SMR000131820 (CID 4483669) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(36)
 
 
Inactive(601)
 
 
Inconclusive(20)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(10)
 
 
 
NR LBD ER(8)
 
 
 
7TM GPCR Srsx(8)
 
 
BioAssay Types:
Screening(453)
 
 
 
 
 
Confirmatory(189)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(128)
 
 
 
 
 
IC50(44)
 
 
 
EC50(10)
 
 
AC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 659    Data Row: 659   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14732345]
AC50 1.515Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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2
[SID14732345]
Potency 2.2387qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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3
[SID14732345]
Potency 2.2387qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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4
[SID14732345]
AC50 3.557Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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5
[SID14732345]
IC50 4.35Dose Response Confirmation for Small Molecule Inhibitors of Epstein-Barr Virus [AID1419, Type: confirmatory]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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6
[SID14732345]
IC50 8.20371Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation [AID733, Type: confirmatory]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
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7
[SID14732345]
IC50 8.20371Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation [AID733, Type: confirmatory]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
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8
[SID14732345]
IC50 8.20371Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation [AID733, Type: confirmatory]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
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9
[SID14732345]
IC50 8.43821Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation [AID713, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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10
[SID14732345]
IC50 8.43821Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation [AID713, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View
11
[SID14732345]
IC50 8.43821Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation [AID713, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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12
[SID14732345]
IC50 8.43821Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation [AID713, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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13
[SID14732345]
Potency 8.9125qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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14
[SID14732345]
Potency 8.9125qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
View
15
[SID14732345]
IC50 11.413High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
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16
[SID14732345]
IC50 11.413High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
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17
[SID14732345]
IC50 11.413High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
View
18
[SID14732345]
Potency 11.9955qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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19
[SID14732345]
IC50 12.4TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70 [AID786, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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20
[SID14732345]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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21
[SID14732345]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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22
[SID14732345]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
23
[SID14732345]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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24
[SID14732345]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
25
[SID14732345]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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26
[SID14732345]
Potency 17.7828VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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27
[SID14732345]
IC50 25.2High Throughput Screening Assay for Hsp70 Inhibitors [AID583, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
View
28
[SID14732345]
Potency 28.1838qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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29
[SID14732345]
Potency 28.1838qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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30
[SID14732345]
Potency 28.1838qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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31
[SID14732345]
 Factor XIa Single Well HTS [AID687, Type: screening]coagulation factor XI [gi:180352]
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32
[SID14732345]
 Factor XIa Single Well HTS [AID687, Type: screening]coagulation factor XI [gi:180352]
View
33
[SID14732345]
 uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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34
[SID14732345]
 uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
View
35
[SID14732345]
 CYP2C19 Assay [AID778, Type: screening]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
View
36
[SID14732345]
 CYP2C19 Assay [AID778, Type: screening]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
View
37
[SID14732345]
 uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]CCR6 gene product [Homo sapiens] [gi:37187860]
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38
[SID14732345]
 uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]CCR6 gene product [Homo sapiens] [gi:37187860]
View
39
[SID14732345]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View
40
[SID14732345]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View
41
[SID14732345]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View
42
[SID14732345]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View
43
[SID14732345]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
View
44
[SID14732345]
 CYP2C9 Assay [AID777, Type: screening]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
View
45
[SID14732345]
 CYP2C9 Assay [AID777, Type: screening]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
View
46
[SID14732345]
 CYP2C9 Assay [AID777, Type: screening]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
View
47
[SID14732345]
 uHTS Identification of Diaphorase Inhibitors and Chemcical Oxidizers: Counter Screen for Diaphorase-based Primary Assays [AID1217, Type: screening]Dihydrolipoamide dehydrogenase [Homo sapiens] [gi:17391426]
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48
[SID14732345]
 Colorimetric Assay for Inhibitors for NALP1 [AID2071, Type: screening]NACHT, LRR and PYD domains-containing protein 1 isoform 1 [Homo sapiens] [gi:14719829]
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49
[SID14732345]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492956, Type: screening]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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50
[SID14732345]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet activating factor acetylhydrolase 2 (PAFAH2) [AID492956, Type: screening]platelet-activating factor acetylhydrolase 2, cytoplasmic [Homo sapiens] [gi:4758878]
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