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MONO TFA SALT (CID 44552613) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(23)
 
 
Inactive(178)
 
 
Inconclusive(8)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
7TM GPCR Srx(7)
 
 
MH2 SMAD 2 3(4)
 
 
 
Alpha TIF(4)
 
 
 
RasGEF(4)
 
 
BioAssay Types:
Screening(162)
 
 
 
 
Confirmatory(42)
 
 
 
 
Literature(3)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(38)
 
 
 
 
AC50(2)
 
 
 
EC50(2)
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 200    Data Row: 211   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID87235992]
Summary of probe development efforts to identify inhibitors of Wee1 degradation [AID1807, Type: summary]WEE1 homolog (S. pombe) [Homo sapiens] [gi:47123300]
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2
[SID99495575]
AbsAC50_uM 1.79Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_Dose_CherryPick_Activity [AID652241, Type: confirmatory]Vif [Human immunodeficiency virus 1] [gi:9629361]
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3
[SID99495575]
Potency 2.2387qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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4
[SID99495575]
IC50 2.971Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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5
[SID99495575]
Potency 4.1095qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
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6
[SID99495575]
Potency 5.8048qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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7
[SID87235992]
Wee1 Degradation (EC50) 6.188Late stage results from the probe development effort to identify inhibitors of Wee1 degradation. [AID2088_1, Type: screening]WEE1 homolog (S. pombe) [Homo sapiens] [gi:47123300]
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8
[SID99495575]
IC50 8.229Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3):Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID624395, Type: confirmatory]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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9
[SID99495575]
Potency 25.929qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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10
[SID99495575]
Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity [AID602346, Type: screening]Vif [Human immunodeficiency virus 1] [gi:9629361]
View
11
[SID99495575]
Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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12
[SID99495575]
Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify nonselective inhibitors of the Steroidogenic acute regulatory protein (StAR) promoter or luminescence assay artifacts [AID651611, Type: screening]
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13
[SID99495575]
Counterscreen for activators of the GAA850 frataxin promoter: luminescence-based cell-based high throughput screening assay to identify activators of the GAA30 frataxin promoter [AID588350, Type: screening] [geneid:2395]
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14
[SID99495575]
Luminescence-based cell-based high throughput confirmation assay for activators of the GAA850 frataxin (FXN) promoter [AID588351, Type: screening] [geneid:2395]
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15
[SID99495575]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening] [geneid:2395]
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16
[SID99495575]
Luminescence-based cell-based high throughput confirmation assay for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID651613, Type: screening]nuclear receptor subfamily 5 group A member 2 isoform 2 [Homo sapiens] [gi:4504343]
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17
[SID99495575]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID602396, Type: screening]nuclear receptor subfamily 5 group A member 2 isoform 2 [Homo sapiens] [gi:4504343]
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18
[SID99495575]
TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC) [AID720596, Type: screening]major prion protein preproprotein [Homo sapiens] [gi:4506113]
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19
[SID87235992]
Late stage results from the probe development effort to identify inhibitors of Wee1 degradation. [AID2088, Type: screening]WEE1 homolog (S. pombe) [Homo sapiens] [gi:47123300]
View
20
[SID99495575]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
View
21
[SID99495575]
uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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22
[SID99495575]
Luminescence-based cell-based high throughput confirmation assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624378, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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23
[SID99495575]
Luminescence-based cell-based primary high throughput confirmation assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652260, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a [Homo sapiens] [gi:119579215]
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24
[SID99495575]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a [Homo sapiens] [gi:119579215]
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25
[SID87235992]
Late stage results from the probe development effort to identify inhibitors of Wee1 degradation. [AID2088_3, Type: screening]
View
26
[SID99495575]
Potency 1.4125qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
View
27
[SID99495575]
Potency 3.2643qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter [AID720537, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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28
[SID99495575]
AC50_uM 52Identification of VIF Inhibitors- ruling Out Cytotoxic Compounds Measured in Cell-Based System Using Imaging - 2108-02_Inhibitor_Dose_CherryPick_Activity [AID652208, Type: confirmatory]Vif [Human immunodeficiency virus 1] [gi:9629361]
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29
[SID87235992]
Cyclin B Degradation (EC50) 55.69Late stage results from the probe development effort to identify inhibitors of Wee1 degradation. [AID2088_2, Type: screening]cyclin B1 [Homo sapiens] [gi:119571691]
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30
[SID99495575]
High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity [AID651819, Type: screening]TRIC [Homo sapiens] [gi:83758679]
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31
[SID99495575]
qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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32
[SID99495575]
qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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33
[SID99495575]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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34
[SID99495575]
Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Human Bronchial Epithelial Cells. Measured in Cell-Based System Using Plate Reader - 7017-01_Other_SinglePoint_HTS_Activity [AID720511, Type: screening]cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7 [Homo sapiens] [gi:89348172]
View
35
[SID99495575]
QFRET-based biochemical high throughput primary assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) [AID743126, Type: screening]phospholipase A2, group III [Homo sapiens] [gi:119580345]
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36
[SID99495575]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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37
[SID99495575]
C. difficile toxins: HTS for inhibitors of TcdB glycohydrolase activity Measured in Biochemical System Using Plate Reader - 7074-01_Inhibitor_SinglePoint_HTS_Activity [AID652162, Type: screening]toxin B [Clostridium difficile 630] [gi:126698238]
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38
[SID99495575]
High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set [AID588499, Type: Literature]botulinum neurotoxin type A [Clostridium botulinum A str. ATCC 3502] [gi:148378801]
View
39
[SID99495575]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-beta3). [AID720704, Type: screening]Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] [gi:148745659]
View
40
[SID99495575]
Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]protein AF-9 isoform a [Homo sapiens] [gi:156104889]
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41
[SID99495575]
uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin-1 [gi:160877737]
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42
[SID99495575]
High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set [AID588497, Type: Literature]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
View
43
[SID99495575]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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44
[SID99495575]
Potency qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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45
[SID99495575]
Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_Activity [AID686992, Type: screening]E-selectin precursor [Homo sapiens] [gi:187960042]
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46
[SID99495575]
Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
View
47
[SID99495575]
Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_Activity [AID602329, Type: screening]DNA repair and recombination protein RAD54-like [Homo sapiens] [gi:216548193]
View
48
[SID99495575]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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49
[SID99495575]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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50
[SID99495575]
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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