alitretinoin (CID 449171) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(161)
 
 
Top Targets:
NR LBD RXR li..(28)
 
 
NR LBD RAR(19)
 
 
NR LBD VDR(3)
 
 
NR DBD COUP T..(1)
 
 
NR LBD(1)
 
 
BioAssay Types:
Literature(112)
 
 
Screening(18)
 
 
Confirmatory(4)
 
 
BioActivity Types:
EC50(65)
 
 
Kd(36)
 
 
Ki(16)
 
 
IC50(11)
 
 
Potency(4)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 143    Data Row: 161   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103194296]
Ki 0.0005Binding affinity towards cRAR-beta-2 receptor by displacing 1.1 nM 3[H]-9-cis-RA [AID220310, Type: other]
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2
[SID103194296]
Ki 0.0007Binding affinity towards cRAR-beta-2 receptor by displacing 0.82 nM 3[H]all-trans-RA [AID220308, Type: other]
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3
[SID103194296]
Kd 0.0008Dissociation constant for Retinoic acid receptor gamma [AID254257, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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4
[SID103194296]
Kd 0.0008Dissociation constant for Retinoic acid receptor gamma [AID254257, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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5
[SID103194296]
Ki 0.001Agonistic activity towards retinoic acid receptor-gamma [AID198732, Type: Literature]
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6
[SID103194296]
EC50 0.0015Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha [AID167582, Type: Literature]
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7
[SID103194296]
Kd 0.0015Dissociation constant for Retinoid X receptor alpha [AID254256, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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8
[SID103194296]
Kd 0.0015Dissociation constant for Retinoid X receptor alpha [AID254256, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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9
[SID103194296]
Kd 0.0015Dissociation constant for Retinoid X receptor alpha [AID254256, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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10
[SID103194296]
EC50 0.002Transglutaminase activity in HL-60 cdm-1 cells [AID81281, Type: Literature]
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11
[SID103194296]
EC50 0.002Induction of transglutaminase (TGase) activity in HL-60 cells [AID82828, Type: Literature]
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12
[SID103194296]
EC50 0.0026Effective concentrations against Retinoic acid receptor RXR-beta [AID199801, Type: Literature]
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13
[SID103194296]
Kd 0.003Inhibition of binding to human Retinoic acid receptor RXR DEF domain [AID199343, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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14
[SID103194296]
Kd 0.003Inhibition of binding to human Retinoic acid receptor RXR DEF domain [AID199343, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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15
[SID103194296]
Kd 0.003Inhibition of binding to human Retinoic acid receptor RXR DEF domain [AID199343, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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16
[SID103194296]
EC50 0.003Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR beta [AID166207, Type: Literature]
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17
[SID103194296]
EC50 0.0033Transcriptional activation for RAR beta receptor [AID166209, Type: other]
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18
[SID103194296]
EC50 0.0033Transcriptional activation of Retinoic acid receptor RAR beta [AID199388, Type: Literature]
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19
[SID103194296]
EC50 0.0033Transcriptional activation of Retinoic acid receptor RAR beta [AID198201, Type: Literature]Retinoic acid receptor beta [gi:17380507]
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20
[SID103194296]
EC50 0.0033Transcriptional activation of Retinoic acid receptor RAR beta [AID198201, Type: Literature]Retinoic acid receptor beta [gi:17380507]
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21
[SID103194296]
Ki 0.0038Agonistic activity towards retinoid X receptor-beta [AID199230, Type: Literature]
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22
[SID103194296]
IC50 0.004Binding affinity against retinoic Acid X gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay [AID199380, Type: Literature]
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23
[SID103194296]
EC50 0.004Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR gamma [AID166211, Type: Literature]
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24
[SID103194296]
Kd 0.004Dissociation constant for binding to Retinoid X receptor gamma [AID199953, Type: Literature]Retinoic acid receptor RXR-gamma [gi:1350914]
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25
[SID103194296]
EC50 0.0043Effective concentrations against Retinoic acid receptor RXR-gamma [AID199960, Type: Literature]
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26
[SID103194296]
EC50 0.0045Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gamma [AID167594, Type: Literature]
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27
[SID103194296]
EC50 0.006Transcriptional activation for RAR gamma receptor [AID166213, Type: other]
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28
[SID103194296]
EC50 0.006Transcriptional activation of Retinoic acid receptor RAR gamma [AID199393, Type: Literature]
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29
[SID103194296]
EC50 0.006Effective concentration against Retinoic acid receptor RXR-alpha [AID199632, Type: Literature]
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30
[SID103194296]
EC50 0.006Transcriptional activation of Retinoic acid receptor RAR gamma [AID198713, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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31
[SID103194296]
EC50 0.006Transcriptional activation of Retinoic acid receptor RAR gamma [AID198713, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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32
[SID103194296]
Kd 0.007Dissociation constant for binding to Retinoic acid receptor beta [AID198368, Type: Literature]Retinoic acid receptor beta [gi:133494]
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33
[SID103194296]
IC50 0.007Binding affinity against retinoic Acid beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay [AID199387, Type: Literature]
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34
[SID103194296]
Kd 0.007Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptor [AID198541, Type: other]
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35
[SID103194296]
Kd 0.007Dissociation constant for binding to Retinoic acid receptor alpha [AID197913, Type: Literature]
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36
[SID103194296]
IC50 0.007Binding affinity against retinoic Acid alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay [AID198042, Type: Literature]
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37
[SID103194296]
Ki 0.0074Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR beta [AID199807, Type: Literature]
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38
[SID103194296]
Kd 0.008Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gamma [AID199636, Type: Literature]
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39
[SID103194296]
Kd 0.008Inhibition of [3H]9-cis-RA binding to human Retinoid X receptor RXR alpha [AID199492, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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40
[SID103194296]
Ki 0.008Inhibition of [3H]targretin binding to Retinoid X receptor RXR alpha [AID199495, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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41
[SID103194296]
Kd 0.008Inhibition of [3H]9-cis-RA binding to human Retinoid X receptor RXR alpha [AID199492, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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42
[SID103194296]
Ki 0.008Inhibition of [3H]targretin binding to Retinoid X receptor RXR alpha [AID199495, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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43
[SID103194296]
Kd 0.008Inhibition of [3H]9-cis-RA binding to human Retinoid X receptor RXR alpha [AID199492, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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44
[SID103194296]
Ki 0.008Inhibition of [3H]targretin binding to Retinoid X receptor RXR alpha [AID199495, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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45
[SID103194296]
Ki 0.0084Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR alpha [AID199640, Type: Literature]
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46
[SID103194296]
Ki 0.009Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR beta [AID199784, Type: Literature]Retinoic acid receptor RXR-beta [gi:1350911]
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47
[SID103194296]
Kd 0.009Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor [AID199227, Type: other]
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48
[SID103194296]
Ki 0.0109Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR beta [AID198547, Type: Literature]
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49
[SID103194296]
Kd 0.011Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptor [AID199363, Type: other]
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50
[SID103194296]
Ki 0.011Agonistic activity towards retinoid X receptor-gamma [AID199366, Type: Literature]
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