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CHEMBL474124 (CID 44564345) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(13)
 
 
Top Targets:
DUF3371(6)
 
 
BioAssay Types:
Confirmatory(10)
 
 
Literature(3)
 
 
BioActivity Types:
AC50(10)
 
 
IC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 13    Data Row: 13   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103592698]
IC50 2.2Inhibition of Hsp90 in human SKBR3 cells assessed as down-regulation of Her2 protein by ELISA [AID347502, Type: Literature]
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2
[SID103592698]
IC50 2.2Antiproliferative activity against ERalpha positive human MCF7 cells after 72 hrs by MTS/PMS assay [AID347503, Type: Literature]
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3
[SID103592698]
IC50 2.7Antiproliferative activity against ERalpha negative/Her2 over expressing human SKBR3 cells after 72 hrs by MTS/PMS assay [AID347638, Type: Literature]
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4
[SID134970465]
AC50_uM 4.13MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624290, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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5
[SID134970465]
AC50_uM 4.84MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set5 [AID624363, Type: confirmatory]
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6
[SID134970465]
AC50_uM 5.44MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set4 [AID624316, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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7
[SID134970465]
AC50_uM 6.89MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624259, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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8
[SID134970465]
AC50_uM 8.33MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624489, Type: confirmatory]
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9
[SID134970465]
AC50_uM 11.69MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624289, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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10
[SID134970465]
AC50_uM 11.95MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_DryPowder_Activity_Set2 [AID624299, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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11
[SID134970465]
AC50_uM 13.35MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624324, Type: confirmatory]
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12
[SID134970465]
AC50_uM 13.4MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity_Set4 [AID624364, Type: confirmatory]
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13
[SID134970465]
AC50_uM 13.85MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624315, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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