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GNF-PF-1958 (CID 44582409) - Compound BioActivity Data
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BioActivity Outcomes:
Active(16)
 
 
Unspecified(38)
 
 
Top Targets:
Esterase lipa..(2)
 
 
BioAssay Types:
Literature(50)
 
 
 
BioActivity Types:
EC50(3)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 54    Data Row: 54   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103631848]
EC50 0.0012Binding affinity to HIF-1 5'-CGTG-3' DNA sequence in human U251 cells assessed as inhibition of HRE-mediated reporter activation [AID714174, Type: Literature]
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2
[SID103631848]
IC50 0.003Cytotoxicity against human HCT116 cells [AID417514, Type: Literature]
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3
[SID103631848]
MIC 0.01Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 29212 by CLIS method [AID417512, Type: Literature]
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4
[SID103631848]
MIC 0.01Antimicrobial activity against methicillin-resistant Enterococcus faecalis ATCC 35556 by CLIS method [AID417513, Type: Literature]
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5
[SID103631848]
MIC 0.03Antimicrobial activity against methicillin-resistant Staphylococcus aureus L32 clinical isolate by CLIS method [AID417510, Type: Literature]
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6
[SID103631848]
MIC 0.03Antimicrobial activity against methicillin-resistant Staphylococcus aureus L44 clinical isolate by CLIS method [AID417511, Type: Literature]
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7
[SID103631848]
EC50 0.0737NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: other]
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8
[SID103631848]
IC50 0.5Cytotoxicity in human leukaemic CCRF-CEM cells. [AID43704, Type: Literature]
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9
[SID103631848]
EC50 0.524NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: other]
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10
[SID103631848]
Inhibition of methicillin-susceptible Staphylococcus aureus ATCC 29212 biofilm formation assessed as visible growth after 24 hrs [AID417529, Type: Literature]
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11
[SID103631848]
Inhibition of methicillin-susceptible Staphylococcus aureus ATCC 29212 biofilm formation assessed as concentration required to eradicate growth after 24 hrs [AID417530, Type: Literature]
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12
[SID103631848]
Inhibition of Enterococcus faecalis ATCC 35556 biofilm formation assessed as visible growth after 24 hrs [AID417531, Type: Literature]
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13
[SID103631848]
Inhibition of Enterococcus faecalis ATCC 35556 biofilm formation assessed as concentration required to eradicate growth after 24 hrs [AID417532, Type: Literature]
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14
[SID103631848]
Binding affinity to calf thymus DNA at 20 uM after 20 mins by UV spectrophotometer analysis [AID552124, Type: Literature]
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15
[SID103631848]
Inhibition of Staphylococcus aureus ATCC 29212 biofilm formation at MIC [AID417523, Type: Literature]
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16
[SID103631848]
Inhibition of Enterococcus faecalis ATCC 35556 biofilm formation at MIC [AID417524, Type: Literature]
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17
[SID103631848]
CC50 10NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) [AID449705, Type: other]
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18
[SID103631848]
NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. [AID449706, Type: other]
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19
[SID103631848]
Binding affinity to calf thymus DNA assessed as change on melting temperature (Rvb = 78 degC) [AID552126, Type: Literature]
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20
[SID103631848]
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method [AID697852, Type: Literature]Acetylcholinesterase [gi:14916521]
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21
[SID103631848]
Inhibition of horse BChE at 2 mg/ml by Ellman's method [AID697853, Type: Literature]Cholinesterase [gi:21362409]
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22
[SID103631848]
Inhibition of methicillin-resistant Staphylococcus aureus L32 clinical isolate biofilm formation assessed as visible growth after 24 hrs [AID417525, Type: Literature]
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23
[SID103631848]
Inhibition of methicillin-resistant Staphylococcus aureus L32 clinical isolate biofilm formation assessed as concentration required to eradicate growth after 24 hrs [AID417526, Type: Literature]
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24
[SID103631848]
Inhibition of methicillin-resistant Staphylococcus aureus L44 clinical isolate biofilm formation assessed as visible growth after 24 hrs [AID417527, Type: Literature]
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25
[SID103631848]
Inhibition of methicillin-resistant Staphylococcus aureus L44 clinical isolate biofilm formation assessed as concentration required to eradicate growth after 24 hrs [AID417528, Type: Literature]
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26
[SID103631848]
