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4-cyano-N-(2-(1-cyclohexen-1-yl)-4-(1-((dimethylamino)acetyl)-4-piperidinyl)phenyl)-1H-imidazole-2-carboxamide (CID 44551653) - Compound BioActivity Data
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BioActivity Outcomes:
Active(238)
 
 
Unspecified(204)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Literature(442)
 
 
 
BioActivity Types:
Kd(442)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 442    Data Row: 442   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID136941612]
Kd 0.00083Binding constant for RET(V804M) kinase domain [AID625124, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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2
[SID136941612]
Kd 0.0012Binding constant for RET(V804L) kinase domain [AID625123, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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3
[SID136941612]
Kd 0.0015Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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4
[SID136941612]
Kd 0.0023Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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5
[SID136941612]
Kd 0.0024Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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6
[SID136941612]
Kd 0.0032Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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7
[SID136941612]
Kd 0.0036Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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8
[SID136941612]
Kd 0.0041Binding constant for AMPK-alpha2 kinase domain [AID625047, Type: Literature]5'-AMP-activated protein kinase catalytic subunit alpha-2 [gi:20178276]
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9
[SID136941612]
Kd 0.0042Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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10
[SID136941612]
Kd 0.0053Binding constant for AXL kinase domain [AID624840, Type: Literature]Tyrosine-protein kinase receptor UFO [gi:239938818]
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11
[SID136941612]
Kd 0.0058Binding constant for TYK2(JH1domain-catalytic) kinase domain [AID624912, Type: Literature]Non-receptor tyrosine-protein kinase TYK2 [gi:56405328]
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12
[SID136941612]
Kd 0.006Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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13
[SID136941612]
Kd 0.0064Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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14
[SID136941612]
Kd 0.0072Binding constant for TAK1 kinase domain [AID624724, Type: Literature]Mitogen-activated protein kinase kinase kinase 7 [gi:12643557]
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15
[SID136941612]
Kd 0.0077Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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16
[SID136941612]
Kd 0.0092Binding constant for RET kinase domain [AID625121, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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17
[SID136941612]
Kd 0.0094Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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18
[SID136941612]
Kd 0.0099Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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19
[SID136941612]
Kd 0.0099Binding constant for CHEK1 kinase domain [AID624831, Type: Literature]Serine/threonine-protein kinase Chk1 [gi:317373343]
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20
[SID136941612]
Kd 0.01Binding constant for ACVR1B kinase domain [AID624943, Type: Literature]Activin receptor type-1B [gi:547775]
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21
[SID136941612]
Kd 0.011Binding constant for BLK kinase domain [AID624841, Type: Literature]Tyrosine-protein kinase Blk [gi:158936749]
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22
[SID136941612]
Kd 0.013Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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23
[SID136941612]
Kd 0.017Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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24
[SID136941612]
Kd 0.018Binding constant for KIT(D816V) kinase domain [AID624789, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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25
[SID136941612]
Kd 0.018Binding constant for STK16 kinase domain [AID624775, Type: Literature]Serine/threonine-protein kinase 16 [gi:46577677]
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26
[SID136941612]
Kd 0.018Binding constant for JAK3(JH1domain-catalytic) kinase domain [AID624785, Type: Literature]Tyrosine-protein kinase JAK3 [gi:50403745]
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27
[SID136941612]
Kd 0.02Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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28
[SID136941612]
Kd 0.027Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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29
[SID136941612]
Kd 0.028Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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30
[SID136941612]
Kd 0.031Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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31
[SID136941612]
Kd 0.034Binding constant for TTK kinase domain [AID624910, Type: Literature]Dual specificity protein kinase TTK [gi:160112977]
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32
[SID136941612]
Kd 0.039Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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33
[SID136941612]
Kd 0.039Binding constant for YSK4 kinase domain [AID625136, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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34
[SID136941612]
Kd 0.042Binding constant for MLCK kinase domain [AID624738, Type: Literature]Myosin light chain kinase 3 [gi:254763411]
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35
[SID136941612]
Kd 0.048Binding constant for KIT(D816H) kinase domain [AID624788, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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36
[SID136941612]
Kd 0.048Binding constant for MST1 kinase domain [AID625055, Type: Literature]Serine/threonine-protein kinase 4 [gi:13124559]
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37
[SID136941612]
Kd 0.053Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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38
[SID136941612]
Kd 0.056Binding constant for TRKA kinase domain [AID624808, Type: Literature]High affinity nerve growth factor receptor [gi:94730402]
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39
[SID136941612]
Kd 0.06Binding constant for KIT(A829P) kinase domain [AID624787, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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40
[SID136941612]
Kd 0.065Binding constant for MAP4K2 kinase domain [AID624959, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 2 [gi:215274019]
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41
[SID136941612]
Kd 0.068Binding constant for TRKC kinase domain [AID624765, Type: Literature]NT-3 growth factor receptor [gi:134035335]
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42
[SID136941612]
Kd 0.077Binding constant for BTK kinase domain [AID624779, Type: Literature]Tyrosine-protein kinase BTK [gi:547759]
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43
[SID136941612]
Kd 0.078Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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44
[SID136941612]
Kd 0.081Binding constant for MINK kinase domain [AID624813, Type: Literature]Misshapen-like kinase 1 [gi:296437370]
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45
[SID136941612]
Kd 0.081Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain [AID624810, Type: Literature]Eukaryotic translation initiation factor 2-alpha kinase 4 [gi:296439368]
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46
[SID136941612]
Kd 0.086Binding constant for MERTK kinase domain [AID624767, Type: Literature]Tyrosine-protein kinase Mer [gi:160332297]
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47
[SID136941612]
Kd 0.086Binding constant for MAP3K2 kinase domain [AID625062, Type: Literature]Mitogen-activated protein kinase kinase kinase 2 [gi:97536681]
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48
[SID136941612]
Kd 0.099Binding constant for MEK5 kinase domain [AID624721, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 5 [gi:118572669]
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49
[SID136941612]
Kd 0.1Binding constant for DDR2 kinase domain [AID624777, Type: Literature]Discoidin domain-containing receptor 2 [gi:215273969]
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50
[SID136941612]
Kd 0.12Binding constant for FER kinase domain [AID625010, Type: Literature]Tyrosine-protein kinase Fer [gi:97536202]
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