Bookmark and Share
Tretinoin (CID 444795) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(555)
 
 
Inactive(1494)
 
 
Inconclusive(227)
 
 
Unspecified(937)
 
 
Top Targets:
NR LBD RAR(72)
 
 
 
 
 
7TM GPCR Srx(47)
 
 
 
 
NR LBD PPAR(43)
 
 
 
 
7TM GPCR Srsx(40)
 
 
 
 
NR LBD RXR li..(37)
 
 
 
 
BioAssay Types:
Confirmatory(860)
 
 
 
 
 
Literature(705)
 
 
 
 
 
Screening(684)
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
IC50(804)
 
 
 
 
Potency(749)
 
 
 
 
 
EC50(94)
 
 
 
 
Kd(59)
 
 
 
Ki(25)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2531    Data Row: 3213   Total Pages: 65   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165713]
ED50 9e-06Dose for reversal of keratinization in epithelium of 50% of retinoid-deficient hamster tracheas in organ culture in experiment B [AID84704, Type: Literature]
View
2
[SID103165713]
ED50 1e-05Dose for reversal of keratinization in epithelium of 50% of retinoid-deficient hamster tracheas in organ culture in experiment D [AID84706, Type: Literature]
View
3
[SID103165713]
ID50 1e-05Inhibitory dose against tracheal organ culture reversal of keratinization [AID210769, Type: Literature]
View
4
[SID103165713]
IC50 1e-05Reversal of keratinization in vitamin A-deficient hamster trachea after 10 days by TOC assay [AID288572, Type: Literature]
View
5
[SID103165713]
ED50 2e-05Dose for reversal of keratinization in epithelium of 50% of retinoid-deficient hamster tracheas in organ culture in experiment A [AID84703, Type: Literature]
View
6
[SID103165713]
ED50 3e-05Reversal of keratinization in vitamin A deficient hamster trachea culture [AID84861, Type: Literature]
View
7
[SID103165713]
ID50 4e-05Inhibitory effect of compound on the induction of ornithine decarboxylase in CD-1 mouse. [AID150874, Type: Literature]
View
8
[SID103165713]
Ki 4e-05Agonistic activity towards retinoic acid receptor-gamma [AID198732, Type: Literature]
View
9
[SID103165713]
ED50 0.0001Dose for reversal of keratinization in epithelium of 50% of retinoid-deficient hamster tracheas in organ culture in experiment C [AID84705, Type: Literature]
View
10
[SID103165713]
IC50 0.0001Induction of terminal differentiation in mouse F9 cells assessed by measuring secreted plasminogen activator activity after 3 days [AID288573, Type: Literature]
View
11
[SID103165713]
Ki 0.0001Binding affinity towards human Retinoic acid receptor alpha [AID197887, Type: other]Retinoic acid receptor alpha [gi:133483]
View
12
[SID103165713]
ED50 0.0001Ability to displace 3 uM retinoid and [3H]all-trans-retinoic acid in F9 embryonal carcinoma cells using F9 Plasminogen Activator releasing assay [AID68786, Type: Literature]
View
13
[SID103165713]
ED50 0.0001Ability to induce differentiation of mouse F9 embryonal carcinoma cells. [AID68788, Type: Literature]
View
14
[SID103165713]
ID50 0.00012Compound was evaluated for the ability to inhibit the phorbol ester induced increase of mouse epidermal ornithine decarboxylase (ODC) activity by 50% when administered topically using ODC assay. [AID151013, Type: Literature]Ornithine decarboxylase [gi:341940428]
View
15
[SID103165713]
Kd 0.0002Dissociation constant for Retinoic acid receptor gamma [AID254257, Type: Literature]Retinoic acid receptor gamma [gi:133498]
View
16
[SID103165713]
EC50 0.0002Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay [AID392142, Type: Literature]Retinoic acid receptor gamma [gi:133498]
View
17
[SID103165713]
Kd 0.0003Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assay [AID198728, Type: Literature]Retinoic acid receptor gamma [gi:133498]
View
18
[SID103165713]
Ki 0.0004Binding affinity towards cRAR-beta-2 receptor by displacing 1.1 nM 3[H]-9-cis-RA [AID220313, Type: other]
View
19
[SID103165713]
Kd 0.0004Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assay [AID198215, Type: Literature]Retinoic acid receptor beta [gi:17380507]
View
20
[SID103165713]
Ki 0.0004Binding affinity for retinoic acid receptor RAR alpha [AID35839, Type: Literature]
View
21
[SID103165713]
Kd 0.0004Inhibition of [3H]ATRA binding to murine Cytoplasmic retinoic acid binding protein (CRABP) type 1 [AID55252, Type: Literature]Cellular retinoic acid-binding protein 1 [gi:51702797]
