLN cell luciferase activity due to 0.1 nM E2 (estradiol) [AID106081, Type: Literature]
View
40
[SID103169566]
Ki 0.0057Binding affinity towards human estrogen receptor alpha in a competitive binding assay using fluorescently labelled estradiol [AID254437, Type: Literature]Estrogen receptor [gi:544257]
View
41
[SID103169566]
Ki 0.0057Binding affinity towards human estrogen receptor alpha in a competitive binding assay using fluorescently labelled estradiol [AID254437, Type: Literature]Estrogen receptor [gi:544257]
View
42
[SID103169566]
Ki 0.0057Binding affinity towards human estrogen receptor alpha in a competitive binding assay using fluorescently labelled estradiol [AID254437, Type: Literature]Estrogen receptor [gi:544257]
View
43
[SID103169566]
Ki 0.0057Binding affinity towards human estrogen receptor alpha in a competitive binding assay using fluorescently labelled estradiol [AID254437, Type: Literature]Estrogen receptor [gi:544257]
View
44
[SID103169566]
EC50 0.006In vitro displacement of 3 nM [3H]4-hydroxytamoxifen from estrogen receptor of rat uterine cystol [AID69376, Type: Literature]Estrogen receptor [gi:119600]
View
45
[SID103169566]
IC50 0.007Inhibition of estradiol induced estrogen receptor transcriptional activation in MCF-7-2a cells [AID103082, Type: Literature]Estrogen receptor [gi:544257]
View
46
[SID103169566]
IC50 0.007Inhibition of estradiol induced estrogen receptor transcriptional activation in MCF-7-2a cells [AID103082, Type: Literature]Estrogen receptor [gi:544257]
View
47
[SID103169566]
IC50 0.007Inhibition of estradiol induced estrogen receptor transcriptional activation in MCF-7-2a cells [AID103082, Type: Literature]Estrogen receptor [gi:544257]
View
48
[SID103169566]
IC50 0.007Inhibition of estradiol induced estrogen receptor transcriptional activation in MCF-7-2a cells [AID103082, Type: Literature]Estrogen receptor [gi:544257]
View
49
[SID103169566]
IC50 0.0085Inhibitory concentration against MCF-7 breast tumor cells using MCF-7 assay. [AID103376, Type: Literature]
View
50
[SID103169566]
IC50 0.0085Antiproliferative activity against human MCF7 cells after 24 hrs by MTS assay [AID392053, Type: Literature]
View