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alitretinoin (CID 449171) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(172)
 
 
Inactive(264)
 
 
Inconclusive(38)
 
 
Unspecified(58)
 
 
Top Targets:
NR LBD RXR li..(37)
 
 
 
 
NR LBD RAR(32)
 
 
 
 
NR LBD TR(13)
 
 
 
 
NR LBD PPAR(11)
 
 
 
 
NR LBD VDR(11)
 
 
 
BioAssay Types:
Confirmatory(242)
 
 
 
 
Literature(175)
 
 
 
 
Screening(81)
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(223)
 
 
 
 
EC50(65)
 
 
Kd(38)
 
 
 
Ki(16)
 
 
IC50(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 351    Data Row: 532   Total Pages: 27   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103194296]
Ki 0.0005Binding affinity towards cRAR-beta-2 receptor by displacing 1.1 nM 3[H]-9-cis-RA [AID220310, Type: confirmatory]
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2
[SID103194296]
Ki 0.0007Binding affinity towards cRAR-beta-2 receptor by displacing 0.82 nM 3[H]all-trans-RA [AID220308, Type: confirmatory]
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3
[SID103194296]
Kd 0.0008Dissociation constant for Retinoic acid receptor gamma [AID254257, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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4
[SID103194296]
Ki 0.001Agonistic activity towards retinoic acid receptor-gamma [AID198732, Type: Literature]
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5
[SID103194296]
Kd 0.0015Dissociation constant for Retinoid X receptor alpha [AID254256, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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6
[SID103194296]
EC50 0.0015Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha [AID167582, Type: Literature]
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7
[SID103194296]
AC50 0.002Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta [AID198359, Type: Literature]
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8
[SID103194296]
EC50 0.002Transglutaminase activity in HL-60 cdm-1 cells [AID81281, Type: Literature]
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9
[SID103194296]
EC50 0.002Induction of transglutaminase (TGase) activity in HL-60 cells [AID82828, Type: Literature]
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10
[SID103194296]
EC50 0.0026Effective concentrations against Retinoic acid receptor RXR-beta [AID199801, Type: Literature]
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11
[SID103194296]
AC50 0.003Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma [AID198882, Type: Literature]
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12
[SID103194296]
Kd 0.003Inhibition of binding to human Retinoic acid receptor RXR DEF domain [AID199343, Type: Literature]Retinoic acid receptor RXR-alpha [gi:133701]
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13
[SID103194296]
EC50 0.003Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR beta [AID166207, Type: Literature]
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14
[SID103194296]
EC50 0.0033Transcriptional activation of Retinoic acid receptor RAR beta [AID199388, Type: Literature]
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15
[SID103194296]
EC50 0.0033Transcriptional activation for RAR beta receptor [AID166209, Type: confirmatory]
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16
[SID103194296]
EC50 0.0033Transcriptional activation of Retinoic acid receptor RAR beta [AID198201, Type: Literature]Retinoic acid receptor beta [gi:17380507]
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17
[SID103194296]
Ki 0.0038Agonistic activity towards retinoid X receptor-beta [AID199230, Type: Literature]
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18
[SID103194296]
IC50 0.004Binding affinity against retinoic Acid X gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assay [AID199380, Type: Literature]
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19
[SID103194296]
Kd 0.004Dissociation constant for binding to Retinoid X receptor gamma [AID199953, Type: Literature]Retinoic acid receptor RXR-gamma [gi:1350914]
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20
[SID103194296]
EC50 0.004Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR gamma [AID166211, Type: Literature]
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