Bookmark and Share
methyllycaconitine (CID 44575473) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(38)
 
 
Inactive(5)
 
 
Inconclusive(12)
 
 
Unspecified(28)
 
 
Top Targets:
Neur chan LBD(36)
 
 
 
 
Neur chan mem..(1)
 
 
BioAssay Types:
Literature(83)
 
 
 
 
 
BioActivity Types:
Ki(38)
 
 
 
 
IC50(19)
 
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 70    Data Row: 83   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103617273]
Ki 0.0006Binding affinity against alpha7 nAChR (nicotinic acetylcholine receptor) using [3H]-MLA as a radioligand relative to alpha4-beta2 [AID146929, Type: Literature]
View
2
[SID103617273]
Ki 0.0008Binding affinity against alpha-7 nAChR (nicotinic acetylcholine receptor) using [125I]-alpha-BGT as a radioligand relative to alpha4-beta2 [AID146928, Type: Literature]
View
3
[SID103617273]
Ki 0.0011Displacement of [3H]methyllycaconitine from human alpha-7 in tsA201 cells coexpressed with 5HT3A receptor [AID297964, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
4
[SID103617273]
Ki 0.0016Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR/5HT3A in tsA201 cells [AID297972, Type: Literature]
View
5
[SID103617273]
Ki 0.0017Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR Y195F mutant/5HT3A receptor in tsA201 cells [AID297986, Type: Literature]
View
6
[SID103617273]
Ki 0.0019Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR Y168A mutant/5HT3A receptor in tsA201 cells [AID297983, Type: Literature]
View
7
[SID103617273]
Ki 0.0023Affinity for Nicotinic acetylcholine receptor alpha4-beta2 tested by analogue-induced inhibition of [3H]NIC binding to rat striatal membranes [AID146315, Type: Literature]
View
8
[SID103617273]
Ki 0.0023Inhibitory constant against [3H]methyllycaconitine binding towards Nicotinic acetylcholine receptor alpha-7 of rat brain hippocampus [AID239458, Type: Literature]
View
9
[SID103617273]
Ki 0.0023Binding affinity nicotinic acetylcholine receptor alpha-7 was evaluated by its ability to inhibit [3H]methyllycaconitine ([3H]-MLA) binding to rat brain membranes [AID146934, Type: Literature]
View
10
[SID103617273]
Ki 0.0025Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR S148A mutant /5HT3A receptor in tsA201 cells [AID297979, Type: Literature]
View
11
[SID103617273]
Ki 0.0032Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR N107A mutant/5HT3A receptor in tsA201 cells [AID297977, Type: Literature]
View
12
[SID103617273]
Ki 0.0035Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR R79A mutant/5HT3A receptor R79A mutant in tsA201 cells [AID297975, Type: Literature]
View
13
[SID103617273]
Ki 0.0035Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR S150A mutant/5HT3A receptor in tsA201 cells [AID297982, Type: Literature]
View
14
[SID103617273]
Ki 0.0039Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR K145A mutant/5HT3A receptor in tsA201 cells [AID297978, Type: Literature]
View
15
[SID103617273]
Ki 0.004Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in rat brain membrane [AID354881, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:146345356]
View
16
[SID103617273]
Ki 0.0043Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR K145R mutant /5HT3A receptor in tsA201 cells [AID297989, Type: Literature]
View
17
[SID103617273]
Ki 0.0045Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR W55Y mutant/5HT3A receptor in tsA201 cells [AID297974, Type: Literature]
View
18
[SID103617273]
Ki 0.0048Binding affinity towards alpha-7 neuronal nicotonic acetylcholine receptor (nAChRs) measured by using the inhibition of [3H]-MLA binding to whole brain membrane [AID220453, Type: Literature]
View
19
[SID103617273]
Ki 0.0055Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR D197A mutant/5HT3A receptor in tsA201 cells [AID297987, Type: Literature]
View
20
[SID103617273]
Ki 0.0061Displacement of [3H]methyllycaconitine from alpha7 nAChR in tsA201 cells co-expressed with Ric3 [AID297965, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
21
[SID103617273]
Ki 0.0073Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitine [AID254538, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
22
[SID103617273]
IC50 0.0076Binding affinity of Norditerpenoid Alkaloids at rat neuronal alpha7-type nicotinic acetylcholine receptor [AID146924, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:146345356]
View
23
[SID103617273]
IC50 0.0083Antagonist activity at human alpha-7 nAChR in tsA201 cells coexpressed with Ric3 by FMP assay [AID297967, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
24
[SID103617273]
