Mycophenolic Acid (CID 446541) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(241)
 
 
Inactive(763)
 
 
Inconclusive(84)
 
 
Unspecified(255)
 
 
Top Targets:
p450(31)
 
 
 
 
 
7TM GPCR Srx(21)
 
 
 
IMPDH(19)
 
 
 
7TM GPCR Srsx(14)
 
 
 
Tubulin-bindi..(13)
 
 
 
BioAssay Types:
Confirmatory(499)
 
 
 
 
 
Screening(315)
 
 
 
 
Literature(282)
 
 
 
 
 
BioActivity Types:
Potency(335)
 
 
 
 
 
IC50(198)
 
 
 
 
EC50(26)
 
 
 
 
Ki(14)
 
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 995    Data Row: 1343   Total Pages: 27   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103226686]
Ki 0.006Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II isoform); Range is 6-10 nM [AID92748, Type: Literature]
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2
[SID103226686]
Ki 0.007Inhibition of human IMPDH2 by Spectrophotometer [AID580126, Type: Literature]Inosine-5'-monophosphate dehydrogenase 2 [gi:124419]
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3
[SID103226686]
Ki 0.007Inhibition of human IMPDH type 2 [AID303352, Type: Literature]Inosine-5'-monophosphate dehydrogenase 2 [gi:124419]
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4
[SID103226686]
Ki 0.01Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II) [AID92749, Type: Literature]
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5
[SID103226686]
Ki 0.01Inhibition of human IMPDH 2 [AID304372, Type: Literature]Inosine-5'-monophosphate dehydrogenase 2 [gi:124419]
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6
[SID103226686]
Ki 0.01Inhibition of human IMPDH2 [AID348819, Type: Literature]Inosine-5'-monophosphate dehydrogenase 2 [gi:124419]
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7
[SID103226686]
IC50 0.011Inhibition of human IMPDH2 [AID267726, Type: Literature]Inosine-5'-monophosphate dehydrogenase 2 [gi:124419]
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8
[SID103226686]
IC50 0.012Inhibition of human IMPDH2 expressed in Escherichia coli strain BL21(DE3) after 60 mins [AID538354, Type: Literature]Inosine-5'-monophosphate dehydrogenase 2 [gi:124419]
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9
[SID103226686]
IC50 0.014Inhibition of human inosine-5'-monophosphate dehydrogenase 2 [AID92622, Type: other]
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10
[SID103226686]
IC50 0.014Inhibition of human inosine monophosphate dehydrogenase IMPDH II [AID92624, Type: Literature]
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11
[SID103226686]
IC50 0.014Inhibitory activity against inosine monophosphate dehydrogenase IMPDH II [AID92740, Type: Literature]
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12
[SID103226686]
IC50 0.015Inhibition of human Inosine-5'-monophosphate dehydrogenase 2 [AID92741, Type: Literature]
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13
[SID103226686]
IC50 0.015Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme [AID92742, Type: Literature]
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14
[SID103226686]
IC50 0.015Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determined [AID92743, Type: Literature]
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15
[SID103226686]
IC50 0.015In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2. [AID92745, Type: Literature]
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16
[SID103226686]
IC50 0.015Inhibition of Inosine Monophosphate Dehydrogenase II (IMPDH II) [AID91402, Type: Literature]Inosine-5'-monophosphate dehydrogenase 2 [gi:124419]
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17
[SID103226686]
IC50 0.016Inhibition of human IMPDH2 [AID292040, Type: Literature]Inosine-5'-monophosphate dehydrogenase 2 [gi:124419]
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18
[SID103226686]
IC50 0.019Inhibition of human IMPDH1 expressed in Escherichia coli strain BL21(DE3) after 60 mins [AID538353, Type: Literature]Inosine-5'-monophosphate dehydrogenase 1 [gi:25014074]
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19
[SID103226686]
IC50 0.02In vitro inhibition of inosine Inosine-5'-monophosphate dehydrogenase [AID92486, Type: Literature]Inosine-5'-monophosphate dehydrogenase 1 [gi:25014074]
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20
[SID103226686]
IC50 0.02In vitro inhibition of human lymphocyte proliferation in response to pokeweed mitogen(PWM) was determined [AID90470, Type: Literature]
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21
[SID103226686]
IC50 0.0248Compound was tested for inhibition of human recombinant type II Inosine Monophosphate Dehydrogenase at pH 8.0 [AID92617, Type: Literature]
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22
[SID103226686]
IC50 0.0251Compound was tested for inhibition of human recombinant type II Inosine Monophosphate Dehydrogenase at pH 7.4 [AID92616, Type: Literature]
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23
[SID103226686]
