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resveratrol (CID 445154) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(496)
 
 
Inactive(1410)
 
 
Inconclusive(247)
 
 
Unspecified(796)
 
 
Top Targets:
7TM GPCR Srx(47)
 
 
 
NR LBD ER(43)
 
 
 
 
 
NR LBD PPAR(40)
 
 
 
 
7TM GPCR Srsx(39)
 
 
 
p450(28)
 
 
 
 
 
BioAssay Types:
Literature(1064)
 
 
 
 
 
Confirmatory(947)
 
 
 
 
 
Screening(660)
 
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(811)
 
 
 
 
 
IC50(340)
 
 
 
 
 
EC50(30)
 
 
 
 
Ki(21)
 
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2380    Data Row: 2949   Total Pages: 59   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103259583]
IC50 2.25e-05Antiproliferative activity against human HeLa cells assessed as cell viability after 48 hrs by SRB assay [AID620775, Type: Literature]
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2
[SID103259583]
IC50 4.03e-05Antiproliferative activity against human SK-N-SH cells assessed as cell viability after 48 hrs by SRB assay [AID620727, Type: Literature]
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3
[SID103259583]
IC50 4.47e-05Antiproliferative activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay [AID620728, Type: Literature]
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4
[SID103259583]
IC50 7.91e-05Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by SRB assay [AID620726, Type: Literature]
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5
[SID144208572]
Potency-Replicate_1 0.0088qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID103259583]
Ki 0.169Binding affinity for aryl hydrocarbon receptor (AhR) of rabbit liver cytosol incubated with 0.2 nM [3H]-TCDD; Antagonist [AID239550, Type: Literature]
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7
[SID103259583]
IC50 0.173Inhibition of TNF-alpha-induced NF-kappaB activity expressed in HEK293 cells after 48 hrs by luciferase reporter gene assay [AID491619, Type: Literature]
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8
[SID103259583]
IC50 0.38Inhibition of ovine COX1 [AID271286, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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9
[SID103259583]
IC50 0.449DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) [AID625150, Type: other]Amine oxidase [flavin-containing] A [gi:113978]
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10
[SID103259583]
IC50 0.45Inhibition of human recombinant NQO2 by spectrophotometry [AID459814, Type: Literature]Ribosyldihydronicotinamide dehydrogenase [quinone] [gi:317373581]
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11
[SID103259583]
IC50 0.45Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometry [AID479979, Type: Literature]Ribosyldihydronicotinamide dehydrogenase [quinone] [gi:317373581]
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12
[SID103259583]
Kd 0.5Binding affinity to amyloid beta (1 to 40) in APP/PS1 transgenic mouse brain by fluorescence titration analysis [AID528473, Type: Literature]
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13
[SID103259583]
IC50 0.535Inhibition of ovine COX1 by measuring PGE2 [AID289278, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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14
[SID103259583]
IC50 0.6DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
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15
[SID103259583]
IC50 0.625DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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16
[SID144208572]
Potency-Replicate_1 0.6922qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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17
[SID49734167]
AbsAC40_uM 0.719MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_Dose_CherryPick_Activity [AID540258, Type: confirmatory]
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18
[SID103259583]
IC50 0.75Inhibition of human recombinant COX2 assessed as PGE2 production after 10 mins by ELISA [AID491615, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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19
[SID103259583]
Ki 0.785Binding affinity for estrogen receptor (ER) alpha of MCF-7 cell cytosol incubated with 2 nM [3H]estradiol; Agonist [AID239674, Type: Literature]
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20
[SID103259583]
Ki 0.81Inhibition of human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration method [AID502077, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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21
[SID103259583]
Ki 0.83Inhibition of human carbonic anhydrase 14 after 15 mins by stopped flow CO2 hydration method [AID501914, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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22
[SID103259583]
IC50 0.83Inhibition of COX1 [AID370919, Type: Literature]
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23
[SID103259583]
Ki 0.95Inhibition of human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration method [AID501912, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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24
[SID103259583]
IC50 0.96Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) assessed as N-methyldihydronicotinamide oxidation per mg of protein after 1 hr by LC-MS analysis analysis [AID587229, Type: Literature]Ribosyldihydronicotinamide dehydrogenase [quinone] [gi:317373581]
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25
[SID103259583]
IC50 0.96Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) incubated at 23 degC by MTT assay [AID418720, Type: Literature]Ribosyldihydronicotinamide dehydrogenase [quinone] [gi:317373581]
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26
[SID144213690]
Potency-Replicate_1 0.9689qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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27
[SID103259583]
IC50 0.98Inhibition of TNF-alpha activated NF-kappaB expressed in HEK293 cells by luciferase reporter gene assay [AID650848, Type: Literature]
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28
[SID103259583]
IC50 0.98Inhibition of TNFalpha-induced NF-kappaB activity expressed in HEK293 cells by luciferase reporter gene assay [AID719269, Type: Literature]
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29
[SID103259583]
IC50 0.98Inhibition of TNFalpha-activated NF-kappaB expressed in HEK293 cells by luciferase reporter gene assay [AID642338, Type: Literature]
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30
[SID103259583]
IC50 0.99Inhibition of COX2 [AID370920, Type: Literature]
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31
[SID103259583]
IC50 0.996Inhibition of human recombinant COX2 by measuring PGE2 [AID289279, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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32
[SID103259583]
IC50 1.1Inhibition of COX1 [AID332217, Type: Literature]
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33
[SID144213690]
Ratio Potency (uM) 1.29199qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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34
[SID103259583]
IC50 1.3Inhibition of COX2 [AID332218, Type: Literature]
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35
[SID144208572]
Ratio Potency (uM) 1.38108qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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36
[SID144208572]
Ratio Potency (uM) 1.39233qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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37
[SID103259583]
EC50 1.44Cytoprotectant activity against L-buthionine-(S,R)-sulfoximine-induced cell death in Friedreich ataxia patient fibroblasts assessed as increase of cell viability [AID611404, Type: Literature]
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38
[SID26747076]
Potency 1.7783qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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39
[SID17388746]
Potency 1.8834qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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40
[SID855986]
Potency 1.9012qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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41
[SID855986]
Potency 1.9953qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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42
[SID144203808]
Potency-Replicate_1 2.1119qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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43
[SID103259583]
Ki 2.21Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration method [AID501903, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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44
[SID855986]
Potency 2.2387qHTS Assay Multiplex Screening to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (Protease relase) [AID2669, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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45
[SID855986]
IC50 2.242QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2195, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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46
[SID103259583]
IC50 2.312DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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47
[SID103259583]
IC50 2.4Antioxidant activity against cupric ion-induced lipid peroxidation in human LDL by TBA assay [AID401040, Type: Literature]
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48
[SID144203808]
Ratio Potency (uM) 2.45471qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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49
[SID144208572]
Potency-Replicate_1 2.4559qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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50
[SID144203808]
Potency-Replicate_1 2.5429qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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