cinnamic acid (CID 444539) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(117)
 
 
Unspecified(35)
 
 
Top Targets:
PTKc Syk(6)
 
 
 
 
Aldo ket red(2)
 
 
DUF3652(2)
 
 
Geminin(2)
 
 
Tyrosinase(2)
 
 
BioAssay Types:
Literature(109)
 
 
 
 
Confirmatory(34)
 
 
Screening(3)
 
 
BioActivity Types:
Potency(32)
 
 
IC50(17)
 
 
 
 
EC50(1)
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 94    Data Row: 161   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103198631]
IC50 0.18Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhage incubated with compound for 10 mins measured after 24 hrs [AID592088, Type: Literature]
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2
[SID103198631]
Ki 4.9Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting [AID594381, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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3
[SID103198631]
IC50 43.4Inhibition of N-terminal His-tagged Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) using [3H]acetyl-coA after 25 mins by liquid scintillation counting [AID610072, Type: Literature]3-oxoacyl-[acyl-carrier-protein] synthase III; acetylCoA ACP transacylase [Escherichia coli] [gi:412969007]
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4
[SID103198631]
 Inhibition of spleen tyrosine kinase in rat RBL-2H3 cells assessed as inhibition of IgE-induced increase of intracellular calcium level at 50 uM after 30 mins by FLIPR assay [AID499619, Type: Literature]Tyrosine-protein kinase SYK [gi:3219819]
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5
[SID103198631]
 Inhibition of spleen tyrosine kinase in rat RBL-2H3 cells assessed as inhibition of IgE-induced increase of ROS level at 50 uM after 30 mins by FLIPR assay [AID499620, Type: Literature]Tyrosine-protein kinase SYK [gi:3219819]
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6
[SID103198631]
 Inhibition of spleen tyrosine kinase in rat RBL-2H3 cells assessed as inhibition of IgE-induced upregulation of phospholipase Cgamma1 level at 50 uM after 30 mins by Western blotting [AID499621, Type: Literature]Tyrosine-protein kinase SYK [gi:3219819]
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7
[SID103198631]
 Inhibition of spleen tyrosine kinase in rat RBL-2H3 cells assessed as inhibition of IgE-induced upregulation of phospholipase 2 level at 50 uM after 30 mins by Western blotting [AID499622, Type: Literature]Tyrosine-protein kinase SYK [gi:3219819]
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8
[SID103198631]
 Growth inhibition of BALB/c mouse cloned 3T3/A31 cells at 10 to 100 ug/mL after 72 hrs by nigrosin assay [AID379092, Type: Literature]
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9
[SID103198631]
IC50 Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay [AID447579, Type: Literature]
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10
[SID103198631]
IC50 64Anticancer activity against human A375 cells after 48 hrs by MTT assay [AID634095, Type: Literature]
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11
[SID103198631]
IC50 87Anticancer activity against human A549 cells after 48 hrs by MTT assay [AID634094, Type: Literature]
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12
[SID103198631]
IC50 91Anticancer activity against human ACHN cells after 48 hrs by MTT assay [AID634098, Type: Literature]
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13
[SID103198631]
IC50 100Inhibitory concentration of compound on nitric oxide (NO) production in lipopolysaccharide activated mouse peritoneal macrophages [AID248765, Type: Literature]
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14
[SID103198631]
IC50 108Anticancer activity against human MCF7 cells after 48 hrs by MTT assay [AID634096, Type: Literature]
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15
[SID103198631]
IC50 114Anticancer activity against human HT-29 cells after 48 hrs by MTT assay [AID634097, Type: Literature]
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16
[SID103198631]
EC50 250Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry [AID590194, Type: Literature]
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17
[SID103198631]
IC50 350Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry [AID590195, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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18
[SID103198631]
IC50 410Inhibition of mushroom tyrosinase after 10 mins by spectrophotometry [AID467606, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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19
[SID103198631]
IC50 671.4Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay [AID379089, Type: Literature]
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20
[SID103198631]
MIC 675Antituberculosis activity against Mycobacterium tuberculosis H37Rv after 7 days by resazurin microtiter assay [AID465565, Type: Literature]
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21
[SID103198631]
IC50 5000Inhibition of alpha-glucosidase activity [AID37266, Type: Literature]
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22
[SID103198631]
 In vitro inhibitory activity against the growth of WISH cell derived from human cervical carcinoma was determined; slight effect [AID216252, Type: Literature]
