SureCN12474972 (CID 44495835) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(47)
 
 
Top Targets:
HLH(2)
 
 
rad52(1)
 
 
YEATS(1)
 
 
STKc AGC(1)
 
 
STAT bind(1)
 
 
BioAssay Types:
Screening(44)
 
 
 
Confirmatory(7)
 
 
 
BioActivity Types:
IC50(5)
 
 
 
AC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 52    Data Row: 52   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85802685]
AC50 0.075Intracellular Trypanosomes Measured in Cell-Based/Microorganism System Using Plate Reader - 2017-01_Inhibitor_Dose_CherryPick_Activity_Set3 [AID651818, Type: confirmatory]
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2
[SID85802685]
IC50 1.82Inhibition of T. cruzi Tulahuen strain amastigotes in L-6 muscle cells Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2138-03_Inhibitor_Dose_CherryPick_Activity [AID651881, Type: confirmatory]
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3
[SID85802685]
IC50 1.82Inhibition of Plasmodium falcipirum NF54 Measured in Cell-Based System Using Plate Reader - 2138-11_Inhibitor_Dose_CherryPick_Activity [AID651888, Type: confirmatory]
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4
[SID85802685]
IC50 52.2L-6 rat myocyte cell toxicity Measured in Cell-Based System Using Plate Reader - 2138-06_Inhibitor_Dose_CherryPick_Activity [AID651896, Type: confirmatory]
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5
[SID85802685]
 Intracellular Trypanosomes Measured in Cell-Based/Microorganism System Using Plate Reader - 2017-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651903, Type: screening]
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6
[SID85802685]
IC50 18.5Inhibition of Trypanosoma brucei rhodesiense STIB900 Measured in Cell-Based System Using Plate Reader - 2138-05_Inhibitor_Dose_CherryPick_Activity [AID651893, Type: confirmatory]
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7
[SID85802685]
IC50 100Inhibition of L. donovani axenic amastigotes Measured in Cell-Based System Using Plate Reader - 2138-04_Inhibitor_Dose_CherryPick_Activity [AID651891, Type: confirmatory]
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8
[SID85802685]
 HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_SinglePoint_HTS_Activity [AID651654, Type: screening]
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9
[SID85802685]
 DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity [AID651640, Type: screening]
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10
[SID85802685]
 Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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11
[SID85802685]
 MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_Activity [AID651687, Type: screening]
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12
[SID85802685]
 Luminescence Cell-Based Primary HTS to Identify Activators of the Reversal of PD-1 Mediated Inhibitors of T-Cell Inhibition [AID2316, Type: screening]
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13
[SID85802685]
 Fluorescence Cell-Based Primary HTS to Measure Inhibition of Y box Binding Protein 1 Expression [AID434959, Type: screening]
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14
[SID85802685]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of the Sonic Hedgehog Signaling Pathway [AID2313, Type: screening]
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15
[SID85802685]
 Luminescence Cell-Based Primary HTS to Measure Viability of BJeLR cells [AID2275, Type: screening]
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16
[SID85802685]
 Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_Activity [AID602342, Type: screening]
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17
[SID85802685]
 Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity [AID602363, Type: screening]
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18
[SID85802685]
 Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Activator_SinglePoint_HTS_Activity [AID623901, Type: screening]
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19
[SID85802685]
 Detect Cellular ATP-levels in INS-1E Cells Measured in Cell-Based System Using Plate Reader - 2061-01_Inhibitor_SinglePoint_HTS_Activity [AID488910, Type: screening]
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20
[SID85802685]
 Luminescence Cell-Based Primary HTS to Identify Re-Activators of the P53 Mutant Pathway Measured in Cell-Based System Using Plate Reader - 2071-01_Activator_SinglePoint_HTS_Activity [AID624151, Type: screening]
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21
[SID85802685]
 Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity [AID624156, Type: screening]
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22
[SID85802685]
 Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_SinglePoint_HTS_Activity [AID624255, Type: screening]
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23
[SID85802685]
 HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_Activity [AID602340, Type: screening]
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24
[SID85802685]
 MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_Activity [AID651723, Type: screening]
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25
[SID85802685]
AC50 NIH/3T3 (mouse embryonic fibroblast ) toxicity Measured in Cell-Based System Using Plate Reader - 2017-02_Inhibitor_Dose_CherryPick_Activity_Set2 [AID651817, Type: confirmatory]
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26
[SID85802685]
 VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]
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27
[SID85802685]
 PgID: DNTB colorimetric HTS to detect inhibitor of PgID Measured in Biochemical System Using Plate Reader - 2164-01_Inhibitor_SinglePoint_HTS_Activity [AID602405, Type: screening]WlaI protein (PglD) [gi:75495260]
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28
[SID85802685]
 ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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29
[SID85802685]
 ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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30
[SID85802685]
 Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta Complex [AID434961, Type: other]regulator of chromosome condensation isoform c [Homo sapiens] [gi:4502801]
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31
[SID85802685]
 EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Reader - 2125-01_Inhibitor_SinglePoint_HTS_Activity [AID651548, Type: screening]EZH2 gene product [Homo sapiens] [gi:21361095]
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32
[SID85802685]
 SMM ID4 Measured in Biochemical System Using Small Molecule MicroArray - 2128-01_Other_SinglePoint_HTS_Activity [AID624137, Type: screening]Id4 [Homo sapiens] [gi:881546]
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33
[SID85802685]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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34
[SID85802685]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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35
[SID85802685]
 Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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36
[SID85802685]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of MITF [AID2240, Type: screening]microphthalmia-associated transcription factor isoform 1 [Homo sapiens] [gi:38156699]
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37
[SID85802685]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of MITF [AID2240, Type: screening]microphthalmia-associated transcription factor isoform 1 [Homo sapiens] [gi:38156699]
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38
[SID85802685]
 Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]MLLT3 gene product [Homo sapiens] [gi:156104889]
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39
[SID85802685]
 SMM c-myc Measured in Biochemical System Using Small Molecule MicroArray - 2081-01_Other_SinglePoint_HTS_Activity [AID624141, Type: screening]MYC gene product [Homo sapiens] [gi:71774083]
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40
[SID85802685]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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41
[SID85802685]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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42
[SID85802685]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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43
[SID85802685]
 NF-KappaB Measured in Biochemical System Using Small Molecule MicroArray - 2080-01_Other_SinglePoint_HTS_Activity [AID624139, Type: screening]NFKB1 gene product [Homo sapiens] [gi:34577122]
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44
[SID85802685]
 FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651710, Type: screening]RAD52 gene product [Homo sapiens] [gi:109637798]
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45
[SID85802685]
 S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_Activity [AID652163, Type: screening]S100A4 [Homo sapiens] [gi:47496637]
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46
[SID85802685]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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47
[SID85802685]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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48
[SID85802685]
 SMM STAT-3 Measured in Biochemical System Using Small Molecule MicroArray - 2076-01_Other_SinglePoint_HTS_Activity_Set2 [AID624138, Type: screening]STAT3 gene product [Homo sapiens] [gi:21618340]
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49
[SID85802685]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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50
[SID85802685]
 mutant P53 Measured in Biochemical System Using Small Molecule MicroArray - 2077-01_Other_SinglePoint_HTS_Activity [AID624136, Type: screening]mutant p53 [Homo sapiens] [gi:208342286]
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