Niclosamide (CID 4477) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(234)
 
 
Inactive(632)
 
 
Inconclusive(176)
 
 
Unspecified(81)
 
 
Top Targets:
p450(22)
 
 
 
 
 
7TM GPCR Srx(19)
 
 
 
 
NR LBD TR(10)
 
 
 
HELICc(10)
 
 
 
Binary toxB(10)
 
 
 
BioAssay Types:
Confirmatory(505)
 
 
 
 
 
Screening(306)
 
 
 
 
Literature(147)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(428)
 
 
 
 
 
IC50(71)
 
 
 
 
 
AC50(6)
 
 
 
EC50(4)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 827    Data Row: 1123   Total Pages: 23   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103516894]
IC50 0.00056Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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2
[SID103516894]
IC50 0.00074Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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3
[SID103516894]
IC50 0.00089Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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4
[SID103516894]
IC50 0.00089Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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5
[SID103516894]
IC50 0.00089Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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6
[SID103516894]
IC50 0.001Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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7
[SID103516894]
IC50 0.00148Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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8
[SID56463356]
Potency 0.0398qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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9
[SID90341111]
Potency 0.0651qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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10
[SID11111533]
Potency 0.1qHTS Assay for Identification of Small Molecule Agonists for Thrombopoietin (TPO) Signaling Pathway [AID917, Type: confirmatory]Thrombopoietin [Homo sapiens] [gi:120660324]
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11
[SID103516894]
EC50 0.1Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral relication by ELISA [AID297149, Type: Literature]
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12
[SID90341111]
Potency 0.1qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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13
[SID104171199]
Potency 0.1142Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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14
[SID11111534]
Potency 0.1259qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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15
[SID11111534]
Potency 0.1259qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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16
[SID103516894]
EC50 0.16Antiviral activity against HCV genotype 1b infected in Ava5 cells assessed as inhibition of viral replication after 3 days by blot hybridization analysis [AID642456, Type: Literature]
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17
[SID144203760]
Potency 0.1679qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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18
[SID144203760]
Potency 0.1679qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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19
[SID144203760]
Potency 0.1679qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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20
[SID56463356]
Potency 0.2133qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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21
[SID103516894]
IC50 0.25Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assay [AID581111, Type: other]Signal transducer and activator of transcription 3 [gi:48429227]
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22
[SID103516894]
IC50 0.25Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assay [AID581111, Type: other]Signal transducer and activator of transcription 3 [gi:48429227]
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23
[SID103516894]
IC50 0.25Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assay [AID581111, Type: other]Signal transducer and activator of transcription 3 [gi:48429227]
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24
[SID11111534]
Potency 0.2512qHTS Assay for Anthrax Lethal Toxin Internalization [AID912, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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25
[SID50106712]
Potency 0.3162Validation screen for small molecules that induce DNA re-replication in MCF 10A normal breast cells [AID463097, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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26
[SID56463356]
Potency 0.3381qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen [AID602292, Type: confirmatory]TSHR protein [Homo sapiens] [gi:118341367]
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27
[SID56463356]
Potency 0.3381qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen [AID602292, Type: confirmatory]TSHR protein [Homo sapiens] [gi:118341367]
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28
[SID56463356]
Potency 0.3381qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen [AID602292, Type: confirmatory]TSHR protein [Homo sapiens] [gi:118341367]
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29
[SID56463356]
Potency 0.3663qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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30
[SID56463356]
Potency 0.3663qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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31
[SID56463356]
Potency 0.3663qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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32
[SID56463356]
Potency 0.3663qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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33
[SID103516894]
IC50 0.4Antiproliferative activity against human U87MG cells after 120 hrs by MTT assay [AID503303, Type: Literature]
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34
[SID103516894]
IC50 0.4Antiproliferative activity against human PC3 cells after 120 hrs by MTT assay [AID503299, Type: Literature]
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35
[SID103516894]
IC50 0.4Antiproliferative activity against human A549 cells after 120 hrs by MTT assay [AID503300, Type: Literature]
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36
[SID11111534]
Potency 0.5012qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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37
[SID11111534]
Potency 0.5012qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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38
[SID11111534]
Potency 0.5012qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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39
[SID11111533]
Potency 0.5012qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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40
[SID11111533]
Potency 0.5012qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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41
[SID11111533]
Potency 0.5012qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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42
[SID11111533]
Potency 0.5012qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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43
[SID11111534]
Potency 0.5623qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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44
[SID56463356]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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45
[SID56463356]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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46
[SID56463356]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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47
[SID56463356]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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48
[SID56463356]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
49
[SID56463356]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
50
[SID144203760]
Potency 0.5957qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View