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Vitamin A (CID 445354) - Compound BioActivity Data
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BioActivity Outcomes:
Active(117)
 
 
Inactive(905)
 
 
Inconclusive(346)
 
 
Unspecified(1451)
 
 
Top Targets:
NR LBD PPAR(28)
 
 
 
 
NR LBD ER(25)
 
 
 
 
NR LBD AR(25)
 
 
 
 
NR LBD TR(23)
 
 
 
 
NR LBD GR(16)
 
 
 
 
BioAssay Types:
Confirmatory(639)
 
 
 
 
 
Screening(344)
 
 
 
 
Literature(131)
 
 
 
 
 
Summary(63)
 
 
 
 
BioActivity Types:
Potency(572)
 
 
 
 
 
IC50(17)
 
 
 
 
Kd(3)
 
 
Ki(1)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2236    Data Row: 2819   Total Pages: 57   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103260440]
GI50 0.028Growth inhibitory activity against human cancer cell line in the NCI inverted question marks anticancer drug screening program [AID247402, Type: Literature]
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2
[SID103260440]
Kd 0.036Binding affinity to bovine beta-lactoglobulins by fluorescence spectroscopy [AID445385, Type: Literature]Beta-lactoglobulin [gi:125910]
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3
[SID103260440]
Kd 0.07Dissociation constant with retinol binding protein was determined [AID199394, Type: Literature]
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4
[SID103260440]
Kd 0.2Binding affinity to reindeer beta-lactoglobulin by fluorescence spectroscopy [AID445386, Type: Literature]
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5
[SID144204369]
Potency-Replicate_1 0.9439qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID17389530]
Potency-Replicate_1 2.8184qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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7
[SID26753110]
Potency 3.1623qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID17389530]
Potency 5.9672qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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9
[SID26753110]
Potency-Replicate_1 7.0795qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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10
[SID144204369]
Potency-Replicate_1 8.4852qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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11
[SID104171352]
Potency 10.691Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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12
[SID17389530]
Potency 14.1254qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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13
[SID144209639]
ER Potency (uM) 18.1217qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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14
[SID144204369]
Ratio Potency (uM) 20.4913qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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15
[SID124883068]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID144209639]
Potency-Replicate_1 21.9549qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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17
[SID144210607]
Potency-Replicate_1 22.8642qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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18
[SID144210607]
Potency-Replicate_1 22.8642qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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19
[SID144204369]
ER Potency (uM) 23.7101qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID144209639]
Potency-Replicate_1 24.6338qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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21
[SID103260440]
IC50 25Cytotoxicity against human normal fibroblast after 1 day by MTT assay [AID404772, Type: Literature]
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22
[SID26753109]
Potency 25.1189qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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23
[SID144204369]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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24
[SID144210607]
Potency-Replicate_1 28.7843qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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25
[SID144210607]
Potency-Replicate_1 28.7843qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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26
[SID17389530]
Potency 37.578qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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27
[SID17389530]
Potency 39.8107Cell Viability - LYMP2-022 [AID987, Type: confirmatory]
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28
[SID17389530]
Potency 39.8107Cell Viability - LYMP2-004 [AID966, Type: confirmatory]
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29
[SID17389530]
Potency 42.1632qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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30
[SID144209639]
Potency-Replicate_1 43.8058qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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31
[SID144209639]
Ratio Potency (uM) 49.5839qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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32
[SID47193665]
Potency 50.1187qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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33
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-005 [AID967, Type: confirmatory]
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34
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-003 [AID965, Type: confirmatory]
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35
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-024 [AID988, Type: confirmatory]
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36
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-018 [AID985, Type: confirmatory]
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37
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-020 [AID986, Type: confirmatory]
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38
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-010 [AID981, Type: confirmatory]
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39
[SID17389530]
Potency 50.1187Cell Viability - LYMP2-012 [AID982, Type: confirmatory]
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40
[SID144209639]
Potency-Replicate_1 55.1482qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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41
[SID144209639]
Potency-Replicate_1 55.6341qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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42
[SID144210607]
Potency-Replicate_1 57.4322qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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43
[SID144210607]
Ratio Potency (uM) 59.6791qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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44
[SID144210607]
Ratio Potency (uM) 60.1915qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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45
[SID144209639]
Potency-Replicate_1 61.8773qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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46
[SID144209639]
Ratio Potency (uM) 61.8773qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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47
[SID144209639]
Potency-Replicate_1 61.8773qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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48
[SID144209639]
Potency-Replicate_1 61.8773qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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49
[SID144209639]
Potency-Replicate_1 61.8773qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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50
[SID144204369]
Potency 68.5896qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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