TO-901317 (CID 447912) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Probe(1)
 
 
Active(144)
 
 
Inactive(292)
 
 
Inconclusive(28)
 
 
Unspecified(88)
 
 
Top Targets:
NR LBD LXR(95)
 
 
 
 
NR LBD PPAR(15)
 
 
 
NR LBD ROR li..(9)
 
 
 
 
7TM GPCR Srx(8)
 
 
NR LBD TR(8)
 
 
 
BioAssay Types:
Literature(228)
 
 
 
 
 
Screening(208)
 
 
 
 
Confirmatory(104)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(102)
 
 
 
 
 
EC50(69)
 
 
 
IC50(35)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 458    Data Row: 553   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85257301]
 Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]RORA gene product [Homo sapiens] [gi:19743903]
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2
[SID85257301]
 Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]RORA gene product [Homo sapiens] [gi:19743903]
View
3
[SID85257301]
 Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]RORA gene product [Homo sapiens] [gi:19743903]
View
4
[SID85257301]
 Summary of probe development efforts to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR). [AID2139, Type: summary]RORA gene product [Homo sapiens] [gi:19743903]
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5
[SID103249306]
EC50 0.003Stimulation of [3H]cholesterol efflux in human THP1 foam cells loaded with ac-LDL [AID345492, Type: Literature]
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6
[SID103249306]
EC50 0.003Stimulation of [3H]cholesterol efflux in human THP1 foam cells loaded with ac-LDL [AID452973, Type: Literature]
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7
[SID103249306]
EC50 0.003Stimulation of [3H]cholesterol efflux in human THP1 foam cells loaded with ac-LDL relative to TO901317 [AID452974, Type: Literature]
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8
[SID103249306]
EC50 0.0032Agonist activity at LXRalpha by TR-FRET assay [AID569814, Type: Literature]
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9
[SID103249306]
EC50 0.0047Agonist activity at LXRbeta by TR-FRET assay [AID569815, Type: Literature]
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10
[SID103249306]
EC50 0.008Agonist activity at LXRbeta ligand binding domain by FRET based SRC1 recruitment assay [AID418425, Type: Literature]
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11
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from LXRbeta ligand binding domain [AID478580, Type: Literature]
View
12
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRbeta ligand binding domain [AID452860, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
13
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRbeta ligand binding domain [AID452860, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
14
[SID103249306]
IC50 0.009Binding affinity to human recombinant LXRbeta ligand binding domain [AID472479, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
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15
[SID103249306]
IC50 0.009Binding affinity to human recombinant LXRbeta ligand binding domain [AID472479, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
16
[SID103249306]
IC50 0.009Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate method [AID452959, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
17
[SID103249306]
IC50 0.009Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate method [AID452959, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
18
[SID103249306]
IC50 0.009Binding affinity at human LXRbeta [AID313446, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
19
[SID103249306]
IC50 0.009Binding affinity at human LXRbeta [AID313446, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
20
[SID103249306]
IC50 0.009Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate method [AID345471, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
21
[SID103249306]
IC50 0.009Displacement of [3H]TO901317 from human recombinant LXRbeta expressed in Escherichia coli by flashplate method [AID345471, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
22
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha LBD [AID454631, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
23
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha LBD [AID454631, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
24
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha LBD [AID454631, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
25
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha-LBD [AID451978, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
26
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha-LBD [AID451978, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
27
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha-LBD [AID451978, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
28
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha LBD [AID454924, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
29
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha LBD [AID454924, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
30
[SID103249306]
IC50 0.009Displacement of [3H]T0901317 from human recombinant LXRalpha LBD [AID454924, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
31
[SID103249306]
IC50 0.01Displacement of [3H]T-0901317 from human LXR alpha receptor [AID273406, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
32
[SID103249306]
IC50 0.01Displacement of [3H]T-0901317 from human LXR alpha receptor [AID273406, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
33
[SID103249306]
IC50 0.01Displacement of [3H]T-0901317 from human LXR alpha receptor [AID273406, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
34
[SID103249306]
EC50 0.01Activity against LXR alpha transiently transfected in HEK293 cells [AID262339, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
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35
[SID103249306]
EC50 0.01Activity against LXR alpha transiently transfected in HEK293 cells [AID262339, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
36
[SID103249306]
EC50 0.01Activity against LXR alpha transiently transfected in HEK293 cells [AID262339, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
37
[SID103249306]
IC50 0.01Displacement of [3H]T-0901317 from human LXR beta receptor [AID273407, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
38
[SID103249306]
IC50 0.01Displacement of [3H]T-0901317 from human LXR beta receptor [AID273407, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
39
[SID103249306]
EC50 0.01Agonist activity at LXRalpha ligand binding domain by FRET based SRC1 recruitment assay [AID418426, Type: Literature]
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40
[SID103249306]
EC50 0.011Activation of LXRbeta co-transfected in COS7 cells with RXRalpha by reporter transactivation assay [AID307304, Type: Literature]
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41
[SID103249306]
EC50 0.011Agonist activity at human LXRbeta receptor transfected in COS7 cells after 16 hrs by reporter transactivation assay [AID299789, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
42
[SID103249306]
EC50 0.011Agonist activity at human LXRbeta receptor transfected in COS7 cells after 16 hrs by reporter transactivation assay [AID299789, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
43
[SID103249306]
IC50 0.013Displacement of [3H]T0901317 from human recombinant LXRbeta LBD [AID454925, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
44
[SID103249306]
IC50 0.013Displacement of [3H]T0901317 from human recombinant LXRbeta LBD [AID454925, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
45
[SID103249306]
IC50 0.013Displacement of [3H]T0901317 from human recombinant LXRbeta LBD [AID454632, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
46
[SID103249306]
IC50 0.013Displacement of [3H]T0901317 from human recombinant LXRbeta LBD [AID454632, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
47
[SID103249306]
IC50 0.013Displacement of [3H]T0901317 from human recombinant LXRbeta-LBD [AID451979, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
48
[SID103249306]
IC50 0.013Displacement of [3H]T0901317 from human recombinant LXRbeta-LBD [AID451979, Type: Literature]Oxysterols receptor LXR-beta [gi:296439251]
View
49
[SID103249306]
IC50 0.013Displacement of [3H]TO901317 from human recombinant LXRalpha expressed in Escherichia coli by flashplate method [AID345472, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View
50
[SID103249306]
IC50 0.013Displacement of [3H]TO901317 from human recombinant LXRalpha expressed in Escherichia coli by flashplate method [AID345472, Type: Literature]Oxysterols receptor LXR-alpha [gi:23503089]
View