Bookmark and Share
CHEMBL389521 (CID 44430582) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(49)
 
 
Inactive(2)
 
 
Inconclusive(20)
 
 
Unspecified(62)
 
 
Top Targets:
7TM GPCR Srx(72)
 
 
 
 
BioAssay Types:
Literature(133)
 
 
 
 
 
BioActivity Types:
Ki(21)
 
 
 
EC50(19)
 
 
 
IC50(11)
 
 
Kd(10)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 133    Data Row: 133   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103532570]
Ki 6e-05Binding affinity for human nociceptin (NOP) receptor using [3H]N/OFQ as radioligand transfected into CHO cells [AID147411, Type: Literature]
View
2
[SID103532570]
EC50 8e-05Compound was evaluated for increase in [35S]GTP-gamma-S, binding for human ORL1 receptor carried out in CHO cell membranes; Nd: no data [AID147763, Type: Literature]
View
3
[SID103532570]
Ki 8e-05Displacement of [3H]N/OFQ from human NOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621019, Type: Literature]Nociceptin receptor [gi:730230]
View
4
[SID103532570]
Kd 8.8e-05Binding affinity to recombinant ORL1 receptor Gln205Ala mutant expressed in COS7 cells by saturation binding assay [AID453424, Type: Literature]
View
5
[SID103532570]
EC50 9e-05Agonist activity as stimulation of [35S]-GTP-gamma binding to human Opioid receptor like 1 [AID246515, Type: Literature]Nociceptin receptor [gi:730230]
View
6
[SID103532570]
Kd 9.2e-05Binding affinity to recombinant ORL1 receptor expressed in COS7 cells by saturation binding assay [AID453607, Type: Literature]
View
7
[SID103532570]
Ki 0.0001Binding affinity for opioid receptor like type, human Opioid receptor like 1 expressed in membrane homogenates of COS-1 or CHO cells [AID148869, Type: Literature]
View
8
[SID103532570]
Kd 0.0001Compound was tested for inhibition against binding of radioligand [leucyl-3H]-OFQ to membrane of human embryonic kidney 293 cells overexpressing rat Opioid receptor like 1 [AID148877, Type: Literature]
View
9
[SID103532570]
Ki 0.00013Displacement of [125I]Tyr14-nociceptin from human NOP receptor expressed in HEK293 cells [AID315424, Type: Literature]Nociceptin receptor [gi:730230]
View
10
[SID103532570]
Ki 0.00018Inhibition of [3H]nociceptin binding to human Opioid receptor like 1 [AID239061, Type: Literature]Nociceptin receptor [gi:730230]
View
11
[SID103532570]
IC50 0.00021Displacement of [3H]nociceptin from recombinant ORL1 receptor expressed in COS7 cells by competitive receptor binding assay [AID453420, Type: Literature]
View
12
[SID103532570]
IC50 0.00022Displacement of [3H]nociceptin from recombinant ORL1 receptor Trp208Ala mutant expressed in COS7 cells by competitive receptor binding assay [AID453416, Type: Literature]
View
13
[SID103532570]
IC50 0.00022Displacement of [3H]nociceptin from recombinant ORL1 receptor Gln205Ala mutant expressed in COS7 cells by competitive receptor binding assay [AID453419, Type: Literature]
View
14
[SID103532570]
IC50 0.00029Binding affinity to ORL1 receptor (unknown origin) by radioligand displacement assay [AID752226, Type: Literature]Nociceptin receptor [gi:730230]
View
15
[SID103532570]
Ki 0.0003Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells [AID148870, Type: Literature]Nociceptin receptor [gi:730230]
View
16
[SID103532570]
EC50 0.000389Antagonist activity at human recombinant NOP receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of N/OFQ-induced intracellular calcium mobilization [AID375525, Type: Literature]Nociceptin receptor [gi:730230]
View
17
[SID103532570]
Ki 0.00039Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells [AID367833, Type: Literature]Nociceptin receptor [gi:730230]
View
18
[SID103532570]
EC50 0.00045Affinity for human Opioid receptor like 1 (ORL-1) expressed in HEK293 cells [AID148859, Type: Literature]Nociceptin receptor [gi:730230]
View
19
[SID103532570]
Kd 0.00049Binding affinity to recombinant ORL1 receptor Trp208Ala mutant expressed in COS7 cells by saturation binding assay [AID453421, Type: Literature]
View
20
[SID103532570]
IC50 0.00054Displacement of [3H]nociceptin from recombinant ORL1 receptor Asp206Ala mutant expressed in COS7 cells by competitive receptor binding assay [AID453418, Type: Literature]
View