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TO-901317 (CID 447912) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(2)
 
 
Active(197)
 
 
Inactive(350)
 
 
Inconclusive(39)
 
 
Unspecified(127)
 
 
Top Targets:
NR LBD LXR(128)
 
 
 
 
 
7tm 4(17)
 
 
NR LBD PPAR(15)
 
 
 
NR LBD ROR li..(13)
 
 
 
 
 
NR LBD TR(8)
 
 
 
BioAssay Types:
Literature(319)
 
 
 
 
 
Screening(247)
 
 
 
 
Confirmatory(130)
 
 
 
 
 
Summary(2)
 
 
BioActivity Types:
Potency(124)
 
 
 
 
 
EC50(91)
 
 
 
 
IC50(46)
 
 
 
 
Kd(2)
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 592    Data Row: 715   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85257301]
Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]nuclear receptor ROR-alpha isoform a [Homo sapiens] [gi:19743903]
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2
[SID85257301]
Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]nuclear receptor ROR-gamma isoform a [Homo sapiens] [gi:19743909]
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3
[SID103249306]
EC50 0.003Stimulation of [3H]cholesterol efflux in human THP1 foam cells loaded with ac-LDL [AID345492, Type: Literature]
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4
[SID103249306]
EC50 0.003Stimulation of [3H]cholesterol efflux in human THP1 foam cells loaded with ac-LDL [AID452973, Type: Literature]
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5
[SID103249306]
EC50 0.003Stimulation of [3H]cholesterol efflux in human THP1 foam cells loaded with ac-LDL relative to TO901317 [AID452974, Type: Literature]
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6
[SID103249306]
EC50 0.0032Agonist activity at LXRalpha by TR-FRET assay [AID569814, Type: Literature]
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7
[SID103249306]
EC50 0.0047Agonist activity at LXRbeta by TR-FRET assay [AID569815, Type: Literature]
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8
[SID103249306]
EC50 0.008Agonist activity at LXRbeta ligand binding domain by FRET based SRC1 recruitment assay [AID418425, Type: Literature]
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9
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from LXRbeta ligand binding domain [AID478580, Type: Literature]
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10
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha LBD [AID454924, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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11
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha-LBD [AID451978, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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12
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha LBD [AID454631, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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13
[SID103249306]
IC50 0.009Binding affinity at human LXRbeta [AID313446, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
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14
[SID103249306]
IC50 0.009Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate method [AID345471, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
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15
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRbeta ligand binding domain [AID452860, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
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16
[SID103249306]
IC50 0.009Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate method [AID452959, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
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17
[SID103249306]
IC50 0.009Binding affinity to human recombinant LXRbeta ligand binding domain [AID472479, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
18
[SID103249306]
IC50 0.01Displacement of [3H]T-0901317 from human LXR beta receptor [AID273407, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
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19
[SID103249306]
EC50 0.01Activity against LXR alpha transiently transfected in HEK293 cells [AID262339, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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20
[SID103249306]
IC50 0.01Displacement of [3H]T-0901317 from human LXR alpha receptor [AID273406, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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