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23
[SID103198631]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 30 uM after 72 hrs [AID462333, Type: Literature]
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24
[SID103198631]
 Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 30 uM in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay [AID462342, Type: Literature]
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25
[SID103198631]
 Cytotoxicity against human PANC1 cells in nutrient-deprived condition assessed as preferential cell death after 24 hrs by trypan blue dye exclusion method [AID477928, Type: Literature]
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26
[SID103198631]
 Toxicity in erythrocytes assessed as hemolytic activity [AID610073, Type: Literature]
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27
[SID103198631]
 Inhibition of xanthine oxidase- mediated uric acid formation after 5 mins by spectrophotometry [AID670364, Type: Literature]
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28
[SID103198631]
 Inhibition of xanthine oxidase- mediated uric acid formation at 50 ug/mL after 5 mins by spectrophotometry [AID670363, Type: Literature]
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29
[SID103198631]
 Percent inhibition of nitric oxide (NO) production in lipopolysaccharide activated mouse peritoneal macrophages at 100 uM of compound [AID252044, Type: Literature]
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30
[SID103198631]
 Herbicidal activity against velvetleaf assessed as seed germination at 2.5 mM after 4 days relative to control [AID332814, Type: other]
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31
[SID103198631]
 Herbicidal activity against velvetleaf assessed as seed germination at 1 mM after 4 days relative to control [AID332815, Type: other]
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32
[SID103198631]
 Herbicidal activity against velvetleaf assessed as seed germination at 5 mM after 4 days relative to control [AID332816, Type: other]
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33
[SID103198631]
 Percentage inhibition against release of beta-hexosaminidase from RBL-2H3 cells at 100 uM from control [AID166551, Type: Literature]
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34
[SID103198631]
 Gastric cytoprotective activity in male wistar rat [AID174708, Type: Literature]
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35
[SID103198631]
 Antioxidant activity assessed as DPPH radical scavenging activity after 20 mins [AID388743, Type: Literature]
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36
[SID103198631]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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37
[SID103198631]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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38
[SID103198631]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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39
[SID103198631]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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40
[SID103198631]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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41
[SID103198631]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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42
[SID103198631]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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43
[SID103198631]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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44
[SID103198631]
 Growth inhibition of last instar larvae of Tenebrio molitor assessed as successful pupation at 120 ug/larvae, applied topically measured every 24 hrs for 30 days [AID402400, Type: Literature]
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45
[SID103198631]
 Growth inhibition of last instar larvae of Tenebrio molitor assessed as duration of pupal stage at 120 ug/larvae, applied topically measured every 24 hrs for 30 days [AID402401, Type: Literature]
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46
[SID103198631]
 Inhibition of HDAC in human Hela cells nuclear extracts assessed as residual activity at 500 uM by fluorimetric assay [AID447578, Type: Literature]
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47
[SID29217737]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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48
[SID103198631]
 Inhibition of spleen tyrosine kinase in rat RBL-2H3 cells assessed as inhibition of IgE-induced degranulation after 1 hr by beta-hexosaminidase release assay [AID499617, Type: Literature]Tyrosine-protein kinase SYK [gi:3219819]
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49
[SID103198631]
 Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate at 15 uM preincubated for 10 mins before substrate addition measured for every 10 secs for 50 mins by spectrophotometry [AID639826, Type: Literature]Aldose reductase [gi:113596]
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50
[SID103198631]
IC50 Inhibition of cataracted human eye lens aldose reductase [AID388742, Type: Literature]Aldose reductase [gi:113596]
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