Bookmark and Share
SureCN12474983 (CID 44493436) - Compound BioActivity Data
.
BioActivity Outcomes:
Probe(1)
 
 
Active(16)
 
 
Inactive(59)
 
 
Inconclusive(4)
 
 
Unspecified(2)
 
 
Top Targets:
HLH(2)
 
 
rad52(1)
 
 
YEATS(1)
 
 
TcdA TcdB por..(1)
 
 
STKc STK33(1)
 
 
BioAssay Types:
Screening(48)
 
 
 
 
Confirmatory(20)
 
 
 
 
Literature(8)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
IC50(12)
 
 
 
AC50(8)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 76    Data Row: 82   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID152146810]
Broad Institute Inhibition of T.cruzi replication in culture Inhibitor Probe Project [AID624280, Type: summary]
View
2
[SID134216491]
AC50_uM 0.000457Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_Dose_DryPowder_Activity [AID651845, Type: confirmatory]
View
3
[SID134216491]
Average IC50 (uM) 0.00066Inhibition of intracellular CAI/72 strain of Trypanosoma cruzi in bovine embryo skeletal muscle cells: high content imaging Measured in Cell-Based System Using Imaging - 2138-07_Inhibitor_SinglePoint_DryPowder_Activity [AID651885, Type: confirmatory]
View
4
[SID135701934]
AC50_uM 0.00442Inhibition of T.cruzi proliferation in culture Measured in Cell-Based System Using Plate Reader - 2138-01_Inhibitor_Dose_DryPowder_Activity_Set2 [AID652275, Type: confirmatory]
View
5
[SID134216491]
IC50_uM 0.0295Inhibition of T. cruzi Tulahuen strain amastigotes in L-6 muscle cells Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2138-03_Inhibitor_Dose_DryPowder_Activity [AID651890, Type: confirmatory]
View
6
[SID85800201]
AC50_uM 0.08Intracellular Trypanosomes Measured in Cell-Based/Microorganism System Using Plate Reader - 2017-01_Inhibitor_Dose_CherryPick_Activity_Set3 [AID651818, Type: confirmatory]
View
7
[SID85800201]
IC50_uM 1.02Inhibition of T. cruzi Tulahuen strain amastigotes in L-6 muscle cells Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2138-03_Inhibitor_Dose_CherryPick_Activity [AID651881, Type: confirmatory]
View
8
[SID85800201]
IC50_uM 1.02Inhibition of Plasmodium falcipirum NF54 Measured in Cell-Based System Using Plate Reader - 2138-11_Inhibitor_Dose_CherryPick_Activity [AID651888, Type: confirmatory]
View
9
[SID135701934]
IC50(uM) 13.2Inhibition of Trypanosoma cruzi Cruzain Measured in Biochemical System Using Plate Reader - 2138-09_Inhibitor_SinglePoint_DryPowder_Activity [AID651897, Type: confirmatory]cruzain [Trypanosoma cruzi] [gi:162048]
View
10
[SID85800201]
IC50_uM 14.4L-6 rat myocyte cell toxicity Measured in Cell-Based System Using Plate Reader - 2138-06_Inhibitor_Dose_CherryPick_Activity [AID651896, Type: confirmatory]
View
11
[SID85800201]
Intracellular Trypanosomes Measured in Cell-Based/Microorganism System Using Plate Reader - 2017-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651903, Type: screening]
View
12
[SID194148026]
Trypanocidal activity against Trypanosoma cruzi CA-I/72 infected in BESM cells assessed as parasite re-emergence at 740 nM treated for 20 days measured after 37 days [AID1065113, Type: Literature]
View
13
[SID135701934]
Cidal vs. static assay: inhibition of T. cruzi (CAI/72) after prolonged treatment and treatment withdrawal Measured in Cell-Based System Using Imaging - 2138-08_Inhibitor_SinglePoint_DryPowder_Activity_Set2 [AID651869, Type: other]
View
14
[SID135701934]
Cidal vs. static assay: inhibition of T. cruzi (CAI/72) after prolonged treatment and treatment withdrawal Measured in Cell-Based System Using Imaging - 2138-08_Inhibitor_SinglePoint_DryPowder_Activity [AID651877, Type: other]
View
15
[SID194148026]
Trypanocidal activity against Trypanosoma cruzi CA-I/72 infected in BESM cells assessed as parasite re-emergence at 740 nM measured over 20 days of drug treatment [AID1065114, Type: Literature]
View
16
[SID194148026]
Trypanocidal activity against Trypanosoma cruzi CA-I/72 infected in BESM cells assessed as parasite re-emergence at 40 nM treated for 29 days measured after 36 days [AID1065117, Type: Literature]
View
17
[SID194148026]
Trypanocidal activity against Trypanosoma cruzi CA-I/72 infected in BESM cells assessed as parasite re-emergence at 40 nM measured over 29 days of drug treatment [AID1065118, Type: Literature]
View
18
[SID194148026]
Metabolic stability in mouse microsomes assessed as compound remaining at 1 uM after 1 hr [AID1065120, Type: Literature]
View
19
[SID194148026]
Plasma protein binding in human [AID1065121, Type: Literature]
View
20
[SID134216491]
IC50_uM 0.504Inhibition of Plasmodium falcipirum NF54 Measured in Cell-Based System Using Plate Reader - 2138-11_Inhibitor_Dose_DryPowder_Activity [AID651889, Type: confirmatory]
View