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BioActivity Data for Compound Acarbose (CID 444254)

BioActivity Outcomes:
Active(76)
 
 
Inactive(125)
 
 
Inconclusive(9)
 
 
Unspecified(1526)
 
 
Top Targets:
GH31 MGAM SI..(43)
 
 
 
7tm 4(32)
 
 
 
p450(10)
 
 
 
NR LBD ER(9)
 
 
 
 
NR LBD AR(8)
 
 
 
BioAssay Types:
Literature(214)
 
 
 
 
 
Confirmatory(214)
 
 
 
 
 
Summary(29)
 
 
 
 
Screening(10)
 
 
BioAssay Categories:
In vitro(137)
 
 
 
In vivo(1243)
 
 
Biochemical(270)
 
 
 
 
 
Toxicity(1260)
 
 
 
ADME(40)
 
 
 
Cell-based(99)
 
 
 
 
BioActivity Types:
IC50(205)
 
 
 
 
 
Potency(101)
 
 
 
 
AC50(12)
 
 
Ki(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1733    Data Row: 1736   Total Pages: 87   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID46391424]
Ki 1e-06Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Refined Structure For The Complex Of Acarbose With Glucoamylase From Aspergillus Awamori Var. X100 To 2.4 Angstroms Resolution [gi:157829865]
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2
[SID46391424]
Ki 1e-06Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Refined Structure For The Complex Of Acarbose With Glucoamylase From Aspergillus Awamori Var. X100 To 2.4 Angstroms Resolution [gi:157829865]
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3
[SID103585278]
Ki 0.009Inhibition of mouse his-tagged ctMGAM-N2 expressed in Sf9 cells assessed as amount of glucose produced using maltose as a substrate after 45 mins by glucose oxidase assay [AID620760, Type: Literature]
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4
[SID103585278]
Ki 0.028Inhibition of mouse his-tagged ctMGAM-N20 expressed in Sf9 cells assessed as amount of glucose produced using maltose as a substrate after 45 mins by glucose oxidase assay [AID620761, Type: Literature]
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5
[SID103585278]
IC50 0.033Inhibition of Bacillus stearothermophilus alpha-glucosidase type IV [AID427710, Type: Literature]
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6
[SID103585278]
IC50 0.034Inhibition of Bacillus stearothermophilus alpha-glucosidase type 4 [AID692014, Type: Literature]
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7
[SID103585278]
IC50 0.049Inhibition of Bacillus stearothermophilus alpha glucosidase-4 [AID497106, Type: Literature]
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8
[SID103585278]
IC50 0.1Inhibition of Bacillus stearothermophilus alpha-glucosidase [AID391607, Type: Literature]
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9
[SID103585278]
IC50 0.1Inhibition of Saccharomyces cerevisiae alpha-glucosidase [AID391608, Type: Literature]
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10
[SID103585278]
IC50 0.16Inhibition of Wistar rat small intestine maltase after 30 mins [AID550393, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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11
[SID103585278]
IC50 0.18Inhibition of rat intestinal maltase using moltose as substrate [AID711104, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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12
[SID103585278]
Ki 0.246Inhibition of mouse his-tagged ctSI expressed in Sf9 cells assessed as amount of glucose produced using maltose as a substrate after 45 mins by glucose oxidase assay [AID620763, Type: Literature]
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13
[SID103585278]
Ki 0.34Competitive inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as production of chromogenic p-Nitrphenol measured after 3 mins by HPLC and Michaelis-Menten equation [AID590733, Type: Literature]Exo-alpha-1,4-glucosidase [gi:75499522]
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14
[SID103585278]
IC50 0.35Inhibition of rat intestinal brush border membrane maltase [AID342793, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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15
[SID103585278]
IC50 0.4Inhibition of rat intestinal sucrase using sucrose as substrate assessed as D-glucose release from substrate preincubated for 15 mins measured after 60 mins [AID763817, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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16
[SID103585278]
IC50 0.54Inhibition of rat intestinal alpha-glucosidase using sucrose as substrate assessed as glucose formation incubated for 10 mins prior to substrate addition measured after 30 mins by glucose oxidase method [AID778972, Type: Literature]
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17
[SID103585278]
IC50 0.56Inhibition of rat intestinal brush border membrane sucrase [AID342797, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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18
[SID103585278]
Ki 0.99Inhibition of maltase in rat small intestine using maltose as substrate by Lineweaver-Burk plot based secondary replot analysis [AID1120996, Type: confirmatory]
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19
[SID103585278]
IC50 1.5Inhibition of type 2 alpha-glucosidase in rat small intestine using maltose as substrate after 10 mins by microplate reader analysis [AID1120990, Type: confirmatory]
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20
[SID103585278]
IC50 1.5Inhibition of rat small intestinal sucrase after 30 mins by glucose-oxidase method [AID594100, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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