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Niclosamide (CID 4477) - Compound BioActivity Data
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BioActivity Outcomes:
Active(321)
 
 
Inactive(780)
 
 
Inconclusive(268)
 
 
Unspecified(84)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
 
 
p450(24)
 
 
 
 
NR LBD PPAR(21)
 
 
 
7TM GPCR Srsx(18)
 
 
NR LBD ER(17)
 
 
 
 
BioAssay Types:
Confirmatory(700)
 
 
 
 
 
Screening(358)
 
 
 
 
Literature(178)
 
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(655)
 
 
 
 
 
IC50(80)
 
 
 
 
 
AC50(6)
 
 
 
EC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1000    Data Row: 1453   Total Pages: 30   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103516894]
IC50 0.00056Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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2
[SID103516894]
IC50 0.00074Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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3
[SID103516894]
IC50 0.00089Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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4
[SID103516894]
IC50 0.00089Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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5
[SID103516894]
IC50 0.00089Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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6
[SID103516894]
IC50 0.001Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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7
[SID103516894]
IC50 0.00148Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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8
[SID144211066]
Potency-Replicate_1 0.0097qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID144203760]
Potency-Replicate_1 0.0266qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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10
[SID144211066]
Potency-Replicate_1 0.0347qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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11
[SID144203760]
Ratio Potency (uM) 0.0348017qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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12
[SID56463356]
Potency 0.0398qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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13
[SID90341111]
Potency 0.0651qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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14
[SID144203760]
Potency-Replicate_1 0.075qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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15
[SID144203760]
Potency-Replicate_1 0.0944qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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16
[SID144211066]
Potency-Replicate_1 0.0969qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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17
[SID103516894]
EC50 0.1Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral relication by ELISA [AID297149, Type: Literature]
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18
[SID90341111]
Potency 0.1qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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19
[SID11111533]
Potency 0.1qHTS Assay for Identification of Small Molecule Agonists for Thrombopoietin (TPO) Signaling Pathway [AID917, Type: confirmatory]Thrombopoietin [Homo sapiens] [gi:120660324]
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20
[SID104171199]
Potency 0.1142Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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21
[SID144211066]
Potency-Replicate_1 0.123qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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22
[SID11111534]
Potency 0.1259qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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23
[SID103516894]
EC50 0.16Antiviral activity against HCV genotype 1b infected in Ava5 cells assessed as inhibition of viral replication after 3 days by blot hybridization analysis [AID642456, Type: Literature]
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24
[SID144203760]
Potency 0.1679qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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25
[SID144203760]
AhR Potency (uM) 0.181246qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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26
[SID144211066]
AhR Potency (uM) 0.193312qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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27
[SID144203760]
Potency-Replicate_1 0.2113qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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28
[SID56463356]
Potency 0.2133qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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29
[SID103516894]
IC50 0.25Inhibition of STAT3 in human HeLa cells after 24 hrs by luciferase reporter gene assay [AID581111, Type: other]Signal transducer and activator of transcription 3 [gi:48429227]
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30
[SID11111534]
Potency 0.2512qHTS Assay for Anthrax Lethal Toxin Internalization [AID912, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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31
[SID170465184]
Potency-Replicate_1 0.2592qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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32
[SID144211066]
Potency-Replicate_1 0.2754qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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33
[SID144203760]
Potency-Replicate_1 0.2985qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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34
[SID144211066]
Potency-Replicate_1 0.309qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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35
[SID50106712]
Potency 0.3162Validation screen for small molecules that induce DNA re-replication in MCF 10A normal breast cells [AID463097, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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36
[SID144203760]
Potency-Replicate_1 0.3349qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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37
[SID56463356]
Potency 0.3381qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen [AID602292, Type: confirmatory]TSHR protein [Homo sapiens] [gi:118341367]
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38
[SID56463356]
Potency 0.3663qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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39
[SID56463356]
Potency 0.3663qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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40
[SID103516894]
IC50 0.4Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells after 8 hrs by TOPflash reporter assay [AID741323, Type: Literature]
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41
[SID103516894]
IC50 0.4Antiproliferative activity against human U87MG cells after 120 hrs by MTT assay [AID503303, Type: Literature]
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42
[SID103516894]
IC50 0.4Antiproliferative activity against human PC3 cells after 120 hrs by MTT assay [AID503299, Type: Literature]
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43
[SID103516894]
IC50 0.4Antiproliferative activity against human A549 cells after 120 hrs by MTT assay [AID503300, Type: Literature]
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44
[SID144203760]
Potency-Replicate_1 0.4216qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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45
[SID144211066]
Potency-Replicate_1 0.4328qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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46
[SID144211066]
Potency-Replicate_1 0.4364qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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47
[SID170465184]
Potency-Replicate_1 0.461qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
View
48
[SID144203760]
Ratio Potency (uM) 0.473079qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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49
[SID144203760]
Potency-Replicate_1 0.4731qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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50
[SID144203760]
Potency-Replicate_1 0.4731qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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