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tibolone (CID 444008) - Compound BioActivity Data
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BioActivity Outcomes:
Active(21)
 
 
Inactive(213)
 
 
Inconclusive(15)
 
 
Unspecified(127)
 
 
Top Targets:
7TM GPCR Srx(18)
 
 
 
7TM GPCR Srsx(17)
 
 
 
p450(10)
 
 
 
 
NR LBD ER(9)
 
 
 
 
 
NR LBD PPAR(8)
 
 
 
BioAssay Types:
Confirmatory(195)
 
 
 
 
 
Screening(130)
 
 
Summary(24)
 
 
 
 
BioActivity Types:
IC50(125)
 
 
 
 
Potency(85)
 
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 366    Data Row: 376   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144205803]
Potency-Replicate_1 0.0034qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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2
[SID144205803]
Ratio Potency (uM) 0.00379019qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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3
[SID144205803]
Potency-Replicate_1 0.0038qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID144205803]
Potency-Replicate_1 0.0053qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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5
[SID144205803]
Potency-Replicate_1 0.0134qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID144205803]
Ratio Potency (uM) 0.0248257qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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7
[SID144205803]
Potency-Replicate_1 0.0425qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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8
[SID144205803]
Ratio Potency (uM) 0.0648625qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
9
[SID160692461]
IC50 0.0907DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: confirmatory]Sodium-dependent serotonin transporter [gi:400630]
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10
[SID160692461]
IC50 0.113DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: confirmatory]Androgen receptor [gi:113832]
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11
[SID160692461]
IC50 0.2197DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: confirmatory]Progesterone receptor [gi:75071465]
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12
[SID160692461]
IC50 0.4333DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: confirmatory]Estrogen receptor [gi:544257]
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13
[SID160692461]
IC50 3DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625247, Type: confirmatory]Cytochrome P450 2C19 [gi:60416369]
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14
[SID144205803]
Potency-Replicate_1 9.5205qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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15
[SID144205803]
Potency-Replicate_1 10.5909qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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16
[SID144205803]
Potency-Replicate_1 21.1317qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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17
[SID170465874]
Potency-Replicate_1 23.7083qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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18
[SID144205803]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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19
[SID144205803]
Potency-Replicate_1 29.8493qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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20
[SID48416626]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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