Oleic Acid (CID 445639) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(37)
 
 
Inactive(827)
 
 
Inconclusive(31)
 
 
Unspecified(46)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
KCNQ channel(13)
 
 
 
NR LBD PPAR(10)
 
 
 
 
NR LBD TR(10)
 
 
 
NR LBD ROR li..(7)
 
 
 
BioAssay Types:
Confirmatory(413)
 
 
 
 
 
Screening(345)
 
 
 
 
Literature(151)
 
 
 
 
 
BioActivity Types:
Potency(271)
 
 
 
 
 
IC50(52)
 
 
 
 
 
EC50(8)
 
 
 
Ki(6)
 
 
 
Kd(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 795    Data Row: 941   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167698]
Ki 0.18Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP high binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay [AID407366, Type: Literature]Fatty acid-binding protein, liver [gi:119810]
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2
[SID103167698]
Ki 0.185Displacement of 1,8-ANS from aFABP by fluorescence based-assay [AID307907, Type: Literature]
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3
[SID103167698]
Kd 0.2Binding affinity to L-FABP high binding affinity site by titration calorimetry method [AID407370, Type: Literature]
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4
[SID103167698]
Ki 0.248Displacement of 1,8-ANS from eFABP by fluorescence based-assay [AID307909, Type: Literature]
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5
[SID103167698]
Kd 0.9Binding affinity to L-FABP low binding affinity site by titration calorimetry method [AID407371, Type: Literature]
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6
[SID103167698]
Ki 2.9Displacement of 1-anilinonaphthalene-8-sulphonic acid from rat recombinant L-FABP low binding affinity site expressed in Escherichia coli BL21 by competitive fluorescence displacement assay [AID407369, Type: Literature]Fatty acid-binding protein, liver [gi:119810]
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7
[SID103167698]
GI50 10Growth inhibitory activity against human cancer cell line in the NCI?s anticancer drug screening program [AID247402, Type: Literature]
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8
[SID26732603]
EC50 10.41Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents [AID2121, Type: confirmatory]putative potassium channel subunit [Homo sapiens] [gi:487738]
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9
[SID26732603]
EC50 10.41Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents [AID2121, Type: confirmatory]putative potassium channel subunit [Homo sapiens] [gi:487738]
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10
[SID26732603]
EC50 10.41Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents [AID2121, Type: confirmatory]putative potassium channel subunit [Homo sapiens] [gi:487738]
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11
[SID26732603]
EC50 10.41Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents [AID2121, Type: confirmatory]putative potassium channel subunit [Homo sapiens] [gi:487738]
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12
[SID26732603]
EC50 10.41Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents [AID2121, Type: confirmatory]putative potassium channel subunit [Homo sapiens] [gi:487738]
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13
[SID17388831]
Potency 19.9526qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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14
[SID103167698]
IC50 21Inhibition of amidolytic activity of human recombinant soluble tissue factor/human factor 7a preincubated with factor 7a for 90 mins [AID402798, Type: Literature]
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15
[SID103167698]
Ki 22Binding affinity to soybean LO1 [AID455092, Type: Literature]Seed linoleate 13S-lipoxygenase-1 [gi:126398]
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16
[SID103167698]
IC50 26.1Displacement of 8-anilino-1-naphthalene-sulfonic acid from human His-FABP4 expressed in Escherichia coli BL21 (DE3) cells after 3 mins [AID483947, Type: Literature]Fatty acid-binding protein, adipocyte [gi:119781]
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17
[SID26752911]
Potency 29.8554A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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18
[SID103167698]
IC50 30Inhibition of amidolytic activity of human recombinant soluble tissue factor/human factor 7a preincubated with factor 7a for 15 mins [AID402797, Type: Literature]
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19
[SID103167698]
IC50 31Inhibition of DNA topoisomerase 1 [AID361445, Type: Literature]
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20
[SID26752911]
Potency 31.6228qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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21
[SID26752911]
Potency 31.6228qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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22
[SID103167698]
IC50 32.7Inhibition of aromatase in human placental microsomes by radiometric method [AID376617, Type: Literature]Cytochrome P450 19A1 [gi:117293]
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23
[SID17388831]
Potency 35.4813qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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24
[SID17388831]
Potency 35.4813qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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25
[SID144204637]
Potency 35.4813qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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26
[SID144204637]
Potency 35.4813qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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27
[SID26752911]
Potency 35.4813Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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28
[SID26732603]
Potency 89.1251qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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29
[SID46392022]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Human Serum Albumin Complexed With Cis-9-Octadecenoic Acid (Oleic Acid) [gi:18158774]
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30
[SID46391972]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Toward Changing Specificity: Adipocyte Lipid Binding Protein Mutant, Oleic Acid Bound Form [gi:33356927]
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31
[SID26732603]
 uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]FASN gene product [Homo sapiens] [gi:41872631]
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32
[SID26732603]
 uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]FASN gene product [Homo sapiens] [gi:41872631]
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33
[SID26732603]
 uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]FASN gene product [Homo sapiens] [gi:41872631]
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34
[SID26732603]
 uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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35
[SID26732603]
 uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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36
[SID46393429]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Schistosoma Mansoni Fatty Acid Binding Protein In Complex With Oleic Acid [gi:55670477]
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37
[SID46392136]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, 1.4 Angstroms Structural Studies On Human Muscle Fatty Acid Binding Protein: Binding Intera [gi:157831354]
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38
[SID103167698]
 Binding affinity to enterotoxigenic Escherichia coli 12566 heat-labile enterotoxin assessed as inhibition of heat-labile enterotoxin binding to ganglioside GM1 receptor [AID423137, Type: Literature]
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39
[SID103167698]
IC50 Inhibition of FAAH [AID346660, Type: Literature]
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40
[SID17388831]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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41
[SID17388831]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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42
[SID26732603]
 Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
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43
[SID26732603]
 Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
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44
[SID26732603]
 Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
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45
[SID26732603]
 Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
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46
[SID26732603]
 Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
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47
[SID26732603]
 Counter screen assay of the parental CHO cells for identification of compounds that potentiate KCNQ1 potassium channels [AID493006, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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48
[SID26732603]
 Validation assay for identification of compounds that potentiate KCNQ1 potassium channels [AID493007, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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49
[SID26732603]
 Specificity screen against KCNQ1 for compounds that potentiate KCNQ2 potassium channels [AID2283, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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50
[SID26732603]
 uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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