View
22
[SID103165713]
Kd 0.0004Binding affinity for mouse Cytoplasmic retinoic acid binding protein type 1 [AID55253, Type: Literature]Cellular retinoic acid-binding protein 1 [gi:51702797]
View
23
[SID103165713]
Ki 0.0005Binding affinity for retinoic acid receptor RAR beta [AID41913, Type: Literature]
View
24
[SID103165713]
Ki 0.0005Binding affinity towards cRARbeta2 receptor by displacing 0.82 nM 3[H]all-trans-RA [AID220312, Type: other]
View
25
[SID103165713]
EC50 0.0005Transcriptional activation of Retinoic acid receptor RAR gamma [AID198904, Type: Literature]
View
26
[SID103165713]
IC50 0.0005Inhibition of [3H]ATRA-Hl60 binding to Retinoic acid receptor gamma [AID199044, Type: Literature]
View
27
[SID103165713]
EC50 0.0005Transcriptional activation of retinoic acid receptor RAR gamma [AID198896, Type: other]
View
28
[SID103165713]
EC50 0.0005Transcriptional activation for RAR gamma receptor [AID166213, Type: other]
View
29
[SID103165713]
EC50 0.0005Transcriptional activation of Retinoic acid receptor RAR gamma [AID198713, Type: Literature]Retinoic acid receptor gamma [gi:133498]
View
30
[SID103165713]
Ki 0.0005Inhibition of [3H]RA to binding Retinoic acid receptor RAR gamma [AID198740, Type: other]Retinoic acid receptor gamma [gi:133498]
View
31
[SID103165713]
Ki 0.0006Binding affinity towards human Retinoic acid receptor gamma [AID198742, Type: other]Retinoic acid receptor gamma [gi:133498]
View
32
[SID103165713]
IC50 0.00062Binding affinity against Retinoic acid receptor gamma [AID199045, Type: Literature]
View
33
[SID103165713]
IC50 0.00063The concentration required to inhibit the binding of [3H]ATRA to retinoic acid receptor in human promyelocytic leukemia cells [AID199330, Type: Literature]
View
34
[SID103165713]
IC50 0.00065Compound was evaluated for its inhibition of LPS-induced mouse B-lymphocyte proliferation. The result is expressed as relative IC50 i.e., IC50 of compound / All Trans Retinoic Acid IC50 [AID38341, Type: Literature]
View
35
[SID103165713]
EC50 0.0007Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma [AID198899, Type: Literature]
View
36
[SID103165713]
EC50 0.0007Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay [AID198903, Type: other]
View
37
[SID103165713]
Ki 0.0007Binding affinity against Retinoic acid receptor gamma [AID199055, Type: Literature]Retinoic acid receptor gamma [gi:133498]
View
38
[SID103165713]
IC50 0.00078Inhibition of [3H]ATRA-Hl60 binding to Retinoic acid receptor alpha [AID198043, Type: Literature]
View
39
[SID103165713]
IC50 0.00089Binding affinity for Retinoic acid receptor alpha [AID198044, Type: Literature]
View
40
[SID103165713]
IC50 0.0009Inhibition of [3H]-ATRA-Hl60 binding to Retinoic acid receptor beta [AID198533, Type: Literature]
View
41
[SID103165713]
IC50 0.00094Binding affinity for Retinoic acid receptor beta [AID198534, Type: Literature]
View
42
[SID103165713]
EC50 0.001Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta [AID198378, Type: Literature]
View
43
[SID103165713]
EC50 0.001Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay [AID198382, Type: other]
View
44
[SID103165713]
Ki 0.0014Binding affinity for retinoic acid receptor RAR gamma [AID73356, Type: Literature]
View
45
[SID103165713]
EC50 0.0015Transcriptional activation for RAR beta receptor [AID166209, Type: other]
View
46
[SID103165713]
EC50 0.0015Transcriptional activation of Retinoic acid receptor RAR beta [AID198383, Type: Literature]
View
47
[SID103165713]
EC50 0.0015Transcriptional activation of retinoic acid receptor RAR beta [AID198374, Type: other]
View
48
[SID103165713]
EC50 0.0015Transcriptional activation of Retinoic acid receptor RAR beta [AID198201, Type: Literature]Retinoic acid receptor beta [gi:17380507]
View
49
[SID103165713]
ED50 0.0015Ability to displace [3H]all-trans-retinoic acid from F9 embryonal carcinoma cells, was assessed in a F9 laminin release assay [AID68787, Type: Literature]
View
50
[SID103165713]
IC50 0.0017Inhibition of ER-negative human breast cancer cell SK-BR-3 proliferation [AID201645, Type: Literature]
View