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thiolactomycin (CID 445629) - Compound BioActivity Data
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BioActivity Outcomes:
Active(26)
 
 
Inactive(74)
 
 
Inconclusive(12)
 
 
Unspecified(52)
 
 
Top Targets:
KAS I II(6)
 
 
HELICc(5)
 
 
 
PKS(4)
 
 
Bromo ALL-1(3)
 
 
KAS III(3)
 
 
 
BioAssay Types:
Confirmatory(77)
 
 
 
 
 
Literature(71)
 
 
 
 
 
Screening(13)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(76)
 
 
 
 
 
IC50(19)
 
 
 
 
Kd(6)
 
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 153    Data Row: 164   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50106765]
Potency 1qHTS Validation Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID1705, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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2
[SID103551068]
IC50 1.9Inhibition of Escherichia coli FabB [AID697056, Type: Literature]
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3
[SID50106765]
Potency 1.9953Confirmation qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2572, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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4
[SID50106765]
Potency 3.1623qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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5
[SID103551068]
IC50 4Inhibitory activity against KasA from Mycobacterium tuberculosis H37Rv [AID259392, Type: Literature]3-oxoacyl-[acyl-carrier-protein] synthase 3 [gi:618797914]
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6
[SID103551068]
IC50 6Inhibitory activity against KasB from Mycobacterium tuberculosis H37Rv [AID259391, Type: Literature]3-oxoacyl-[acyl-carrier-protein] synthase 2 [gi:617133540]
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7
[SID50106765]
Potency 8.9125qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2353, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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8
[SID50106765]
Potency 8.9125qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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9
[SID50106765]
Potency 11.2202Counterscreen for RECQ1 Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2711, Type: confirmatory]
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10
[SID50106765]
Potency 11.2202Counterscreen for BLMA Inhibitors: ADP Fluorescence Polarization Displacement Assay [AID2712, Type: confirmatory]
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11
[SID103551068]
IC50 12Inhibitory activity against FabB from Escherichia coli ANSI [AID259388, Type: Literature]
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12
[SID50106765]
Potency 14.1254qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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13
[SID53813060]
Kd 25Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Beta-Ketoacyl-Acp Synthase I (Kas) From E. Coli With Bound Inhibitor Thiolactomycin [gi:163931073]
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14
[SID53813060]
Kd 25Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Beta-Ketoacyl-Acp Synthase I (Kas) From E. Coli With Bound Inhibitor Thiolactomycin [gi:163931073]
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15
[SID50106765]
Potency 25.1189qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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16
[SID46391893]
Kd 26Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, The Structure Of Beta-Ketoacyl-[acyl Carrier Protein] Synthase I In Complex With Thiolactomycin, Implications For Drug Design [gi:10120827]
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17
[SID46391893]
Kd 26Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, The Structure Of Beta-Ketoacyl-[acyl Carrier Protein] Synthase I In Complex With Thiolactomycin, Implications For Drug Design [gi:10120827]
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18
[SID50106765]
Potency 39.8107Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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19
[SID103551068]
IC50 49Antimicrobial activity against Plasmodium falciparum [AID496819, Type: Literature]
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20
[SID50106765]
Potency 50.1187qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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