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BioActivity Data for Compound CHEMBL382277 (CID 44405122)

BioActivity Outcomes:
Active(1)
 
 
Inconclusive(2)
 
 
Unspecified(1)
 
 
Top Targets:
SIRT1(4)
 
 
 
 
BioAssay Types:
Confirmatory(3)
 
 
 
Literature(1)
 
 
BioAssay Categories:
Biochemical(3)
 
 
 
BioActivity Types:
IC50(4)
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 4    Data Row: 4   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103472827]
IC50 0.76Inhibition of human SIRT1 using peptide substrate assessed as deacetylase activity [AID1117484, Type: confirmatory]NAD-dependent protein deacetylase sirtuin-1 [gi:38258633]
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2
[SID103472827]
IC50 100Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assay [AID256743, Type: Literature]NAD-dependent protein deacetylase sirtuin-1 [gi:38258633]
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3
[SID103472827]
IC50 Inhibition of GST-tagged SIRT2 (unknown origin) by HPLC assay [AID1117495, Type: confirmatory]NAD-dependent protein deacetylase sirtuin-2 [gi:38258608]
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4
[SID103472827]
IC50 Inhibition of GST-tagged SIRT3 (unknown origin) by HPLC assay [AID1117496, Type: confirmatory]NAD-dependent protein deacetylase sirtuin-3, mitochondrial [gi:38258651]
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