Vitamin A (CID 445354) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(83)
 
 
Inactive(676)
 
 
Inconclusive(273)
 
 
Unspecified(1430)
 
 
Top Targets:
NR LBD TR(14)
 
 
NR LBD PPAR(10)
 
 
 
NR LBD ROR li..(9)
 
 
 
7TM GPCR Srx(9)
 
 
HELICc(8)
 
 
BioAssay Types:
Confirmatory(418)
 
 
 
 
 
Screening(296)
 
 
 
 
Literature(118)
 
 
 
 
 
BioActivity Types:
Potency(306)
 
 
 
 
 
IC50(17)
 
 
 
 
Kd(3)
 
 
EC50(1)
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2088    Data Row: 2462   Total Pages: 50   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103260440]
GI50 0.028Growth inhibitory activity against human cancer cell line in the NCI?s anticancer drug screening program [AID247402, Type: Literature]
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2
[SID103260440]
Kd 0.036Binding affinity to bovine beta-lactoglobulins by fluorescence spectroscopy [AID445385, Type: Literature]Beta-lactoglobulin [gi:125910]
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3
[SID103260440]
Kd 0.07Dissociation constant with retinol binding protein was determined [AID199394, Type: Literature]
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4
[SID103260440]
Kd 0.2Binding affinity to reindeer beta-lactoglobulin by fluorescence spectroscopy [AID445386, Type: Literature]
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5
[SID26753110]
Potency 3.1623qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID26753110]
Potency 3.1623qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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7
[SID26753110]
Potency 3.1623qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID26753110]
Potency 3.1623qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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9
[SID17389530]
Potency 5.9672qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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10
[SID17389530]
Potency 5.9672qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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11
[SID104171352]
Potency 10.691Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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12
[SID17389530]
Potency 14.1254qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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13
[SID17389530]
Potency 14.1254qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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14
[SID17389530]
Potency 14.1254qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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15
[SID17389530]
Potency 14.1254qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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16
[SID17389530]
Potency 14.1254qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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17
[SID124883068]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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18
[SID103260440]
IC50 25Cytotoxicity against human normal fibroblast after 1 day by MTT assay [AID404772, Type: Literature]
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19
[SID26753109]
Potency 25.1189qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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20
[SID26753109]
Potency 25.1189qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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21
[SID17389530]
Potency 37.578qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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22
[SID17389530]
Potency 37.578qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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23
[SID17389530]
Potency 37.578qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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24
[SID17389530]
Potency 39.8107Cell Viability - LYMP2-022 [AID987, Type: confirmatory]
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25
[SID17389530]
Potency 39.8107Cell Viability - LYMP2-004 [AID966, Type: confirmatory]
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26
[SID17389530]
Potency 42.1632qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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27
[SID17389530]
Potency 42.1632qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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28
[SID17389530]
Potency 42.1632qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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29
[SID17389530]
Potency 42.1632qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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30
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-005 [AID967, Type: confirmatory]
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31
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-010 [AID981, Type: confirmatory]
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32
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-012 [AID982, Type: confirmatory]
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33
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-024 [AID988, Type: confirmatory]
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34
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-018 [AID985, Type: confirmatory]
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35
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-020 [AID986, Type: confirmatory]
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36
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-003 [AID965, Type: confirmatory]
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37
[SID47193665]
Potency 50.1187qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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38
[SID47193665]
Potency 50.1187qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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39
[SID144204369]
Potency 68.5896qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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40
[SID144204369]
Potency 68.5896qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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41
[SID144204369]
Potency 68.5896qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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42
[SID144204369]
Potency 68.5896qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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43
[SID17389530]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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44
[SID17389530]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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45
[SID103260440]
 Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis [AID606062, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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46
[SID26753110]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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47
[SID26753110]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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48
[SID47193688]
 MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]
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49
[SID47193665]
 RNA aptamer-based HTS for inhibitors of GRK2 [AID488847, Type: screening]beta-adrenergic receptor kinase 1 [Homo sapiens] [gi:148539876]
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50
[SID46393062]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystallographic Refinement Of Human Serum Retinol Binding Protein At 2 Angstroms Resolutio [gi:157833637]
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