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Arachidonic Acid (CID 444899) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(50)
 
 
Inactive(273)
 
 
Inconclusive(37)
 
 
Unspecified(42)
 
 
Top Targets:
PLDc mTdp1 2(10)
 
 
 
 
NR LBD TR(8)
 
 
Tubulin-bindi..(8)
 
 
 
 
7TM GPCR Srx(7)
 
 
p450(7)
 
 
 
 
 
BioAssay Types:
Confirmatory(239)
 
 
 
 
Screening(92)
 
 
 
Literature(66)
 
 
 
 
BioActivity Types:
Potency(220)
 
 
 
 
IC50(27)
 
 
 
 
Kd(2)
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 257    Data Row: 402   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103178961]
IC50 0.0047Concentration required to inhibit production of LTC4 from THP-1 cells stimulated with A-23187 [AID209196, Type: Literature]
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2
[SID26747902]
Potency 0.0794qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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3
[SID103178961]
IC50 0.18Concentration required to inhibit production of PGE-2 from THP-1 cells stimulated with A-23187 [AID209197, Type: Literature]
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4
[SID103178961]
Kd 0.18Binding affinity against Adipocyte lipid binding protein [AID32788, Type: Literature]
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5
[SID103178961]
IC50 0.3Inhibition of mPGES1 [AID405533, Type: Literature]
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6
[SID26753719]
Potency 0.3162qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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7
[SID103178961]
IC50 0.94Concentration required to inhibit production of LTB4 from whole blood stimulated with A-23187 [AID223075, Type: Literature]
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8
[SID103178961]
Km 1Activity of COX2 [AID336480, Type: Literature]
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9
[SID26753719]
Potency 1.9953qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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10
[SID26753719]
Potency 1.9953qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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11
[SID26747902]
Potency 2.2387qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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12
[SID26747902]
Potency 2.8184qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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13
[SID26747902]
Potency 3.9811qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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14
[SID26747902]
Potency 3.9811qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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15
[SID26747902]
Potency 5.6234Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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16
[SID26753719]
Potency 7.9433Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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17
[SID26753719]
Potency 7.9433qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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18
[SID103178961]
Km 8.8Activity of bovine seminal microsomal COX1 [AID399408, Type: Literature]Prostaglandin G/H synthase 1 [gi:166897622]
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19
[SID103178961]
Km 9.7Activity of sheep placental cotyledons COX2 [AID399409, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
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20
[SID103178961]
IC50 10Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of delipidated fetal calf serum medium by RT-PCR [AID330323, Type: Literature]
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21
[SID26747902]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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22
[SID26747902]
Potency 12.5893qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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23
[SID26753719]
Potency 12.5893qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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24
[SID103178961]
Km 15Activity of soybean lipooxygenase 1 [AID409935, Type: Literature]
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25
[SID26747902]
Potency 15.8489qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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26
[SID26747902]
Potency 15.8489qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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27
[SID57261284]
Potency 15.8489qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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28
[SID57261284]
Potency 17.7828qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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29
[SID103178961]
EC50 22.1Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 72 hrs by luciferase reporter assay [AID323922, Type: Literature]
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30
[SID26747902]
Potency 22.3872qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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31
[SID26747902]
Potency 22.3872qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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32
[SID26753719]
Potency 23.715qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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33
[SID26747902]
Potency 25.1189qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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34
[SID26753719]
Potency 28.1838qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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35
[SID26753719]
Potency 28.1838qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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36
[SID103178961]
IC50 28.2Inhibition of aromatase in human placental microsomes by radiometric method [AID376617, Type: Literature]Aromatase [gi:117293]
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37
[SID26753719]
Potency 29.8554qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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38
[SID103178961]
IC50 40Concentration required to inhibit production of arachidonic acid from THP-1 cells stimulated with A-23187 [AID209198, Type: Literature]
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39
[SID26753719]
Potency 50.1187Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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40
[SID26753719]
Potency 63.0957qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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41
[SID46392023]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Human Serum Albumin Complexed With Cis-5,8,11,14- Eicosatetraenoic Acid (Arachidonic Acid) [gi:18158775]
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42
[SID57261284]
Fluorescence-based primary cell-based high throughput screening assay to identify potentiators of Oxytocin Receptor (OXTR) [AID2445, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
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43
[SID57261284]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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44
[SID46393430]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Schistosoma Mansoni Fatty Acid Binding Protein In Complex With Arachidonic Acid [gi:55670478]
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45
[SID57261284]
QFRET-based counterscreen for PFM18AAP inhibitors: biochemical high throughput screening assay to identify inhibitors of the Cathepsin L proteinase (CTSL1). [AID1906, Type: screening]cathepsin L1 [Homo sapiens] [gi:55958172]
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46
[SID103178961]
Reversal of inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of delipidated fetal calf serum medium assessed as malondialdehyde level at 0.1 mM in presence of vitamin E [AID330318, Type: Literature]
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47
[SID103178961]
Binding affinity to enterotoxigenic Escherichia coli 12566 heat-labile enterotoxin assessed as inhibition of heat-labile enterotoxin binding to ganglioside GM1 receptor [AID423137, Type: Literature]
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48
[SID103178961]
Inhibition of hepatitis C virus replication in Huh7-K2040 in presence of delipidated fetal calf serum medium assessed as increase of malondialdehyde at 0.1 mM after 12 to 24 hrs [AID330330, Type: Literature]
View
49
[SID57261284]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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50
[SID46391417]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Adipocyte Lipid Binding Protein Complexed With Arachidonic Acid: X-Ray Crystallographic And Titration Calorimetry Studies [gi:157829813]
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