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trichostatin A (CID 444732) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(534)
 
 
Inactive(122)
 
 
Inconclusive(12)
 
 
Unspecified(73)
 
 
Top Targets:
HDAC1(51)
 
 
 
HDAC4(31)
 
 
HDAC6-dom1(29)
 
 
HDAC3(25)
 
 
HDAC8(21)
 
 
BioAssay Types:
Literature(633)
 
 
 
 
 
Confirmatory(90)
 
 
 
 
 
Screening(6)
 
 
BioActivity Types:
IC50(430)
 
 
 
 
Potency(81)
 
 
 
 
EC50(12)
 
 
 
Ki(10)
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 552    Data Row: 741   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174338]
IC50 0.00015Inhibition of HDAC1 [AID488273, Type: Literature]
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2
[SID103174338]
Ki 0.0002Inhibition of human HDAC1 [AID496801, Type: Literature]Histone deacetylase 1 [gi:2498443]
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3
[SID103174338]
IC50 0.0004Inhibition of maize HD1B [AID273168, Type: Literature]Histone deacetylase [gi:75267996]
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4
[SID103174338]
IC50 0.0004Inhibition of maize histone deacetylase 1B [AID384316, Type: Literature]Histone deacetylase [gi:75267996]
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5
[SID103174338]
IC50 0.0004Inhibitory activity against maize Histone deacetylase 1-B [AID90672, Type: Literature]
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6
[SID103174338]
IC50 0.0004Inhibitory concentration against maize histone deacetylase 1-B (class I HDAC) [AID241538, Type: Literature]
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7
[SID103174338]
IC50 0.0004Inhibition of human HDAC6 [AID417649, Type: Literature]Histone deacetylase 6 [gi:205371758]
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8
[SID103174338]
IC50 0.00042Inhibition of human HDAC6 by fluorimetric assay [AID541652, Type: Literature]Histone deacetylase 6 [gi:205371758]
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9
[SID103174338]
Ki 0.0005Inhibition of human HDAC3 [AID496803, Type: Literature]Histone deacetylase 3 [gi:3334210]
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10
[SID103174338]
IC50 0.0006Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells [AID414980, Type: Literature]Histone deacetylase [gi:74849912]
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11
[SID103174338]
IC50 0.0006Inhibition of HDAC3 [AID488275, Type: Literature]
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12
[SID103174338]
Ki 0.00065Inhibition of human HDAC2 [AID496802, Type: Literature]Histone deacetylase 2 [gi:68068066]
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13
[SID96099520]
AC50_uM 0.00075Fluorescence Biochemical Dose Confirmation to Identify Inhibitors of Yeast HDACs [AID463208, Type: confirmatory]unnamed protein product [Saccharomyces cerevisiae] [gi:1360328]
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14
[SID103174338]
IC50 0.0008Inhibition of maize histone deacetylase 1A [AID384317, Type: Literature]
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15
[SID103174338]
IC50 0.0008Inhibition of HDAC6 by in vitro deacetylation assay [AID524999, Type: Literature]
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16
[SID103174338]
IC50 0.0008Inhibition of maize HD1A [AID273167, Type: Literature]
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17
[SID103174338]
IC50 0.0008Inhibitory concentration against maize histone deacetylase 1-A (class IIa HDAC) [AID241537, Type: Literature]
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18
[SID103174338]
IC50 0.0008Inhibitory activity afgainst maize Histone deacetylase 1-A [AID90671, Type: Literature]
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19
[SID103174338]
IC50 0.001Inhibition of HDAC6 after 17 hrs [AID366644, Type: Literature]
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20
[SID103174338]
IC50 0.001Inhibition of HDAC2 [AID488274, Type: Literature]
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21
[SID103174338]
IC50 0.001Inhibition of HDAC from RT extract [AID420329, Type: Literature]
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22
[SID103174338]
IC50 0.001Inhibition of HDAC6 [AID408885, Type: Literature]
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23
[SID103174338]
IC50 0.001Inhibition of HDAC6 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465154, Type: Literature]
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24
[SID103174338]
Ki 0.001Inhibition of human HDAC6 [AID496806, Type: Literature]Histone deacetylase 6 [gi:205371758]
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25
[SID103174338]
IC50 0.0011Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay [AID659293, Type: Literature]Histone deacetylase 2 [gi:68068066]
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26
[SID103174338]
