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BioActivity Data for Compound alpha-cyclodextrin (CID 444913)

BioActivity Outcomes:
Active(11)
 
 
Inactive(908)
 
 
Inconclusive(27)
 
 
Unspecified(137)
 
 
Top Targets:
7tm 4(55)
 
 
 
NR LBD PPAR(28)
 
 
 
NR LBD ER(27)
 
 
 
 
 
NR LBD AR(26)
 
 
 
 
NR LBD GR(17)
 
 
 
 
BioAssay Types:
Confirmatory(668)
 
 
 
 
 
Screening(232)
 
 
Literature(75)
 
 
 
 
Summary(69)
 
 
 
 
BioAssay Categories:
In vitro(133)
 
 
Biochemical(199)
 
 
 
Toxicity(59)
 
 
 
 
Cell-based(149)
 
 
 
Organism-base..(7)
 
 
BioActivity Types:
Potency(536)
 
 
 
 
 
IC50(141)
 
 
 
 
Kd(6)
 
 
EC50(4)
 
 
AC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 752    Data Row: 1083   Total Pages: 55   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID170481960]
Kd 0.73Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of CycloMALTODEXTRIN-Binding Protein Complexed With Alpha-Cyclodextrin [gi:226192594]
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2
[SID170481960]
Kd 0.73Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Crystal Structure Of CycloMALTODEXTRIN-Binding Protein Complexed With Alpha-Cyclodextrin [gi:226192594]
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3
[SID17389189]
Potency 11.2202qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID144204566]
Potency-Replicate_1 23.7101qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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5
[SID144210622]
Ratio Potency (uM) 27.7931qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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6
[SID208012693]
Kd 86.96Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
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7
[SID208012693]
Kd 86.96Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]
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8
[SID87557669]
Kd 89Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain B, B. Thetaiotaomicron Susd With Alpha-Cyclodextrin [gi:171849119]
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9
[SID87557669]
Kd 89Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain B, B. Thetaiotaomicron Susd With Alpha-Cyclodextrin [gi:171849119]
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10
[SID170484544]
IC50 19000Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain B, Glge Isoform 1 From Streptomyces Coelicolor With Alpha-Cyclodextrin Bound [gi:346652107]
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11
[SID170484544]
IC50 19000Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain B, Glge Isoform 1 From Streptomyces Coelicolor With Alpha-Cyclodextrin Bound [gi:346652107]
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12
[SID104247004]
DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) [AID625179, Type: other]Protein kinase C alpha type [gi:317373571]
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13
[SID104247004]
DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625246, Type: other]Cytochrome P450 2A6 [gi:308153612]
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14
[SID104247004]
IC50 DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: confirmatory]Delta-type opioid receptor [gi:311033488]
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15
[SID104247004]
IC50 DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) [AID625167, Type: confirmatory]cGMP-specific 3',5'-cyclic phosphodiesterase [gi:317373261]
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16
[SID104247004]
IC50 DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]Prostaglandin G/H synthase 1 [gi:317373262]
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17
[SID104247004]
IC50 DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) [AID625229, Type: confirmatory]Thromboxane-A synthase [gi:254763392]
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18
[SID104247004]
IC50 DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625178, Type: confirmatory]Matrix metalloproteinase-9 [gi:269849668]
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19
[SID104247004]
IC50 DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: confirmatory]Beta-2 adrenergic receptor [gi:296439450]
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20
[SID104247004]
IC50 DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) [AID625227, Type: confirmatory]Substance-K receptor [gi:229462950]
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