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Diethylstilbestrol (CID 448537) - Compound BioActivity Data
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BioActivity Outcomes:
Active(176)
 
 
Inactive(1011)
 
 
Inconclusive(211)
 
 
Unspecified(603)
 
 
Top Targets:
NR LBD ER(62)
 
 
 
 
7TM GPCR Srx(40)
 
 
 
 
7TM GPCR Srsx(34)
 
 
 
 
NR LBD PPAR(31)
 
 
 
p450(20)
 
 
 
 
 
BioAssay Types:
Confirmatory(695)
 
 
 
 
 
Screening(490)
 
 
 
 
Literature(182)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(516)
 
 
 
 
 
IC50(174)
 
 
 
 
EC50(18)
 
 
 
 
Ki(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1636    Data Row: 2001   Total Pages: 101   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164490]
EC50 7e-06In vitro agonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells at 10 pM [AID102438, Type: Literature]Estrogen receptor [gi:544257]
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2
[SID103164490]
EC50 2e-05Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor beta. [AID70505, Type: Literature]
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3
[SID103164490]
EC50 6e-05Activation of estrogen response element in HeLa cells stably transfected with human Estrogen receptor alpha. [AID70186, Type: Literature]
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4
[SID103164490]
Ki 0.000126Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor [gi:544257]
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5
[SID103164490]
Ki 0.000126Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor beta [gi:6166154]
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6
[SID103164490]
Ki 0.000128Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor beta [gi:6166154]
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7
[SID103164490]
Ki 0.000128Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68909, Type: Literature]Estrogen receptor [gi:544257]
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8
[SID103164490]
IC50 0.00033Displacement of radioligand from Estrogen receptor alpha [AID70499, Type: Literature]
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9
[SID144210844]
Potency-Replicate_1 0.0004qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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10
[SID103164490]
Ki 0.00049In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor alpha [AID70002, Type: Literature]Estrogen receptor [gi:544257]
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11
[SID103164490]
Ki 0.00063In vitro displacement of 0.5 nM [3H]17-beta-estradiol from human Estrogen receptor beta [AID70164, Type: Literature]Estrogen receptor beta [gi:6166154]
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12
[SID103164490]
IC50 0.00077Displacement of [3H]Estradiol from human recombinant estrogen receptor alpha expressed in Sf9 cells after 2 hrs [AID751681, Type: Literature]Estrogen receptor [gi:544257]
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13
[SID103164490]
IC50 0.000915DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: confirmatory]Estrogen receptor [gi:544257]
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14
[SID144209605]
Ratio Potency (uM) 0.00100679qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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15
[SID144210844]
Ratio Potency (uM) 0.00154883qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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16
[SID103164490]
IC50 0.003In vitro inhibition of [3H]17-beta-estradiol binding to human estrogen receptor alpha [AID70008, Type: Literature]Estrogen receptor [gi:544257]
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17
[SID144209605]
Potency-Replicate_1 0.0039qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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18
[SID103164490]
IC50 0.004In vitro inhibitory concentration against [3H]17-beta-estradiol binding to human estrogen receptor 2 [AID70176, Type: Literature]Estrogen receptor beta [gi:6166154]
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19
[SID103164490]
EC50 0.009Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor beta. [AID70507, Type: Literature]
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20
[SID103164490]
EC50 0.012Inhibition of [3H]17-beta-estradiol binding to human recombinant Estrogen receptor alpha. [AID70191, Type: Literature]
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