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methyllycaconitine (CID 44575473) - Compound BioActivity Data
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BioActivity Outcomes:
Active(40)
 
 
Inactive(5)
 
 
Inconclusive(12)
 
 
Unspecified(28)
 
 
Top Targets:
Neur chan LBD(36)
 
 
 
 
Neur chan mem..(1)
 
 
BioAssay Types:
Literature(85)
 
 
 
 
 
BioActivity Types:
Ki(40)
 
 
 
 
IC50(19)
 
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 72    Data Row: 85   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103617273]
Ki 0.00015Displacement of [3H]IMD from nAChR in Myzus persicae 4106A (green peach aphid) membrane after 70 min [AID1112902, Type: Literature]
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2
[SID103617273]
Ki 0.00037Displacement of [3H]-methyl-SFX from nAChR in Myzus persicae 4106A (green peach aphid) membrane after 70 min [AID1112903, Type: Literature]
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3
[SID103617273]
Ki 0.0006Binding affinity against alpha7 nAChR (nicotinic acetylcholine receptor) using [3H]-MLA as a radioligand relative to alpha4-beta2 [AID146929, Type: Literature]
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4
[SID103617273]
Ki 0.0008Binding affinity against alpha-7 nAChR (nicotinic acetylcholine receptor) using [125I]-alpha-BGT as a radioligand relative to alpha4-beta2 [AID146928, Type: Literature]
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5
[SID103617273]
Ki 0.0011Displacement of [3H]methyllycaconitine from human alpha-7 in tsA201 cells coexpressed with 5HT3A receptor [AID297964, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
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6
[SID103617273]
Ki 0.0016Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR/5HT3A in tsA201 cells [AID297972, Type: Literature]
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7
[SID103617273]
Ki 0.0017Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR Y195F mutant/5HT3A receptor in tsA201 cells [AID297986, Type: Literature]
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8
[SID103617273]
Ki 0.0019Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR Y168A mutant/5HT3A receptor in tsA201 cells [AID297983, Type: Literature]
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9
[SID103617273]
Ki 0.0023Inhibitory constant against [3H]methyllycaconitine binding towards Nicotinic acetylcholine receptor alpha-7 of rat brain hippocampus [AID239458, Type: Literature]
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10
[SID103617273]
Ki 0.0023Binding affinity nicotinic acetylcholine receptor alpha-7 was evaluated by its ability to inhibit [3H]methyllycaconitine ([3H]-MLA) binding to rat brain membranes [AID146934, Type: Literature]
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11
[SID103617273]
Ki 0.0023Affinity for Nicotinic acetylcholine receptor alpha4-beta2 tested by analogue-induced inhibition of [3H]NIC binding to rat striatal membranes [AID146315, Type: Literature]
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12
[SID103617273]
Ki 0.0025Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR S148A mutant /5HT3A receptor in tsA201 cells [AID297979, Type: Literature]
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13
[SID103617273]
Ki 0.0032Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR N107A mutant/5HT3A receptor in tsA201 cells [AID297977, Type: Literature]
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14
[SID103617273]
Ki 0.0035Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR R79A mutant/5HT3A receptor R79A mutant in tsA201 cells [AID297975, Type: Literature]
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15
[SID103617273]
Ki 0.0035Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR S150A mutant/5HT3A receptor in tsA201 cells [AID297982, Type: Literature]
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16
[SID103617273]
Ki 0.0039Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR K145A mutant/5HT3A receptor in tsA201 cells [AID297978, Type: Literature]
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17
[SID103617273]
Ki 0.004Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in rat brain membrane [AID354881, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:146345356]
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18
[SID103617273]
Ki 0.0043Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR K145R mutant /5HT3A receptor in tsA201 cells [AID297989, Type: Literature]
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19
[SID103617273]
Ki 0.0045Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR W55Y mutant/5HT3A receptor in tsA201 cells [AID297974, Type: Literature]
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20
[SID103617273]
Ki 0.0048Binding affinity towards alpha-7 neuronal nicotinic acetylcholine receptor (nAChRs) measured by using the inhibition of [3H]-MLA binding to whole brain membrane [AID220453, Type: Literature]
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