Bookmark and Share
Diethylstilbestrol (CID 448537) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(180)
 
 
Inactive(1000)
 
 
Inconclusive(210)
 
 
Unspecified(170)
 
 
Top Targets:
NR LBD ER(60)
 
 
 
 
7TM GPCR Srx(40)
 
 
 
 
7TM GPCR Srsx(34)
 
 
 
 
NR LBD PPAR(31)
 
 
 
p450(20)
 
 
 
 
 
BioAssay Types:
Confirmatory(579)
 
 
 
 
 
Screening(490)
 
 
 
 
Literature(167)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(515)
 
 
 
 
 
IC50(173)
 
 
 
 
EC50(18)
 
 
 
 
Ki(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1202    Data Row: 1560   Total Pages: 32   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164490]
EC50 7e-06In vitro agonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells at 10 pM [AID102438, Type: Literature]Estrogen receptor [gi:544257]
View
2
[SID103164490]
EC50 2e-05Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta. [AID70505, Type: Literature]
View
3
[SID103164490]
EC50 6e-05Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha. [AID70186, Type: Literature]
View
4
[SID103164490]
Ki 0.000126Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor [gi:544257]
View
5
[SID103164490]
Ki 0.000126Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor beta [gi:6166154]
View
6
[SID103164490]
Ki 0.000128Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor beta [gi:6166154]
View
7
[SID103164490]
Ki 0.000128Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor [gi:544257]
View
8
[SID103164490]
IC50 0.00033Displacement of radioligand from Estrogen receptor alpha [AID70499, Type: Literature]
View
9
[SID144210844]
Potency-Replicate_1 0.0004qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
10
[SID103164490]
Ki 0.00049In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor alpha [AID70002, Type: Literature]Estrogen receptor [gi:544257]
View
11
[SID103164490]
Ki 0.00063In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor beta [AID70164, Type: Literature]Estrogen receptor beta [gi:6166154]
View
12
[SID103164490]
IC50 0.000915DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
View
13
[SID144209605]
Ratio Potency (uM) 0.00100679qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
14
[SID144210844]
Ratio Potency (uM) 0.00154883qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
15
[SID103164490]
IC50 0.003In vitro inhibition of [3H]17-beta-estradiol binding to human estrogen receptor alpha [AID70008, Type: Literature]Estrogen receptor [gi:544257]
View
16
[SID144209605]
Potency-Replicate_1 0.0039qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
17
[SID103164490]
IC50 0.004In vitro inhibitory concentration against [3H]17-beta-estradiol binding to human estrogen receptor 2 [AID70176, Type: Literature]Estrogen receptor beta [gi:6166154]
View
18
[SID103164490]
EC50 0.009Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor beta. [AID70507, Type: Literature]
View
19
[SID103164490]
EC50 0.012Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor alpha. [AID70191, Type: Literature]
View
20
[SID103164490]
IC50 0.46Inhibition of human aldehyde oxidase [AID547838, Type: Literature]Aldehyde oxidase [gi:215273968]
View
21
[SID103164490]
IC50 0.61Displacement of [3H]-estradiol from human recombinant ERbeta expressed in Sf21 cells after 2 hrs [AID702428, Type: Literature]Estrogen receptor beta [gi:6166154]
View
22
[SID103164490]
EC50 0.63Estrogen-Related Receptor gamma activity in FRET assay [AID246440, Type: Literature]Estrogen-related receptor gamma [gi:50402102]
View
23
[SID103164490]
IC50 0.77Displacement of [3H]-estradiol from human recombinant ERalpha expressed in Sf21 cells after 2 hrs [AID702427, Type: Literature]Estrogen receptor [gi:544257]
View
24
[SID103164490]
IC50 1.071DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
View
25
[SID103164490]
IC50 2.208DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A3 [gi:1351831]
View
26
[SID103164490]
IC50 2.5Cytotoxic effect on 3T3 cells [AID3342, Type: Literature]
View
27
[SID103164490]
IC50 2.718DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: other]Delta-type opioid receptor [gi:311033488]
View
28
[SID103164490]
EC50 2.8Cytotoxicity against Trypanosoma brucei by Alamar blue assay [AID276474, Type: Literature]
View
29
[SID103164490]
IC50 2.856DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A1 [gi:231473]
View
30
[SID103164490]
IC50 2.963DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: other]Arachidonate 15-lipoxygenase [gi:126397]
View
31
[SID103164490]
IC50 3Cytotoxic effect on v-abl transformed murine ANN-1 cells [AID31746, Type: Literature]
View
32
[SID103164490]
IC50 3.14DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
View
33
[SID26747240]
Potency 3.5481qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
View
34
[SID103164490]
IC50 3.67DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
View
35
[SID103164490]
IC50 3.761DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
View
36
[SID103164490]
IC50 4.359DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) [AID625229, Type: other]Thromboxane-A synthase [gi:254763392]
View
37
[SID103164490]
IC50 4.563DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: other]Kappa-type opioid receptor [gi:116242691]
View
38
[SID103164490]
IC50 4.682DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: other]Progesterone receptor [gi:75071465]
View
39
[SID103164490]
IC50 4.735DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
View
40
[SID103164490]
IC50 4.79DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
View
41
[SID103164490]
IC50 5Cytotoxic effect on MCF-7 human breast carcinoma cells [AID103902, Type: Literature]
View
42
[SID103164490]
IC50 5.6DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
View
43
[SID103164490]
IC50 5.778DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
View
44
[SID144209605]
Potency-Replicate_1 6.0634qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
45
[SID103164490]
IC50 7.763DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
View
46
[SID144209605]
Ratio Potency (uM) 8.24226qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
View
47
[SID103164490]
EC50 8.5Cytotoxicity against CHO-K1 cells by Alamar blue assay [AID276475, Type: Literature]
View
48
[SID103164490]
IC50 8.796DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
View
49
[SID103164490]
IC50 9.013DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: other]Adenosine receptor A2a [gi:543740]
View
50
[SID103164490]
IC50 9.553DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) [AID625227, Type: other]Substance-K receptor [gi:229462950]
View