IC50 0.0012Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate [AID708215, Type: Literature]Histone deacetylase 6 [gi:205371758]
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27
[SID103174338]
IC50 0.0013Antiproliferative activity against HCT116 cells [AID274171, Type: Literature]
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28
[SID103174338]
IC50 0.00138Inhibition of HDAC8 after 17 hrs [AID366643, Type: Literature]
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29
[SID103174338]
IC50 0.00144Inhibitory concentration against partially purified mouse histone deacetylase (HDAC) [AID90519, Type: Literature]
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30
[SID103174338]
IC50 0.0015Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)benzoic acid from HDAC in human HeLa nuclear cell extract by fluorescence polarization assay [AID331898, Type: Literature]
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31
[SID103174338]
IC50 0.0015Inhibition of human HDAC6 by fluorescence assay [AID723462, Type: Literature]Histone deacetylase 6 [gi:205371758]
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32
[SID103174338]
IC50 0.0018Inhibition of mouse HDAC1 [AID273173, Type: Literature]Histone deacetylase 1 [gi:2498444]
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33
[SID103174338]
IC50 0.0018Inhibition of mouse liver HDAC1 [AID316880, Type: Literature]Histone deacetylase 1 [gi:2498444]
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34
[SID103174338]
IC50 0.0019Inhibition of human HDAC1 expressed in 293T cells [AID309967, Type: Literature]Histone deacetylase 1 [gi:2498443]
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35
[SID103174338]
IC50 0.002In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cells [AID90675, Type: Literature]Histone deacetylase 1 [gi:2498444]
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36
[SID103174338]
IC50 0.002Inhibition of mouse HDAC1 [AID90681, Type: Literature]Histone deacetylase 1 [gi:2498444]
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37
[SID103174338]
IC50 0.002Inhibition of HDAC3 after 17 hrs [AID366642, Type: Literature]
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38
[SID103174338]
IC50 0.002Inhibition of HDAC3 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs [AID465151, Type: Literature]
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39
[SID103174338]
IC50 0.002Inhibition of HDAC3 [AID408882, Type: Literature]
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40
[SID103174338]
IC50 0.002Inhibition of human HDAC4 expressed in 293T cells [AID309968, Type: Literature]Histone deacetylase 4 [gi:259016348]
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41
[SID103174338]
IC50 0.0023Inhibition of human HDAC1 in presence of dithiothreitol by HDAC fluorescent assay [AID659292, Type: Literature]Histone deacetylase 1 [gi:2498443]
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42
[SID103174338]
IC50 0.00231Inhibition of human recombinant HDAC6 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 mins [AID628433, Type: Literature]Histone deacetylase 6 [gi:205371758]
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43
[SID103174338]
IC50 0.0028Inhibition of mouse HDAC6 expressed in 293T cells [AID309969, Type: Literature]Histone deacetylase 6 [gi:341941079]
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44
[SID103174338]
IC50 0.003Inhibition of human HDAC1 using rhodamine as substrate after 1 hrs by fluorescence assay [AID611683, Type: Literature]Histone deacetylase 1 [gi:2498443]
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45
[SID103174338]
IC50 0.003Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assay [AID608776, Type: Literature]
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46
[SID103174338]
IC50 0.003Inhibition of in vitro enzyme activity measured in a highly purified maize Histone deacetylase 2 preparation [AID90682, Type: Literature]HD2 type histone deacetylase HDA106 [gi:75165534]
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47
[SID103174338]
IC50 0.003Inhibitory concentration against maize Histone deacetylase 2 [AID90687, Type: Literature]HD2 type histone deacetylase HDA106 [gi:75165534]
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48
[SID103174338]
IC50 0.003Inhibition of maize Histone deacetylase 2 (HD-2) activity [AID90695, Type: Literature]HD2 type histone deacetylase HDA106 [gi:75165534]
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49
[SID103174338]
IC50 0.003Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorimetric assay [AID447991, Type: Literature]
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50
[SID103174338]
IC50 0.003Inhibition of HDAC in human HeLa cell cytosolic extract after 30 mins by fluorimetric assay [AID447992, Type: Literature]
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