IC50 0.032Inhibition of human IMPDH1 [AID267725, Type: Literature]Inosine-5'-monophosphate dehydrogenase 1 [gi:25014074]
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24
[SID47193743]
Potency 0.0326qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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25
[SID103226686]
Ki 0.033Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I isoform); Range is 33-37 nM [AID92607, Type: Literature]
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26
[SID103226686]
Ki 0.033Inhibition of human IMPDH type 1 [AID303351, Type: Literature]Inosine-5'-monophosphate dehydrogenase 1 [gi:25014074]
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27
[SID103226686]
Ki 0.033Inhibition of human IMPDH1 by Spectrophotometry [AID580128, Type: Literature]Inosine-5'-monophosphate dehydrogenase 1 [gi:25014074]
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28
[SID103226686]
Ki 0.04Inhibition of human IMPDH1 [AID348818, Type: Literature]Inosine-5'-monophosphate dehydrogenase 1 [gi:25014074]
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29
[SID103226686]
Ki 0.04Inhibition of human IMPDH 1 [AID304371, Type: Literature]Inosine-5'-monophosphate dehydrogenase 1 [gi:25014074]
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30
[SID103226686]
Ki 0.04Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I) [AID92608, Type: Literature]
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31
[SID103226686]
EC50 0.04Inhibition of Rluc-FL-WNV replicon in Vero cells [AID261586, Type: Literature]
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32
[SID103226686]
EC50 0.04Inhibition of West Nile virus VLP replicon in BHK21 cell line [AID261589, Type: Literature]
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33
[SID85148364]
IC50 0.05A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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34
[SID103226686]
IC50 0.055Inhibitory activity against inosine monophosphate dehydrogenase IMPDH type I [AID92606, Type: Literature]
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35
[SID103226686]
IC50 0.058Inhibition of human Lymphocyte proliferation. The IC50 values were determined by interpolation using cubic spline determination. [AID89839, Type: Literature]
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36
[SID103226686]
IC50 0.06In vitro inhibition of human lymphocyte proliferation in response to phytohemagglutinin (PHA) was determined [AID90469, Type: Literature]
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37
[SID103226686]
IC50 0.06In vitro inhibition of human lymphocyte proliferation in response to staphylococcus protein A(SPA) was determined [AID90471, Type: Literature]
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38
[SID103226686]
IC50 0.075Antiproliferative activity against human MOLT4 cells after 48 hrs by MTT assay [AID668550, Type: Literature]
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39
[SID103226686]
EC50 0.08Inhibition of West Nile viral Rluc-Neo-Rep in Vero cells [AID261590, Type: Literature]
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40
[SID103226686]
IC50 0.08Inhibitory activity against growth of human erythroleukemia K652 cells [AID95166, Type: Literature]
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41
[SID103226686]
IC50 0.0992Antiproliferative activity against HUVEC as measured by [3H]thymidine incorporation [AID264222, Type: Literature]
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42
[SID144204161]
Potency 0.1137qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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43
[SID144204161]
Potency 0.1137qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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44
[SID47193743]
EC50 0.116Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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45
[SID103226686]
IC50 0.128Antiproliferative activity against Jurkat T cells as measured by [3H]thymidine incorporation [AID264223, Type: Literature]
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46
[SID103226686]
IC50 0.13Inhibition of T cell proliferation in PBMC cells [AID292041, Type: Literature]
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47
[SID124882524]
Potency 0.1496qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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48
[SID47193743]
Potency 0.1836qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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49
[SID103226686]
IC50 0.19Cytotoxicity against human K562 cells after 72 hrs by trypan blue exclusion assay [AID538356, Type: Literature]
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50
[SID103226686]
IC50 0.193Antiproliferative activity against human Jurkat cells after 48 hrs by MTT assay [AID668549, Type: Literature]
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