Bookmark and Share
CHEMBL389521 (CID 44430582) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(1)
 
 
Inactive(1)
 
 
Inconclusive(2)
 
 
Unspecified(11)
 
 
Top Targets:
7tm 4(3)
 
 
 
BioAssay Types:
Literature(15)
 
 
 
 
 
BioActivity Types:
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 15    Data Row: 15   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103532570]
EC50 0.01288Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phosphorylation after 30 mins post dose by Alphascreen Surefire assay [AID541657, Type: Literature]Nociceptin receptor [gi:548426]
View
2
[SID103532570]
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phosphorylation after 30 mins post dose by Alphascreen Surefire assay relative to control [AID541658, Type: Literature]Nociceptin receptor [gi:548426]
View
3
[SID103532570]
Antinociceptive activity in C57BL/6 mouse assessed as maximal increase in paw withdrawal latency administered through intraplanatar route by hot plate test relative to untreated control [AID541670, Type: Literature]
View
4
[SID103532570]
Agonist activity at NOP receptor in Swiss mouse vas deferens assessed as effect on electrically stimulated contractions [AID296541, Type: Literature]Nociceptin receptor [gi:548426]
View
5
[SID103532570]
Tested for maximal effect induced by agonist [AID131274, Type: Literature]
View
6
[SID103532570]
The maximal effect induced by an agonist expressed as percent inhibition of electrically induced twitches. [AID131279, Type: Literature]
View
7
[SID103532570]
Potency (Emax) against electrically evoked contraction (twitch response) in mouse vas deferens [AID138331, Type: Literature]
View
8
[SID103532570]
Compound was tested for agonistic activity against electrically evoked contraction (twitch response) in mouse vas deferens [AID138535, Type: Literature]
View
9
[SID103532570]
Tested for apparent affinity on electrically stimulated mouse vas deferens [AID138538, Type: Literature]
View
10
[SID103532570]
Agonist effect in the electrically stimulated mouse vas deferens. (CL95%) [AID139803, Type: Literature]
View
11
[SID103532570]
Affinity to nociceptin receptors on mouse forebrain membranes by [3H]NC-NH2 displacement. [AID147415, Type: Literature]
View
12
[SID103532570]
Antinociceptive activity in C57BL/6 mouse assessed as increase in paw withdrawal latency administered through intraplanatar route by hot plate test [AID541661, Type: Literature]
View
13
[SID103532570]
Antinociceptive activity in C57BL/6 mouse assessed as increase in paw withdrawal latency administered through intraplanatar route measured 5 mins post dose by hot plate test [AID541667, Type: Literature]
View
14
[SID103532570]
Compound was tested for the antagonistic activity on mouse vas deferens using NC(1-13)NH2 as agonist; ND means not determined [AID138544, Type: Literature]
View
15
[SID103532570]
Antagonist effect in the electrically stimulated mouse vas deferens; Not determined [AID139784, Type: Literature]
View