farnesyl pyrophosphate (CID 445713) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(16)
 
 
Inconclusive(2)
 
 
Unspecified(2)
 
 
Top Targets:
PPTA(3)
 
 
 
Trans IPPS HT(2)
 
 
Trans IPPS HH(1)
 
 
BioAssay Types:
Literature(17)
 
 
 
BioActivity Types:
Kd(1)
 
 
Ki(1)
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 20    Data Row: 20   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103261936]
Km 0.04Michaelis-Menten constant against Farnesyltransferase [AID239737, Type: Literature]
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2
[SID103261936]
Kd 0.075Inhibition of yeast Farnesyl transferase [AID72942, Type: other]Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [gi:266880]
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3
[SID103261936]
Km 0.107Binding affinity constant against mammalian protein Farnesyltransferase [AID71338, Type: Literature]
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4
[SID103261936]
Km 0.71Activity at human GGPPS [AID326144, Type: Literature]Geranylgeranyl pyrophosphate synthase [gi:6831549]
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5
[SID103261936]
Km 2.3Activity of human full length squalene synthase expressed in baculovirus [AID326563, Type: Literature]Squalene synthase [gi:585126]
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6
[SID103261936]
Km 2.3Activity of Trypanosoma cruzi microsomal or mitochondrial squalene synthase [AID326560, Type: Literature]
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7
[SID103261936]
Km 2.5Activity of Saccharomyces cerevisiae C-terminal truncated squalene synthase [AID326564, Type: Literature]
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8
[SID103261936]
Ki 2.6Inhibitory activity against microsomal Squalene synthase [AID204983, Type: Literature]
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9
[SID103261936]
Km 2.8Activity of human double-truncated squalene synthase [AID326558, Type: Literature]
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10
[SID103261936]
Km 2.8Activity of Trypanosoma cruzi glycosomal squalene synthase [AID326559, Type: Literature]
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11
[SID103261936]
Km 2.8Activity of Leishmania mexicana microsomal or mitochondrial squalene synthase [AID326562, Type: Literature]
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12
[SID103261936]
Km 3.2Activity of Leishmania mexicana glycosomal squalene synthase [AID326561, Type: Literature]
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13
[SID103261936]
Km 3.2Activity at Saccharomyces cerevisiae GGPPS [AID326143, Type: Literature]Geranylgeranyl pyrophosphate synthase [gi:74676512]
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14
[SID103261936]
Km 5.25Activity of Trypanosoma cruzi truncated squalene synthase 24/36 [AID326557, Type: Literature]
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15
[SID103261936]
Km 12.7Competitive inhibitory activity against microsomal Squalene synthase [AID204988, Type: Literature]
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16
[SID103261936]
Km 27Dissociation constant against yeast farnesyltransferase [AID73582, Type: Literature]Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [gi:266880]
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17
[SID103261936]
 Catalytic constant against Farnesyltransferase [AID242845, Type: Literature]
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18
[SID103261936]
 Ratio of Kcat to Km for farnesyltransferase [AID242941, Type: Literature]
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19
[SID103261936]
 The compound was tested in vitro for inhibitory activity against squalene synthase using rat liver microsomal assay; No data [AID204975, Type: other]
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20
[SID103261936]
 Inhibition of yeast Farnesyl transferase; No data [AID72941, Type: other]Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [gi:266880]
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