Antimicrobial activity against methicillin-resistant Staphylococcus aureus L32 clinical isolate assessed as reduction in bacterial load at 2 X MIC over 24 hrs by time-kill assay [AID417515, Type: Literature]
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27
[SID103631848]
Antimicrobial activity against methicillin-resistant Staphylococcus aureus L44 clinical isolate assessed as reduction in bacterial load at 2 X MIC over 24 hrs by time-kill assay [AID417516, Type: Literature]
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28
[SID103631848]
Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29212 assessed as reduction in bacterial load at 2 X MIC over 24 hrs by time-kill assay [AID417517, Type: Literature]
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29
[SID103631848]
Antimicrobial activity against Enterococcus faecalis ATCC 35556 assessed as reduction in bacterial load at 2 X MIC over 24 hrs by time-kill assay [AID417518, Type: Literature]
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30
[SID103631848]
Antimicrobial activity against methicillin-resistant Staphylococcus aureus L32 clinical isolate assessed as reduction in bacterial load at 4 fold MIC over 24 hrs by time-kill assay [AID417519, Type: Literature]
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31
[SID103631848]
Antimicrobial activity against methicillin-resistant Staphylococcus aureus L44 clinical isolate assessed as reduction in bacterial load at 4 fold MIC over 24 hrs by time-kill assay [AID417520, Type: Literature]
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32
[SID103631848]
Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29212 assessed as reduction in bacterial load at 4 fold MIC over 24 hrs by time-kill assay [AID417521, Type: Literature]
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33
[SID103631848]
Antimicrobial activity against Enterococcus faecalis ATCC 35556 assessed as reduction in bacterial load at 4 fold MIC over 24 hrs by time-kill assay [AID417522, Type: Literature]
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34
[SID103631848]
Inhibitory activity against growth of HT-29 colon tumor cell line was determined by MTT assay [AID83754, Type: Literature]
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35
[SID103631848]
Percentage of apoptotic HT-29 cells after 24 H treatment with 10 ug/mL concentration of compound [AID83937, Type: Literature]
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36
[SID103631848]
In vitro cytotoxicity against P388 tumor cell lines. [AID152925, Type: Literature]
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37
[SID103631848]
In vivo antitumor activity was determined against P388 tumor cell lines in mice at dose of 0.03125 mg/kg administered intraperitoneally. [AID152928, Type: Literature]
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38
[SID103631848]
In vivo antitumor activity was determined against P388 tumor cell lines in mice at dose of 0.0625 mg/kg administered intraperitoneally. [AID152929, Type: Literature]
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39
[SID103631848]
In vivo antitumor activity was determined against P388 tumor cell lines in mice at dose of 0.125 mg/kg administered intraperitoneally. [AID152930, Type: Literature]
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40
[SID103631848]
In vivo antitumor activity was determined against P388 tumor cell lines in mice at dose of 0.25 mg/kg administered intraperitoneally. [AID153061, Type: Literature]
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41
[SID103631848]
In vivo antitumor activity was determined against P388 tumor cell lines in mice at dose of 1 mg/kg administered intraperitoneally. [AID153064, Type: Literature]
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42
[SID103631848]
Inhibitory activity against growth of PANC-1 tumor cell line was determined by MTT assay [AID154609, Type: Literature]
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43
[SID103631848]
In vitro cytotoxicity against SNU16 tumor cell lines. [AID200832, Type: Literature]
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44
[SID103631848]
Cytotoxicity against mouse P388 cells assessed as concentration required for 50% inhibition [AID318601, Type: Literature]
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45
[SID103631848]
Antimicrobial activity against Bacillus anthracis [AID399575, Type: Literature]
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46
[SID103631848]
Antiplasmodial activity against Plasmodium falciparum [AID399576, Type: Literature]
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47
[SID103631848]
Inhibitory activity against growth of B16 mouse myeloma cell line was determined by MTT assay [AID39137, Type: Literature]
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48
[SID103631848]
In vitro cytotoxicity against B16 tumor cell lines. [AID40736, Type: Literature]
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49
[SID103631848]
In vivo antitumor activity was determined against B16 tumor cell lines in mice at dose of 0.03125 mg/kg administered intraperitoneally. [AID40740, Type: Literature]
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50
[SID103631848]
In vivo antitumor activity was determined against B16 tumor cell lines in mice at dose of 0.0625 mg/kg administered intraperitoneally. (p<0.05) [AID40741, Type: Literature]
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