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fumaric acid (CID 444972) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(751)
 
 
Inconclusive(18)
 
 
Unspecified(20)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
NR LBD ER(16)
 
 
 
NR LBD AR(16)
 
 
 
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(12)
 
 
BioAssay Types:
Confirmatory(429)
 
 
 
 
 
Screening(262)
 
 
 
Summary(48)
 
 
 
 
Literature(37)
 
 
 
 
BioActivity Types:
Potency(365)
 
 
 
 
 
IC50(14)
 
 
 
 
Ki(2)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 655    Data Row: 798   Total Pages: 40   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144208967]
Potency-Replicate_1 2.3087qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID144213143]
Ratio Potency (uM) 11.296qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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3
[SID103648919]
IC50 19Inhibition of 2-oxoglutarate-dependent human recombinant HIF PHD2 preincubated for 1 hr [AID344926, Type: Literature]Egl nine homolog 1 [gi:32129514]
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4
[SID103648919]
IC50 19.09Destabilizing effect on human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) assessed as half life by limited trypsinolysis/MALDI-MS analysis in presence of ferrous ion [AID349748, Type: Literature]
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5
[SID144208967]
Potency-Replicate_1 36.2726qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID144208967]
Ratio Potency (uM) 55.9838qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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7
[SID103648919]
Inhibition of human recombinant carbonic anhydrase 5A by stopped flow CO2 hydration method [AID456399, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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8
[SID103648919]
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method [AID456397, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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9
[SID103648919]
Inhibition of human recombinant carbonic anhydrase 5B by stopped flow CO2 hydration method [AID456400, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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10
[SID103648919]
IC50 150Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichia coli BL21 (DE3) using 3-methylthymidine as substrate assessed as inhibition of 3-methylthymidine conversion to thymidine after 1 hr by liquid chromatographic analysis [AID734755, Type: Literature]Alpha-ketoglutarate-dependent dioxygenase FTO [gi:148841515]
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11
[SID103648919]
Kd 200Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis [AID721525, Type: Literature]Egl nine homolog 1 [gi:32129514]
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12
[SID103648919]
IC50 220Inhibition of human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis [AID721523, Type: Literature]Egl nine homolog 1 [gi:32129514]
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13
[SID103648919]
Ki 616.595Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr [AID360150, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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14
[SID103648919]
IC50 1600Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess H3K9me3 peptide and 10 uM Fe2 by FDH coupled assay [AID344917, Type: Literature]
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15
[SID103648919]
IC50 2300Inhibition of 2-oxoglutarate-dependent human JMJD2E preincubated for 30 mins by FDH coupled assay [AID344918, Type: Literature]
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16
[SID103648919]
IC50 10000Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess 2-oxoglutarate and 10 uM Fe2 by FDH coupled assay [AID344916, Type: Literature]
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17
[SID103648919]
Ki 31622.8Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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18
[SID103648919]
Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method [AID456398, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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19
[SID103648919]
Inhibition of human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) by TR-FRET assay [AID349747, Type: Literature]
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20
[SID103648919]
Selectivity ratio of Kinact for human recombinant carbonic anhydrase 1 to Kinact for human recombinant carbonic anhydrase 5A [AID456401, Type: Literature]
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