IC50 0.0083Antagonist activity at human alpha7nAChR co-expressed with human Ric3 in tsA201 cells by FMP assay [AID297990, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
25
[SID103617273]
Ki 0.013Displacement of [3H]methyllycaconitine from chimeric alpha7nAChR Y195A mutant/5HT3A receptor in tsA201 cells [AID297985, Type: Literature]
View
26
[SID103617273]
Ki 0.024Displacement of [3H]methyllycaconitine from chimeric alpha-7nAChR W55A mutant /5HT3A receptor in tsA201 cells [AID297973, Type: Literature]
View
27
[SID103617273]
IC50 0.089Antagonist activity at human alpha7 nAChR W149Y mutant co-expressed with human Ric3 in tsA201 cells by FMP assay [AID297993, Type: Literature]
View
28
[SID103617273]
IC50 0.32Antagonist activity at human alpha-7 nAChR Y195A mutant coexpressed with human Ric3 in tsA201 cells by FMP assay [AID297995, Type: Literature]
View
29
[SID103617273]
Ki 0.4Displacement of [3H]cytisine from alpha4beta2 nAChR in rat brain membrane [AID354880, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
30
[SID103617273]
Ki 1.3Binding affinity towards alpha3-beta4 neuronal nicotinic acetylcholine receptor [AID145979, Type: Literature]
View
31
[SID103617273]
Ki 1.46Binding affinity towards alpha4-beta2 measured by using the inhibition of [3H]NIC binding to rat striatal membrane [AID220126, Type: Literature]
View
32
[SID103617273]
Ki 1.56Affinity for alpha-7 neuronal nicotinic acetylcholine receptor subtype determined by inhibition of [3H]-MLA binding to rat brain membranes [AID146926, Type: Literature]
View
33
[SID103617273]
Ki 1.56Binding affinity for nicotinic acetylcholine receptor alpha4-beta2 was evaluated by its ability to inhibit [3H]NIC binding to rat brain membranes [AID146468, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
34
[SID103617273]
Ki 1.56Binding affinity for nicotinic acetylcholine receptor alpha4-beta2 was evaluated by its ability to inhibit [3H]NIC binding to rat brain membranes [AID146468, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
35
[SID103617273]
IC50 1.8Antagonist activity at human alpha-7 nAChR Y188A mutant coexpressed with human Ric3 in tsA201 cells by FMP assay [AID297994, Type: Literature]
View
36
[SID103617273]
IC50 2.6Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretion [AID42810, Type: Literature]
View
37
[SID103617273]
IC50 10Antagonist activity at human alpha7nAChR Y93A mutant co-expressed with human Ric3 in tsA201 cells by FMP assay [AID297991, Type: Literature]
View
38
[SID103617273]
EC50 29.5121Reduction of acetylcholine-induced muscle contraction in frog abdominal straight muscle [AID510178, Type: Literature]
View
39
[SID103617273]
IC50 1Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta2 [AID241632, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:113105]
View
40
[SID103617273]
IC50 1Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7 [AID241410, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
41
[SID103617273]
IC50 1Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4 [AID241631, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:2506129]
View
42
[SID103617273]
IC50 1Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta4 [AID241633, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:2506129]
View
43
[SID103617273]
Ki 1Binding affinity against alpha-7 nAChR (nicotinic acetylcholine receptor) using [3H]epibatidine as a radioligand relative to alpha4-beta2 [AID146930, Type: Literature]
View
44
[SID103617273]
IC50 1Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta4 [AID241633, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:254763435]
View
45
[SID103617273]
IC50 1Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta2 [AID241632, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:254763435]
View
46
[SID103617273]
IC50 1Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4 [AID241631, Type: Literature]Neuronal acetylcholine receptor subunit alpha-2 [gi:308153405]
View
47
[SID103617273]
Ki 10Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2; Not significant [AID238996, Type: Literature]
View
48
[SID103617273]
Blockage of fast-decaying currents evoked by ACh or choline at Nicotinic acetylcholine receptor alpha-7 at 10 nM [AID147085, Type: Literature]
View
49
[SID103617273]
Antagonist activity was determined by inhibition of neuronal nicotine acetylcholine receptor (nAChR)-stimulated catecholamine release in cultured bovine adrenal chromaffin cells [AID145342, Type: Literature]
View
50
[SID103617273]
Ki or IC50 concentration against Nicotinic acetylcholine receptor alpha4-beta4 [AID244297, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:2506129]
View