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BioActivity Data for Compound CHEMBL3109371 (CID 44495351)

BioActivity Outcomes:
Active(7)
 
 
Inactive(57)
 
 
Inconclusive(3)
 
 
Unspecified(4)
 
 
Top Targets:
HLH(2)
 
 
CASc(1)
 
 
OAT like(1)
 
 
DUF3371(1)
 
 
RHD-n NFkB1(1)
 
 
BioAssay Types:
Screening(51)
 
 
 
Confirmatory(11)
 
 
 
Literature(6)
 
 
 
BioActivity Types:
IC50(8)
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 67    Data Row: 71   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134216474]
AC50_uM 0.276Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_Dose_DryPowder_Activity_Set2 [AID652275, Type: confirmatory]
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2
[SID194160094]
IC50 0.45Antitrypanosomal activity against Trypanosoma cruzi Tulahuen infected in mouse NIH/3T3 cells assessed as multimode parasite growth inhibition after 4 days by beta-galactosidase reporter gene assay [AID1065124, Type: Literature]
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3
[SID134216474]
AC50_uM 0.506Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_Dose_DryPowder_Activity [AID651845, Type: confirmatory]
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4
[SID134216474]
Average IC50 (uM) 0.55Inhibition of intracellular CAI/72 strain of Trypanosoma cruzi in bovine embryo skeletal muscle cells: high content imaging Measured in Cell-Based System Using Imaging - 2138-07_Inhibitor_SinglePoint_DryPowder_Activity [AID651885, Type: confirmatory]
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5
[SID134216474]
IC50_uM 0.6665Inhibition of T. cruzi Tulahuen strain amastigotes in L-6 muscle cells Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2138-03_Inhibitor_Dose_DryPowder_Activity [AID651890, Type: confirmatory]
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6
[SID194160094]
IC50 0.67Antitrypanosomal activity against amastigote stage of Trypanosoma cruzi Tulahuen infected in rat L6 cells assessed as parasite growth inhibition after 96 hrs by beta-galactosidase reporter gene assay [AID1065122, Type: Literature]
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7
[SID85802191]
Intracellular Trypanosomes Measured in Cell-Based/Microorganism System Using Plate Reader - 2017-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651903, Type: screening]
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8
[SID194160094]
Solubility of the compound in phosphate buffer saline [AID1065123, Type: Literature]
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9
[SID194160094]
Fraction unbound in human plasma [AID1065108, Type: Literature]
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10
[SID194160094]
Metabolic stability in mouse microsomes assessed as compound remaining at 1 uM after 1 hr [AID1065120, Type: Literature]
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11
[SID194160094]
Plasma protein binding in human [AID1065121, Type: Literature]
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12
[SID134216474]
IC50_uM 0.873Inhibition of Plasmodium falcipirum NF54 Measured in Cell-Based System Using Plate Reader - 2138-11_Inhibitor_Dose_DryPowder_Activity [AID651889, Type: confirmatory]
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13
[SID134216474]
IC50_uM 1.018Inhibition of Trypanosoma brucei rhodesiense STIB900 Measured in Cell-Based System Using Plate Reader - 2138-05_Inhibitor_Dose_DryPowder_Activity [AID651894, Type: confirmatory]
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14
[SID134216474]
IC50_uM 47.6L-6 rat myocyte cell toxicity Measured in Cell-Based System Using Plate Reader - 2138-06_Inhibitor_Dose_DryPowder_Activity [AID651895, Type: confirmatory]
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15
[SID134216474]
IC50_uM 100Inhibition of L. donovani axenic amastigotes Measured in Cell-Based System Using Plate Reader - 2138-04_Inhibitor_Dose_DryPowder_Activity [AID651892, Type: confirmatory]
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16
[SID134216474]
High Content Cell-Based Imaging Primary HTS to Identify Small Molecules Involved in X-Chromosome Reactivation and Reprogramming Measured in Cell-Based System Using Imaging - 7015-01_Activator_SinglePoint_HTS_Activity_Set2 [AID743238, Type: screening]
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17
[SID134216474]
Inhibition of Alexa 488-Fibronectin deposition #on AH1F cell monolayers Measured in Cell-Based System Using Plate Reader - 7059-01_Inhibitor_SinglePoint_HTS_Activity [AID743247, Type: screening]
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18
[SID85802191]
SMM ID4 Measured in Biochemical System Using Small Molecule MicroArray - 2128-01_Other_SinglePoint_HTS_Activity [AID624137, Type: screening]Id4 [Homo sapiens] [gi:881546]
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19
[SID85802191]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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20
[SID85802191]
Turbidometric Biochemical Primary HTS to identify inhibitors of ERp5 Measured in Biochemical System Using Plate Reader - 7002-01_Inhibitor_SinglePoint_HTS_Activity [AID651711, Type: screening]Protein disulfide-isomerase A6 [gi:2501205]
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