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Tretinoin (CID 444795) - Compound BioActivity Data
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BioActivity Outcomes:
Active(554)
 
 
Inactive(1529)
 
 
Inconclusive(228)
 
 
Unspecified(1125)
 
 
Top Targets:
NR LBD RAR(77)
 
 
 
 
 
7TM GPCR Srx(46)
 
 
 
 
NR LBD RXR li..(44)
 
 
 
 
 
NR LBD PPAR(43)
 
 
 
 
7TM GPCR Srsx(40)
 
 
 
 
BioAssay Types:
Confirmatory(1589)
 
 
 
 
 
Literature(767)
 
 
 
 
 
Screening(687)
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
IC50(805)
 
 
 
 
Potency(752)
 
 
 
 
 
EC50(95)
 
 
 
 
Kd(59)
 
 
 
Ki(27)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2739    Data Row: 3436   Total Pages: 172   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165713]
ED50 9e-06Dose for reversal of keratinization in epithelium of 50% of retinoid-deficient hamster tracheas in organ culture in experiment B [AID84704, Type: Literature]
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2
[SID103165713]
ED50 1e-05Dose for reversal of keratinization in epithelium of 50% of retinoid-deficient hamster tracheas in organ culture in experiment D [AID84706, Type: Literature]
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3
[SID103165713]
ID50 1e-05Inhibitory dose against tracheal organ culture reversal of keratinization [AID210769, Type: Literature]
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4
[SID103165713]
IC50 1e-05Reversal of keratinization in vitamin A-deficient hamster trachea after 10 days by TOC assay [AID288572, Type: Literature]
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5
[SID103165713]
ED50 2e-05Dose for reversal of keratinization in epithelium of 50% of retinoid-deficient hamster tracheas in organ culture in experiment A [AID84703, Type: Literature]
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6
[SID103165713]
ED50 3e-05Reversal of keratinization in vitamin A deficient hamster trachea culture [AID84861, Type: Literature]
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7
[SID103165713]
ID50 4e-05Inhibitory effect of compound on the induction of ornithine decarboxylase in CD-1 mouse. [AID150874, Type: Literature]
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8
[SID103165713]
Ki 4e-05Agonistic activity towards retinoic acid receptor-gamma [AID198732, Type: Literature]
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9
[SID103165713]
ED50 0.0001Dose for reversal of keratinization in epithelium of 50% of retinoid-deficient hamster tracheas in organ culture in experiment C [AID84705, Type: Literature]
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10
[SID103165713]
ED50 0.0001Ability to displace 3 uM retinoid and [3H]all-trans-retinoic acid in F9 embryonal carcinoma cells using F9 Plasminogen Activator releasing assay [AID68786, Type: Literature]
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11
[SID103165713]
ED50 0.0001Ability to induce differentiation of mouse F9 embryonal carcinoma cells. [AID68788, Type: Literature]
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12
[SID103165713]
IC50 0.0001Induction of terminal differentiation in mouse F9 cells assessed by measuring secreted plasminogen activator activity after 3 days [AID288573, Type: Literature]
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13
[SID103165713]
Ki 0.0001Binding affinity towards human Retinoic acid receptor alpha [AID197887, Type: confirmatory]Retinoic acid receptor alpha [gi:133483]
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14
[SID103165713]
ID50 0.00012Compound was evaluated for the ability to inhibit the phorbol ester induced increase of mouse epidermal ornithine decarboxylase (ODC) activity by 50% when administered topically using ODC assay. [AID151013, Type: Literature]Ornithine decarboxylase [gi:341940428]
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15
[SID103165713]
Kd 0.0002Dissociation constant for Retinoic acid receptor gamma [AID254257, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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16
[SID103165713]
EC50 0.0002Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay [AID392142, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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17
[SID103165713]
Kd 0.0003Apparent binding constant against Retinoic acid receptor gamma in HeLa cell GAl-4 transactivation assay [AID198728, Type: Literature]Retinoic acid receptor gamma [gi:133498]
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18
[SID103165713]
Ki 0.0004Binding affinity towards cRAR-beta-2 receptor by displacing 1.1 nM 3[H]-9-cis-RA [AID220313, Type: confirmatory]
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19
[SID103165713]
Ki 0.0004Binding affinity for retinoic acid receptor RAR alpha [AID35839, Type: Literature]
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20
[SID103165713]
Kd 0.0004Apparent binding constant for Retinoic acid receptor beta in HeLa cellGAL-4 transactivation assay [AID198215, Type: Literature]Retinoic acid receptor beta [gi:17380507]
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