CHEMBL240321 (CID 44436936) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Unspecified(2)
 
 
BioAssay Types:
Literature(7)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 7   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103543799]
 Inhibition of IL1-beta induced nitrite production in human articular chondrocytes at 100 ug/ml after 120 hrs [AID302054, Type: Literature]
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2
[SID103543799]
 Inhibition of IL1-beta induced glycosaminoglycans depletion in human articular chondrocytes 10 ug/ml to 100 ug/ml [AID302055, Type: Literature]
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3
[SID103543799]
 Inhibition of IL1-beta induced PGE2 production in human articular chondrocytes at 10 ug/ml to 100 ug/ml [AID302057, Type: Literature]
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4
[SID103543799]
 Inhibition of IL1-beta induced nitrite production in human articular chondrocytes at 50 ug/ml after 120 hrs [AID302053, Type: Literature]
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5
[SID103543799]
 Inhibition of IL1-beta induced nitrite production in human articular chondrocytes at 10 ug/ml after 120 hrs [AID302052, Type: Literature]
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6
[SID103543799]
 Toxicity in human articular chondrocytes assessed as reduction of tetrazolium salt metabolism after 120 hrs by MTT assay [AID302051, Type: Literature]
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7
[SID103543799]
 Inhibition of IL1-beta induced MMP3 secretion in human articular chondrocytes at 100 ug/ml [AID302058, Type: Literature]
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