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BioActivity Data for Compound Vitamin A (CID 445354)

BioActivity Outcomes:
Active(124)
 
 
Inactive(952)
 
 
Inconclusive(342)
 
 
Unspecified(1145)
 
 
Top Targets:
NR LBD PPAR(28)
 
 
 
 
7tm 4(28)
 
 
NR LBD AR(25)
 
 
 
 
NR LBD ER(25)
 
 
 
 
NR LBD TR(23)
 
 
 
 
BioAssay Types:
Confirmatory(663)
 
 
 
 
 
Screening(346)
 
 
 
 
Literature(166)
 
 
 
 
 
Summary(73)
 
 
 
 
BioAssay Categories:
In vitro(4)
 
 
 
In vivo(1071)
 
 
 
 
 
Biochemical(120)
 
 
 
 
 
Toxicity(1145)
 
 
 
 
 
ADME(36)
 
 
 
Cell-based(115)
 
 
 
 
 
Organism-base..(15)
 
 
 
 
BioActivity Types:
Potency(607)
 
 
 
 
 
IC50(17)
 
 
 
 
Kd(8)
 
 
Ki(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1953    Data Row: 2563   Total Pages: 129   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103260440]
GI50 0.028Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program [AID247402, Type: Literature]
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2
[SID103260440]
Kd 0.036Binding affinity to bovine beta-lactoglobulins by fluorescence spectroscopy [AID445385, Type: Literature]Beta-lactoglobulin [gi:125910]
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3
[SID103260440]
Kd 0.07Dissociation constant with retinol binding protein was determined [AID199394, Type: Literature]
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4
[SID103260440]
Kd 0.182Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis [AID606062, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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5
[SID46393062]
Kd 0.19Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystallographic Refinement Of Human Serum Retinol Binding Protein At 2 Angstroms Resolution [gi:157833637]
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6
[SID46393062]
Kd 0.19Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystallographic Refinement Of Human Serum Retinol Binding Protein At 2 Angstroms Resolution [gi:157833637]
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7
[SID103260440]
Kd 0.2Binding affinity to reindeer beta-lactoglobulin by fluorescence spectroscopy [AID445386, Type: Literature]
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8
[SID208011869]
Kd 0.43Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
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9
[SID208011869]
Kd 0.43Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
View
10
[SID144204369]
Potency-Replicate_1 0.9439qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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11
[SID17389530]
Potency-Replicate_1 2.8184qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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12
[SID26753110]
Potency 3.1623qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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13
[SID144209639]
Ratio Potency (uM) 3.31391qHTS assay to identify small molecule agonists of the RXR signaling pathway: Summary [AID1159531, Type: summary]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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14
[SID144210607]
Ratio Potency (uM) 4.34379qHTS assay to identify small molecule agonists of the RXR signaling pathway: Summary [AID1159531, Type: summary]retinoid X nuclear receptor alpha [Homo sapiens] [gi:325495497]
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15
[SID17389530]
Potency 5.9672qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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16
[SID26753110]
Potency-Replicate_1 7.0795qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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17
[SID144209639]
Potency-Replicate_1 7.7899qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
18
[SID144204369]
Potency-Replicate_1 8.4852qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID104171352]
Potency 10.691Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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20
[SID17389530]
Potency 14.1254qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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