ferulic acid (CID 445858) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(23)
 
 
Inactive(497)
 
 
Inconclusive(8)
 
 
Unspecified(190)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(15)
 
 
 
p450(10)
 
 
 
alpha CA I II..(5)
 
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(292)
 
 
 
Confirmatory(185)
 
 
 
 
Literature(88)
 
 
 
 
 
BioActivity Types:
IC50(146)
 
 
 
 
 
Potency(111)
 
 
 
 
Ki(13)
 
 
EC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 712    Data Row: 718   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103207410]
Ki 0.00077Displacement of [125I]TZDM from human beta amyloid fibril 1-42 [AID308323, Type: Literature]
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2
[SID103207410]
IC50 0.2Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhage incubated with compound for 10 mins measured after 24 hrs [AID592088, Type: Literature]
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3
[SID103207410]
Ki 2.4Inhibition of human CA2 by stopped-flow CO2 hydration assay [AID462271, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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4
[SID103207410]
Ki 2.89Inhibition of human CA1 by stopped-flow CO2 hydration assay [AID462270, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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5
[SID103207410]
IC50 3.975DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: other]Arachidonate 15-lipoxygenase [gi:126397]
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6
[SID103207410]
Ki 7.04Inhibition of human CA5A by stopped-flow CO2 hydration assay [AID462274, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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7
[SID103207410]
Ki 7.41Inhibition of human CA7 by stopped-flow CO2 hydration assay [AID462277, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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8
[SID103207410]
Ki 8.45Inhibition of human CA6 by stopped-flow CO2 hydration assay [AID462276, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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9
[SID103207410]
Ki 9.43Inhibition of human CA14 by stopped-flow CO2 hydration assay [AID462281, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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10
[SID103207410]
Ki 9.78Inhibition of human CA12 by stopped-flow CO2 hydration assay [AID462279, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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11
[SID103207410]
Ki 9.87Inhibition of human CA9 by stopped-flow CO2 hydration assay [AID462278, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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12
[SID103207410]
Ki 10.5Inhibition of human CA5B by stopped-flow CO2 hydration assay [AID462275, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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13
[SID103207410]
Ki 10.8Inhibition of human CA4 by stopped-flow CO2 hydration assay [AID462273, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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14
[SID103207410]
Ki 11.1Inhibition of human CA3 by stopped-flow CO2 hydration assay [AID462272, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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15
[SID103207410]
Ki 12.2Inhibition of mouse CA13 by stopped-flow CO2 hydration assay [AID462280, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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16
[SID47193700]
 HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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17
[SID103207410]
 Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins [AID475504, Type: Literature]
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18
[SID103207410]
 Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins [AID475505, Type: Literature]
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19
[SID103207410]
 Antioxidant activity assessed as DPPH scavenging activity [AID399080, Type: Literature]
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20
[SID103207410]
 Antihyperglycemic activity in po dosed diabetic KK-Ay mouse model [AID592241, Type: Literature]
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21
[SID103207410]
 Hypoglycemic activity in rat assessed as decrease in plasma glucose at 5 mg/kg, iv [AID592242, Type: Literature]
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22
[SID103207410]
 Hypoglycemic activity in rat assessed as increase in insulin concentration at 5 mg/kg, iv [AID592243, Type: Literature]
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23
[SID57264356]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening]
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24
[SID103207410]
IC50 68Cytotoxicity against human OE21 cells after 72 hrs by MTT assay [AID607594, Type: Literature]
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25
[SID103207410]
IC50 95Cytotoxicity against human LoVo cells after 72 hrs by MTT assay [AID607598, Type: Literature]
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26
[SID103207410]
IC50 100Cytotoxicity against human U373 cells after 72 hrs by MTT assay [AID607593, Type: Literature]
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27
[SID103207410]
IC50 100Cytotoxicity against human A549 cells after 72 hrs by MTT assay [AID607595, Type: Literature]
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28
[SID103207410]
IC50 100Cytotoxicity against human PC3 cells after 72 hrs by MTT assay [AID607596, Type: Literature]
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29
[SID103207410]
IC50 100Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay [AID607597, Type: Literature]
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30
[SID103207410]
IC50 100Inhibition of HIV1 integrase by ELISA [AID371216, Type: Literature]
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31
[SID103207410]
IC50 100Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's method [AID635414, Type: Literature]Acetylcholinesterase [gi:14916521]
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32
[SID103207410]
IC50 111.6Antioxidant activity assessed as residual DPPH radical scavenging activity after 45 mins by spectrophotometrically [AID568834, Type: Literature]
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33
[SID103207410]
EC50 250Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry [AID590194, Type: Literature]
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34
[SID103207410]
IC50 350Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry [AID590195, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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35
[SID103207410]
IC50 1000Cytotoxicity against human K562 cells after 5 days by XTT assay [AID312292, Type: Literature]
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36
[SID103207410]
IC50 2000Inhibition of hyaluronidase [AID477408, Type: Literature]
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37
[SID103207410]
 Cytotoxicity against human PANC1 cells in nutrient-deprived condition assessed as preferential cell death after 24 hrs by trypan blue dye exclusion method [AID477928, Type: Literature]
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38
[SID103207410]
 Antioxidant activity assessed as formazan formation induced absorbance changes at 25 ppm at 570 nm at 37 degC for 6 hrs by MTT assay [AID492140, Type: Literature]
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39
[SID103207410]
 Redox potential at pH 7.3 by differential pulse and cyclic voltametry [AID499282, Type: Literature]
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40
[SID103207410]
 Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation in liposomes measured as Trolox equivalent antioxidant capacity [AID499283, Type: Literature]
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41
[SID103207410]
 Antiinflammatory activity in CD1 mouse assessed as inhibition of croton oil-induced ear oedema at 0.3 umol/cm^2 after 6 hrs [AID309363, Type: Literature]
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42
[SID103207410]
 Cell viability in TPA-induced superoxide (O2-) generation in human promyelocytic leukemia HL-60 cells, at 100 uM concentration [AID82003, Type: Literature]
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43
[SID103207410]
 Inhibitory activity against TPA-induced superoxide (O2-) generation in human promyelocytic leukemia HL-60 cells, at 100 uM concentration [AID82327, Type: Literature]
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44
[SID103207410]
 Inhibition of HDAC in human Hela cells nuclear extracts assessed as residual activity at 500 uM by fluorimetric assay [AID447578, Type: Literature]
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45
[SID103207410]
 Antioxidant activity assessed as trolox equivalents of ABTS radical scavenging activity by TEAC assay [AID568835, Type: Literature]
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46
[SID103207410]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 30 uM after 72 hrs [AID462333, Type: Literature]
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47
[SID103207410]
 Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 30 uM in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay [AID462342, Type: Literature]
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48
[SID103207410]
 Hypoglycemic activity in rat L6 myotubes assessed as increase in 2-deoxyglucose transport at 25 uM relative to control [AID592244, Type: Literature]
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49
[SID103207410]
 Antioxidant activity assessed as trolox equivalents by ORAC-fluorescence assay [AID331670, Type: Literature]
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50
[SID103207410]
 Inhibition of bovine thymocytes protein tyrosine kinase assessed as angiotensin 1 phosphorylation [AID336952, Type: other]
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