Bookmark and Share
SureCN12474972 (CID 44495835) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(13)
 
 
Inactive(57)
 
 
Inconclusive(3)
 
 
Unspecified(2)
 
 
Top Targets:
HLH(2)
 
 
rad52(1)
 
 
YEATS(1)
 
 
TcdA TcdB por..(1)
 
 
STKc STK33(1)
 
 
BioAssay Types:
Screening(48)
 
 
 
Confirmatory(17)
 
 
 
 
Literature(5)
 
 
 
 
BioActivity Types:
IC50(11)
 
 
 
AC50(6)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 71    Data Row: 75   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134958999]
AC50_uM 0.00127Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_Dose_DryPowder_Activity_Set2 [AID652275, Type: confirmatory]
View
2
[SID134958999]
Average IC50 (uM) 0.0098Inhibition of intracellular CAI/72 strain of Trypanosoma cruzi in bovine embryo skeletal muscle cells: high content imaging Measured in Cell-Based System Using Imaging - 2138-07_Inhibitor_SinglePoint_DryPowder_Activity [AID651885, Type: confirmatory]
View
3
[SID134958999]
AC50_uM 0.0158Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_Dose_DryPowder_Activity [AID651845, Type: confirmatory]
View
4
[SID85802685]
AC50_uM 0.075Intracellular Trypanosomes Measured in Cell-Based/Microorganism System Using Plate Reader - 2017-01_Inhibitor_Dose_CherryPick_Activity_Set3 [AID651818, Type: confirmatory]
View
5
[SID134958999]
IC50_uM 0.0755Inhibition of T. cruzi Tulahuen strain amastigotes in L-6 muscle cells Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2138-03_Inhibitor_Dose_DryPowder_Activity [AID651890, Type: confirmatory]
View
6
[SID85802685]
IC50_uM 1.82Inhibition of T. cruzi Tulahuen strain amastigotes in L-6 muscle cells Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2138-03_Inhibitor_Dose_CherryPick_Activity [AID651881, Type: confirmatory]
View
7
[SID85802685]
IC50_uM 1.82Inhibition of Plasmodium falcipirum NF54 Measured in Cell-Based System Using Plate Reader - 2138-11_Inhibitor_Dose_CherryPick_Activity [AID651888, Type: confirmatory]
View
8
[SID85802685]
IC50_uM 52.2L-6 rat myocyte cell toxicity Measured in Cell-Based System Using Plate Reader - 2138-06_Inhibitor_Dose_CherryPick_Activity [AID651896, Type: confirmatory]
View
9
[SID134958999]
Cidal vs. static assay: inhibition of T. cruzi (CAI/72) after prolonged treatment and treatment withdrawal Measured in Cell-Based System Using Imaging - 2138-08_Inhibitor_SinglePoint_DryPowder_Activity_Set2 [AID651869, Type: other]
View
10
[SID134958999]
Cidal vs. static assay: inhibition of T. cruzi (CAI/72) after prolonged treatment and treatment withdrawal Measured in Cell-Based System Using Imaging - 2138-08_Inhibitor_SinglePoint_DryPowder_Activity [AID651877, Type: other]
View
11
[SID85802685]
Intracellular Trypanosomes Measured in Cell-Based/Microorganism System Using Plate Reader - 2017-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651903, Type: screening]
View
12
[SID194161895]
Trypanocidal activity against Trypanosoma cruzi CA-I/72 infected in BESM cells assessed as parasite re-emergence at 370 nM treated for 29 days measured after 36 days [AID1065111, Type: Literature]
View
13
[SID194161895]
Trypanocidal activity against Trypanosoma cruzi CA-I/72 infected in BESM cells assessed as parasite re-emergence at 370 nM measured over 29 days of drug treatment [AID1065112, Type: Literature]
View
14
[SID194161895]
Metabolic stability in human plasma [AID1065119, Type: Literature]
View
15
[SID194161895]
Metabolic stability in mouse microsomes assessed as compound remaining at 1 uM after 1 hr [AID1065120, Type: Literature]
View
16
[SID134958999]
IC50_uM 2.32Inhibition of Plasmodium falcipirum NF54 Measured in Cell-Based System Using Plate Reader - 2138-11_Inhibitor_Dose_DryPowder_Activity [AID651889, Type: confirmatory]
View
17
[SID85802685]
IC50_uM 18.5Inhibition of Trypanosoma brucei rhodesiense STIB900 Measured in Cell-Based System Using Plate Reader - 2138-05_Inhibitor_Dose_CherryPick_Activity [AID651893, Type: confirmatory]
View
18
[SID134958999]
IC50_uM 22.2Inhibition of Trypanosoma brucei rhodesiense STIB900 Measured in Cell-Based System Using Plate Reader - 2138-05_Inhibitor_Dose_DryPowder_Activity [AID651894, Type: confirmatory]
View
19
[SID134958999]
IC50_uM 54.7L-6 rat myocyte cell toxicity Measured in Cell-Based System Using Plate Reader - 2138-06_Inhibitor_Dose_DryPowder_Activity [AID651895, Type: confirmatory]
View
20
[SID134958999]
IC50_uM 100Inhibition of L. donovani axenic amastigotes Measured in Cell-Based System Using Plate Reader - 2138-04_Inhibitor_Dose_DryPowder_Activity [AID651892, Type: confirmatory]
View