resveratrol (CID 445154) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(370)
 
 
Inactive(1127)
 
 
Inconclusive(155)
 
 
Unspecified(684)
 
 
Top Targets:
7TM GPCR Srx(36)
 
 
 
NR LBD ER(22)
 
 
 
 
 
prostaglandin..(22)
 
 
 
 
p450(20)
 
 
 
 
7TM GPCR Srsx(20)
 
 
 
BioAssay Types:
Literature(868)
 
 
 
 
 
Confirmatory(681)
 
 
 
 
 
Screening(585)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(505)
 
 
 
 
 
IC50(301)
 
 
 
 
 
EC50(26)
 
 
 
 
Ki(21)
 
 
 
AC50(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2051    Data Row: 2336   Total Pages: 47   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103259583]
IC50 2.25e-05Antiproliferative activity against human HeLa cells assessed as cell viability after 48 hrs by SRB assay [AID620775, Type: Literature]
View
2
[SID103259583]
IC50 4.03e-05Antiproliferative activity against human SK-N-SH cells assessed as cell viability after 48 hrs by SRB assay [AID620727, Type: Literature]
View
3
[SID103259583]
IC50 4.47e-05Antiproliferative activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay [AID620728, Type: Literature]
View
4
[SID103259583]
IC50 7.91e-05Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by SRB assay [AID620726, Type: Literature]
View
5
[SID103259583]
Ki 0.169Binding affinity for aryl hydrocarbon receptor (AhR) of rabbit liver cytosol incubated with 0.2 nM [3H]-TCDD; Antagonist [AID239550, Type: Literature]
View
6
[SID103259583]
IC50 0.173Inhibition of TNF-alpha-induced NF-kappaB activity expressed in HEK293 cells after 48 hrs by luciferase reporter gene assay [AID491619, Type: Literature]
View
7
[SID103259583]
IC50 0.38Inhibition of ovine COX1 [AID271286, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
8
[SID103259583]
IC50 0.449DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) [AID625150, Type: other]Amine oxidase [flavin-containing] A [gi:113978]
View
9
[SID103259583]
IC50 0.45Inhibition of human recombinant NQO2 assessed as reduction of DCPIP by spectrophotometry [AID479979, Type: Literature]Ribosyldihydronicotinamide dehydrogenase [quinone] [gi:317373581]
View
10
[SID103259583]
IC50 0.45Inhibition of human recombinant NQO2 by spectrophotometry [AID459814, Type: Literature]Ribosyldihydronicotinamide dehydrogenase [quinone] [gi:317373581]
View
11
[SID103259583]
Kd 0.5Binding affinity to amyloid beta (1 to 40) in APP/PS1 transgenic mouse brain by fluorescence titration analysis [AID528473, Type: Literature]
View
12
[SID103259583]
IC50 0.535Inhibition of ovine COX1 by measuring PGE2 [AID289278, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
13
[SID103259583]
IC50 0.6DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
View
14
[SID103259583]
IC50 0.6DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
View
15
[SID103259583]
IC50 0.6DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
View
16
[SID103259583]
IC50 0.625DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
View
17
[SID49734167]
AbsAC40_uM 0.719MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_Dose_CherryPick_Activity [AID540258, Type: confirmatory]
View
18
[SID103259583]
IC50 0.75Inhibition of human recombinant COX2 assessed as PGE2 production after 10 mins by ELISA [AID491615, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
19
[SID103259583]
Ki 0.785Binding affinity for estrogen receptor (ER) alpha of MCF-7 cell cytosol incubated with 2 nM [3H]estradiol; Agonist [AID239674, Type: Literature]
View
20
[SID103259583]
Ki 0.81Inhibition of human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration method [AID502077, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
View
21
[SID103259583]
IC50 0.83Inhibition of COX1 [AID370919, Type: Literature]
View
22
[SID103259583]
Ki 0.83Inhibition of human carbonic anhydrase 14 after 15 mins by stopped flow CO2 hydration method [AID501914, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
View
23
[SID103259583]
Ki 0.95Inhibition of human carbonic anhydrase 12 after 15 mins by stopped flow CO2 hydration method [AID501912, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
View
24
[SID103259583]
IC50 0.96Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) incubated at 23 degC by MTT assay [AID418720, Type: Literature]Ribosyldihydronicotinamide dehydrogenase [quinone] [gi:317373581]
View
25
[SID103259583]
IC50 0.96Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) assessed as N-methyldihydronicotinamide oxidation per mg of protein after 1 hr by LC-MS analysis analysis [AID587229, Type: Literature]Ribosyldihydronicotinamide dehydrogenase [quinone] [gi:317373581]
View
26
[SID103259583]
IC50 0.98Inhibition of TNFalpha-activated NF-kappaB expressed in HEK293 cells by luciferase reporter gene assay [AID642338, Type: Literature]
View
27
[SID103259583]
IC50 0.98Inhibition of TNF-alpha activated NF-kappaB expressed in HEK293 cells by luciferase reporter gene assay [AID650848, Type: Literature]
View
28
[SID103259583]
IC50 0.99Inhibition of COX2 [AID370920, Type: Literature]
View
29
[SID103259583]
IC50 0.996Inhibition of human recombinant COX2 by measuring PGE2 [AID289279, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
View
30
[SID103259583]
IC50 1.1Inhibition of COX1 [AID332217, Type: Literature]
View
31
[SID103259583]
IC50 1.3Inhibition of COX2 [AID332218, Type: Literature]
View
32
[SID103259583]
EC50 1.44Cytoprotectant activity against L-buthionine-(S,R)-sulfoximine-induced cell death in Friedreich ataxia patient fibroblasts assessed as increase of cell viability [AID611404, Type: Literature]
View
33
[SID26747076]
Potency 1.7783qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
34
[SID17388746]
Potency 1.8834qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
View
35
[SID855986]
Potency 1.9012qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
36
[SID855986]
Potency 1.9953qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
37
[SID103259583]
Ki 2.21Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration method [AID501903, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
38
[SID855986]
Potency 2.2387qHTS Assay Multiplex Screening to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (Protease relase) [AID2669, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
View
39
[SID855986]
Potency 2.2387qHTS Assay Multiplex Screening to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (Protease relase) [AID2669, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
View
40
[SID855986]
IC50 2.242QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2195, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
View
41
[SID855986]
IC50 2.242QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID2195, Type: confirmatory]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
View
42
[SID103259583]
IC50 2.312DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
View
43
[SID103259583]
IC50 2.312DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
View
44
[SID103259583]
IC50 2.4Antioxidant activity against cupric ion-induced lipid peroxidation in human LDL by TBA assay [AID401040, Type: Literature]
View
45
[SID103259583]
Ki 2.77Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration method [AID501904, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
46
[SID103259583]
IC50 2.8Inhibition of peroxidase activity of COX1 in heep seminal vesicle by TMPD assay [AID333439, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
View
47
[SID103259583]
IC50 2.84Inhibition of COX1 assessed as TBX2 production in human whole blood [AID271283, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
View
48
[SID90341821]
Potency 2.9081Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493106, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
View
49
[SID103259583]
IC50 3DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: other]Cytochrome P450 1A2 [gi:117144]
View
50
[SID103259583]
IC50 3DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: other]Cytochrome P450 1A2 [gi:117144]
View