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Ergosterol (CID 444679) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(16)
 
 
Inconclusive(1)
 
 
Unspecified(8)
 
 
Top Targets:
NOS oxygenase..(1)
 
 
GT1 Gtf like(1)
 
 
BioAssay Types:
Literature(19)
 
 
 
 
 
BioActivity Types:
IC50(8)
 
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 29    Data Row: 29   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104248738]
IC50 27.9Antiinflammatory activity in human PMNC cells assessed as inhibition of fMLP-induced NOX-dependent ROS production up to 50 uM [AID550017, Type: Literature]
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2
[SID104248738]
IC50 27.9Inhibition of NOX in fMLP-induced PMN cells assessed as NO production [AID552869, Type: Literature]
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3
[SID104248738]
IC50 30.6Inhibition of iNOS in mouse BV2 microglial cells assessed as NO production [AID552870, Type: Literature]Nitric oxide synthase, inducible [gi:266649]
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4
[SID104248738]
IC50 30.6Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method [AID550015, Type: Literature]
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5
[SID104248738]
Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as growth inhibition at 2 mg/mL after 24 hr by disk diffusion method [AID1105919, Type: other]
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6
[SID104248738]
Inhibition of TNFalpha-induced NF-kappaB activity (unknown origin) expressed in HeLa cells cotreated with compound and 10 ng/ml TNF-alpha for 24 hr by reporter gene assay [AID1095935, Type: other]
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7
[SID104248738]
Antibacterial activity against Pseudomonas aeruginosa MTCC 2642 assessed as growth inhibition at 2 mg/mL after 24 hr by disk diffusion method [AID1105915, Type: other]
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8
[SID104248738]
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells assessed as cell viability at 50 uM after 24 hrs by MTT assay [AID736896, Type: Literature]
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9
[SID104248738]
IC50 Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 50 uM after 24 hrs by MTT assay [AID736897, Type: Literature]
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10
[SID104248738]
Cytotoxicity against Homo sapiens (human) HeLa cells after 48 hr by MTT assay [AID1095934, Type: other]
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11
[SID104248738]
Antibacterial activity against Legionella pneumophila Corby by microtiter plate assay [AID592502, Type: Literature]
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12
[SID104248738]
Specific activity of expressed human recombinant UGT1A1 [AID624606, Type: Literature]UDP-glucuronosyltransferase 1-1 [gi:136729]
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13
[SID104248738]
Antibacterial activity against Escherichia coli K-12 by microtiter plate assay [AID592503, Type: Literature]
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14
[SID104248738]
Antibacterial activity against Bacillus megaterium by microtiter plate assay [AID592504, Type: Literature]
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15
[SID104248738]
Antifungal activity against Candida albicans SC5314 at 100 ug/mL after 16 hrs by broth microdilution method [AID606223, Type: Literature]
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16
[SID104248738]
Increase in ABC1 mRNA expression in Candida krusei B2402 after 60 mins by hot-phenol extraction based Northern blotting [AID554939, Type: Literature]
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17
[SID104248738]
Antifungal activity against Microbotryum violaceum assessed as zone of inhibition measured as radius at 50 ug by agar diffusion assay [AID592501, Type: Literature]
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18
[SID104248738]
IC50 Inhibition of ATP sythesis in freshly lysed Spinacia oleracea (spinach) chloroplasts [AID1090673, Type: Literature]
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19
[SID104248738]
Antibacterial activity against Escherichia coli MTCC 82 assessed as growth inhibition at 2 mg/mL after 24 hr by disk diffusion method [AID1105917, Type: other]
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20
[SID104248738]
Antifungal activity against Candida albicans SC5314 at 100 ug/mL after 16 hrs by CLSI M-27A broth microdilution method in presence of 0.004 ug/mL ketoconazole relative to compound alone [AID606225, Type: Literature]
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