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GNF-PF-1958 (CID 44582409) - Compound BioActivity Data
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BioActivity Outcomes:
Active(16)
 
 
Unspecified(38)
 
 
Top Targets:
Esterase lipa..(2)
 
 
BioAssay Types:
Literature(54)
 
 
 
BioActivity Types:
EC50(3)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 54    Data Row: 54   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103631848]
EC50 0.0012Binding affinity to HIF-1 5'-CGTG-3' DNA sequence in human U251 cells assessed as inhibition of HRE-mediated reporter activation [AID714174, Type: Literature]
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2
[SID103631848]
IC50 0.003Cytotoxicity against human HCT116 cells [AID417514, Type: Literature]
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3
[SID103631848]
EC50 0.0737NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: Literature]
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4
[SID103631848]
IC50 0.5Cytotoxicity in human leukemic CCRF-CEM cells. [AID43704, Type: Literature]
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5
[SID103631848]
EC50 0.524NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: Literature]
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6
[SID103631848]
Binding affinity to calf thymus DNA at 20 uM after 20 mins by UV spectrophotometer analysis [AID552124, Type: Literature]
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7
[SID103631848]
Inhibition of methicillin-susceptible Staphylococcus aureus ATCC 29212 biofilm formation assessed as concentration required to eradicate growth after 24 hrs [AID417530, Type: Literature]
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8
[SID103631848]
Inhibition of Enterococcus faecalis ATCC 35556 biofilm formation assessed as visible growth after 24 hrs [AID417531, Type: Literature]
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9
[SID103631848]
Inhibition of Enterococcus faecalis ATCC 35556 biofilm formation assessed as concentration required to eradicate growth after 24 hrs [AID417532, Type: Literature]
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10
[SID103631848]
Inhibition of Enterococcus faecalis ATCC 35556 biofilm formation at MIC [AID417524, Type: Literature]
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11
[SID103631848]
Inhibition of methicillin-susceptible Staphylococcus aureus ATCC 29212 biofilm formation assessed as visible growth after 24 hrs [AID417529, Type: Literature]
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12
[SID103631848]
Inhibition of Staphylococcus aureus ATCC 29212 biofilm formation at MIC [AID417523, Type: Literature]
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13
[SID103631848]
Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 29212 by CLIS method [AID417512, Type: Literature]
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14
[SID103631848]
Antimicrobial activity against methicillin-resistant Enterococcus faecalis ATCC 35556 by CLIS method [AID417513, Type: Literature]
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15
[SID103631848]
Antimicrobial activity against methicillin-resistant Staphylococcus aureus L32 clinical isolate by CLIS method [AID417510, Type: Literature]
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16
[SID103631848]
Antimicrobial activity against methicillin-resistant Staphylococcus aureus L44 clinical isolate by CLIS method [AID417511, Type: Literature]
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17
[SID103631848]
CC50 10NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) [AID449705, Type: Literature]
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18
[SID103631848]
Binding affinity to calf thymus DNA assessed as change on melting temperature (Rvb = 78 degC) [AID552126, Type: Literature]
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19
[SID103631848]
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method [AID697852, Type: Literature]Acetylcholinesterase [gi:14916521]
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20
[SID103631848]
Inhibition of horse BChE at 2 mg/ml by Ellman's method [AID697853, Type: Literature]Cholinesterase [gi:21362409]
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