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PD 173955 (CID 447077) - Compound BioActivity Data
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BioActivity Outcomes:
Active(218)
 
 
Inactive(7)
 
 
Unspecified(256)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
PTKc Abl(17)
 
 
STKc AGC(17)
 
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Literature(474)
 
 
 
Confirmatory(7)
 
 
BioActivity Types:
Kd(442)
 
 
 
IC50(26)
 
 
 
Potency(7)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 475    Data Row: 481   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103499403]
Ki 0.0002Inhibition of recombinant c-Abl after 30 mins [AID501985, Type: Literature]
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2
[SID103499403]
Kd 0.00052Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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3
[SID103499403]
Kd 0.00055Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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4
[SID103499403]
Kd 0.00058Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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5
[SID103499403]
Kd 0.00063Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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6
[SID103499403]
Kd 0.00067Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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7
[SID103499403]
Kd 0.00069Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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8
[SID103499403]
Kd 0.00071Binding constant for SRC kinase domain [AID625016, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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9
[SID103499403]
Kd 0.00088Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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10
[SID103499403]
Kd 0.00093Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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11
[SID103499403]
Kd 0.0011Binding constant for LCK kinase domain [AID625013, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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12
[SID103499403]
Kd 0.0013Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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13
[SID103499403]
Kd 0.0014Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
14
[SID103499403]
Kd 0.0014Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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15
[SID103499403]
Kd 0.0015Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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16
[SID103499403]
Kd 0.0015Binding constant for BLK kinase domain [AID624841, Type: Literature]Tyrosine-protein kinase Blk [gi:158936749]
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17
[SID103499403]
Kd 0.0016Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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18
[SID103499403]
Kd 0.0018Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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19
[SID103499403]
IC50 0.002Inhibition of Bcr-Abl fusion protein [AID271012, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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20
[SID103499403]
IC50 0.002Inhibition of Bcr-Abl fusion protein [AID271012, Type: Literature]Breakpoint cluster region protein [gi:143811366]
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21
[SID103499403]
Kd 0.002Binding constant for EPHB6 kinase domain [AID624957, Type: Literature]Ephrin type-B receptor 6 [gi:294862532]
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22
[SID103499403]
Kd 0.0022Binding constant for LYN kinase domain [AID624862, Type: Literature]Tyrosine-protein kinase Lyn [gi:125480]
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23
[SID103499403]
Kd 0.0023Binding constant for YES kinase domain [AID625018, Type: Literature]Tyrosine-protein kinase Yes [gi:125870]
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24
[SID103499403]
Kd 0.0024Binding constant for FGR kinase domain [AID625011, Type: Literature]Tyrosine-protein kinase Fgr [gi:125358]
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25
[SID103499403]
Kd 0.0024Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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26
[SID103499403]
Kd 0.0025Binding constant for ABL1(F317L)-phosphorylated kinase domain [AID624982, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
27
[SID103499403]
Kd 0.0032Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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28
[SID103499403]
Kd 0.0033Binding constant for HCK kinase domain [AID624857, Type: Literature]Tyrosine-protein kinase HCK [gi:20141296]
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29
[SID103499403]
Kd 0.0037Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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30
[SID103499403]
Kd 0.0038Binding constant for EPHA2 kinase domain [AID624951, Type: Literature]Ephrin type-A receptor 2 [gi:229462861]
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31
[SID103499403]
Kd 0.004Binding constant for BMPR1B kinase domain [AID624825, Type: Literature]Bone morphogenetic protein receptor type-1B [gi:6226778]
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32
[SID103499403]
Kd 0.0041Binding constant for FRK kinase domain [AID624855, Type: Literature]Tyrosine-protein kinase FRK [gi:1169745]
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33
[SID103499403]
Kd 0.0044Binding constant for EPHB1 kinase domain [AID624954, Type: Literature]Ephrin type-B receptor 1 [gi:1706663]
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34
[SID103499403]
Kd 0.0044Binding constant for BRAF(V600E) kinase domain [AID624947, Type: Literature]Serine/threonine-protein kinase B-raf [gi:50403720]
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35
[SID103499403]
Kd 0.0049Binding constant for FYN kinase domain [AID624727, Type: Literature]Tyrosine-protein kinase Fyn [gi:125370]
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36
[SID103499403]
IC50 0.005Inhibition of Lck [AID435999, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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37
[SID103499403]
Kd 0.005Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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38
[SID103499403]
Kd 0.0053Binding constant for ABL1(F317I)-phosphorylated kinase domain [AID624980, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
39
[SID103499403]
Kd 0.0056Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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40
[SID103499403]
Kd 0.0057Binding constant for BRAF kinase domain [AID624946, Type: Literature]Serine/threonine-protein kinase B-raf [gi:50403720]
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41
[SID103499403]
Kd 0.0059Binding constant for EPHA8 kinase domain [AID625120, Type: Literature]Ephrin type-A receptor 8 [gi:19857975]
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42
[SID103499403]
Kd 0.0065Binding constant for SIK kinase domain [AID624733, Type: Literature]Serine/threonine-protein kinase SIK1 [gi:59803093]
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43
[SID103499403]
Kd 0.0065Binding constant for EPHA1 kinase domain [AID625008, Type: Literature]Ephrin type-A receptor 1 [gi:317373566]
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44
[SID103499403]
Kd 0.0076Binding constant for EPHA3 kinase domain [AID625009, Type: Literature]Ephrin type-A receptor 3 [gi:116241351]
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45
[SID103499403]
Kd 0.0082Binding constant for GAK kinase domain [AID625012, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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46
[SID103499403]
Kd 0.0083Binding constant for EPHA4 kinase domain [AID624952, Type: Literature]Ephrin type-A receptor 4 [gi:1711371]
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47
[SID103499403]
Kd 0.0091Binding constant for ACVR2B kinase domain [AID624820, Type: Literature]Activin receptor type-2B [gi:97535735]
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48
[SID103499403]
Kd 0.01Binding constant for ACVR2A kinase domain [AID624838, Type: Literature]Activin receptor type-2A [gi:114722]
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49
[SID103499403]
Kd 0.012Binding constant for EPHB4 kinase domain [AID624956, Type: Literature]Ephrin type-B receptor 4 [gi:19860819]
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50
[SID103499403]
Kd 0.012Binding constant for DDR2 kinase domain [AID624777, Type: Literature]Discoidin domain-containing receptor 2 [gi:215273969]
View