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cinnamic acid (CID 444539) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(265)
 
 
Inconclusive(4)
 
 
Unspecified(39)
 
 
Top Targets:
NR LBD ER(16)
 
 
 
NR LBD AR(14)
 
 
NR LBD PPAR(10)
 
 
 
NR LBD GR(8)
 
 
NR LBD TR(8)
 
 
BioAssay Types:
Confirmatory(146)
 
 
 
Literature(115)
 
 
 
 
Summary(39)
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(174)
 
 
 
IC50(19)
 
 
 
 
Ki(1)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 189    Data Row: 318   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103198631]
IC50 0.18Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhage incubated with compound for 10 mins measured after 24 hrs [AID592088, Type: Literature]
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2
[SID103198631]
Ki 4.9Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting [AID594381, Type: Literature]Hydroxycarboxylic acid receptor 2 [gi:74762622]
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3
[SID103198631]
IC50 34.6Antagonist activity at Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus oocytes assessed as inhibition of MES buffer pH 5.5 -induced currents after 30 secs by voltage clamp technique [AID750756, Type: Literature]
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4
[SID103198631]
IC50 43.4Inhibition of N-terminal His-tagged Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) using [3H]acetyl-coA after 25 mins by liquid scintillation counting [AID610072, Type: Literature]3-oxoacyl-[acyl-carrier-protein] synthase 3 [Escherichia coli LF82] [gi:222155839]
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5
[SID103198631]
Inhibition of spleen tyrosine kinase in rat RBL-2H3 cells assessed as inhibition of IgE-induced increase of intracellular calcium level at 50 uM after 30 mins by FLIPR assay [AID499619, Type: Literature]Tyrosine-protein kinase SYK [gi:3219819]
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6
[SID103198631]
Inhibition of spleen tyrosine kinase in rat RBL-2H3 cells assessed as inhibition of IgE-induced increase of ROS level at 50 uM after 30 mins by FLIPR assay [AID499620, Type: Literature]Tyrosine-protein kinase SYK [gi:3219819]
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7
[SID103198631]
Inhibition of spleen tyrosine kinase in rat RBL-2H3 cells assessed as inhibition of IgE-induced upregulation of phospholipase Cgamma1 level at 50 uM after 30 mins by Western blotting [AID499621, Type: Literature]Tyrosine-protein kinase SYK [gi:3219819]
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8
[SID103198631]
Inhibition of spleen tyrosine kinase in rat RBL-2H3 cells assessed as inhibition of IgE-induced upregulation of phospholipase 2 level at 50 uM after 30 mins by Western blotting [AID499622, Type: Literature]Tyrosine-protein kinase SYK [gi:3219819]
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9
[SID103198631]
Growth inhibition of BALB/c mouse cloned 3T3/A31 cells at 10 to 100 ug/mL after 72 hrs by nigrosin assay [AID379092, Type: Literature]
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10
[SID103198631]
IC50 Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay [AID447579, Type: Literature]
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11
[SID103198631]
IC50 64Anticancer activity against human A375 cells after 48 hrs by MTT assay [AID634095, Type: Literature]
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12
[SID103198631]
IC50 87Anticancer activity against human A549 cells after 48 hrs by MTT assay [AID634094, Type: Literature]
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13
[SID103198631]
IC50 91Anticancer activity against human ACHN cells after 48 hrs by MTT assay [AID634098, Type: Literature]
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14
[SID103198631]
IC50 100Inhibition of human amyloid beta (1 to 42) aggregation after 24 hrs by thioflavin-T fluorescence assay [AID688479, Type: Literature]
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15
[SID103198631]
IC50 100Inhibitory concentration of compound on nitric oxide (NO) production in lipopolysaccharide activated mouse peritoneal macrophages [AID248765, Type: Literature]
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16
[SID103198631]
IC50 108Anticancer activity against human MCF7 cells after 48 hrs by MTT assay [AID634096, Type: Literature]
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17
[SID103198631]
IC50 114Anticancer activity against human HT-29 cells after 48 hrs by MTT assay [AID634097, Type: Literature]
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18
[SID103198631]
EC50 250Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry [AID590194, Type: Literature]
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19
[SID103198631]
IC50 350Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry [AID590195, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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20
[SID103198631]
IC50 410Inhibition of mushroom tyrosinase after 10 mins by spectrophotometry [AID467606, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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