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Bupropion (CID 444) - Compound BioActivity Data
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BioActivity Outcomes:
Active(54)
 
 
Inactive(213)
 
 
Inconclusive(5)
 
 
Unspecified(471)
 
 
Top Targets:
Neur chan LBD(27)
 
 
 
7TM GPCR Srx(22)
 
 
 
 
7TM GPCR Srsx(16)
 
 
 
SLC6sbd DAT1(10)
 
 
 
 
p450(10)
 
 
 
BioAssay Types:
Literature(263)
 
 
 
 
 
Confirmatory(200)
 
 
 
 
 
Screening(115)
 
 
BioActivity Types:
IC50(173)
 
 
 
 
 
Potency(71)
 
 
 
Ki(4)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 712    Data Row: 743   Total Pages: 38   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103234592]
IC50 0.0018Antagonist activity at alpha3beta4 nAChR receptor in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting [AID459714, Type: Literature]
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2
[SID103234592]
IC50 0.0079Antagonist activity at alpha-1-beta-1-gamma-delta nAChR receptor expressed in human TE671/RD cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting [AID459717, Type: Literature]
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3
[SID103234592]
IC50 0.012Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting [AID459715, Type: Literature]
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4
[SID103234592]
IC50 0.015Antagonist activity at human alpha4beta4 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting [AID459716, Type: Literature]
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5
[SID103234592]
Ki 0.441Displacement of [3H]WIN-35428 from human dopamine transporter expressed in mouse N2A cells by scintillation counting [AID420091, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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6
[SID103234592]
IC50 0.443Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cells [AID444522, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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7
[SID103234592]
IC50 0.658Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells [AID459711, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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8
[SID103234592]
IC50 0.658Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of [3H]DA reuptake after 10 mins by scintillation counting [AID610457, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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9
[SID103234592]
IC50 0.66Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells after 90 mins by scintillation counting [AID491169, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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10
[SID103234592]
Ki 0.871Displacement of [125I]RTI55 from cloned human DAT expressed in HEK293 cells [AID444517, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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11
[SID103234592]
IC50 0.9In vitro inhibition of dopamine (DA) uptake in synaptosomal preparation of rat brain [AID195890, Type: Literature]
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12
[SID103234592]
IC50 0.945Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells [AID444520, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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13
[SID103234592]
IC50 1Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta2 [AID241632, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:113105]
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14
[SID103234592]
IC50 1Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta2 [AID241632, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:254763435]
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15
[SID103234592]
IC50 1.0338DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: confirmatory]Sodium-dependent dopamine transporter [gi:266667]
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16
[SID103234592]
IC50 1.45Inhibition of Norepinephrine (NA) reuptake using cloned human transporter was determined [AID147723, Type: Literature]
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17
[SID103234592]
IC50 1.567Inhibition of [3H]dopamine uptake at human dopamine transporter expressed in mouse N2A cells by scintillation counting [AID420092, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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18
[SID103234592]
IC50 1.8Antagonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting [AID491177, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:2506129]
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19
[SID103234592]
IC50 1.8Antagonist activity against human ganglionic alpha3beta4alpha5beta2 nAChR in SHSY5Y cells assessed as inhibition of carbamylcholine induced 86Rb+ efflux [AID610456, Type: Literature]
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20
[SID103234592]
IC50 1.8Antagonist activity at alpha3beta4 nicotinic receptor in human SH-SY5Y cells assessed as inhibition varbamylcholine-induced radiolabeled Rb+ influx at by liquid scintillation counting [AID491177, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:254763435]
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