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afimoxifene (CID 449459) - Compound BioActivity Data
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BioActivity Outcomes:
Active(171)
 
 
Inactive(726)
 
 
Inconclusive(98)
 
 
Unspecified(114)
 
 
Top Targets:
NR LBD ER(87)
 
 
 
 
 
7tm 4(42)
 
 
NR LBD PPAR(22)
 
 
 
NR LBD TR(11)
 
 
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Screening(558)
 
 
 
 
Confirmatory(284)
 
 
 
 
 
Literature(220)
 
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(241)
 
 
 
 
 
IC50(90)
 
 
 
 
EC50(16)
 
 
 
Ki(14)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 914    Data Row: 1109   Total Pages: 56   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169566]
Ki 1.4e-05Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiol [AID254433, Type: Literature]Estrogen receptor beta [gi:6166154]
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2
[SID103169566]
EC50 3e-05Effective dose for [3H]- estradiol against proliferation of MCF-7 cells [AID102435, Type: Literature]
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3
[SID103169566]
Ki 4e-05Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiol [AID254436, Type: Literature]Estrogen receptor [gi:544257]
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4
[SID103169566]
EC50 0.00012Effective concentration against MCF-7 breast tumor cells using MCF-7 assay. [AID103375, Type: Literature]
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5
[SID103169566]
Ki 0.00016In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor beta [AID70164, Type: Literature]Estrogen receptor beta [gi:6166154]
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6
[SID103169566]
Ki 0.000249Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor beta [gi:6166154]
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7
[SID103169566]
Ki 0.000249Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor [gi:544257]
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8
[SID103169566]
Ki 0.00025In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor alpha [AID70002, Type: Literature]Estrogen receptor [gi:544257]
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9
[SID103169566]
Ki 0.000346Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor [gi:544257]
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10
[SID103169566]
Ki 0.000346Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor beta [gi:6166154]
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11
[SID103169566]
Ki 0.00039Displacement of [3H]estradiol from ERalpha after 4 hrs by scintillation counting [AID669588, Type: Literature]
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12
[SID103169566]
Ki 0.0005Binding affinity for estrogen receptor beta [AID70658, Type: Literature]Estrogen receptor beta [gi:6166154]
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13
[SID103169566]
Ki 0.0005Binding affinity for estrogen receptor alpha [AID70347, Type: Literature]Estrogen receptor [gi:544257]
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14
[SID103169566]
IC50 0.0005Antiproliferative activity against human MCF7 cells [AID658133, Type: Literature]
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15
[SID103169566]
IC50 0.0005Inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102593, Type: Literature]
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16
[SID103169566]
IC50 0.0005Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-estradiol (in vitro) [AID103888, Type: Literature]
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17
[SID103169566]
EC50 0.0008Agonist activity as alkaline phosphatase induction in Ishikawa endometrial cells compared to E2 [AID246597, Type: Literature]Estrogen receptor [gi:544257]
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18
[SID103169566]
EC50 0.0008Agonist activity as alkaline phosphatase induction in Ishikawa endometrial cells compared to E2 [AID246597, Type: Literature]Estrogen receptor beta [gi:6166154]
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19
[SID103169566]
IC50 0.00117Inhibition of estrogen-induced proliferation in human MCF-7 breast cancer cells [AID103267, Type: Literature]
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20
[SID103169566]
IC50 0.00158pIC50 for 1 nM estradiol-induced Ishikawa cell proliferation [AID249539, Type: Literature]Estrogen receptor beta [gi:6166154]
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